IT1180210B - 16-fluoro-16,17-dideidro prostanoidi e procedimento per la loro preparazione - Google Patents
16-fluoro-16,17-dideidro prostanoidi e procedimento per la loro preparazioneInfo
- Publication number
- IT1180210B IT1180210B IT22159/84A IT2215984A IT1180210B IT 1180210 B IT1180210 B IT 1180210B IT 22159/84 A IT22159/84 A IT 22159/84A IT 2215984 A IT2215984 A IT 2215984A IT 1180210 B IT1180210 B IT 1180210B
- Authority
- IT
- Italy
- Prior art keywords
- prostanoid
- didehydro
- fluoro
- procedure
- preparation
- Prior art date
Links
- 229940127293 prostanoid Drugs 0.000 title 1
- 150000003814 prostanoids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838324004A GB8324004D0 (en) | 1983-09-07 | 1983-09-07 | 16-fluoro-16 17-didehydro prostanoids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8422159A0 IT8422159A0 (it) | 1984-08-01 |
| IT1180210B true IT1180210B (it) | 1987-09-23 |
Family
ID=10548451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT22159/84A IT1180210B (it) | 1983-09-07 | 1984-08-01 | 16-fluoro-16,17-dideidro prostanoidi e procedimento per la loro preparazione |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4626597A (it) |
| JP (1) | JPS6072859A (it) |
| KR (1) | KR850002830A (it) |
| AU (1) | AU562725B2 (it) |
| BE (1) | BE900414A (it) |
| CH (1) | CH662114A5 (it) |
| CS (1) | CS259869B2 (it) |
| DE (1) | DE3430626A1 (it) |
| DK (1) | DK406484A (it) |
| ES (2) | ES8607022A1 (it) |
| FI (1) | FI843285A (it) |
| FR (1) | FR2551436B1 (it) |
| GB (2) | GB8324004D0 (it) |
| GR (1) | GR80204B (it) |
| HU (1) | HU192430B (it) |
| IL (1) | IL72749A (it) |
| IT (1) | IT1180210B (it) |
| NL (1) | NL8402666A (it) |
| NO (1) | NO843355L (it) |
| NZ (1) | NZ209294A (it) |
| PT (1) | PT79113B (it) |
| SE (1) | SE8404334L (it) |
| SU (1) | SU1442070A3 (it) |
| ZA (1) | ZA846580B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8625326D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Medicaments |
| ES2051862T3 (es) * | 1987-10-02 | 1994-07-01 | Ueno Seiyaku Oyo Kenkyujo Kk | Un metodo para producir un medicamento que tiene un efecto catartico. |
| US5317032A (en) * | 1987-10-02 | 1994-05-31 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Prostaglandin cathartic |
| AU616564B2 (en) * | 1988-09-29 | 1991-10-31 | Sumitomo Chemical Company, Limited | Novel pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof |
| US5099644A (en) * | 1990-04-04 | 1992-03-31 | General Electric Company | Lean staged combustion assembly |
| CA2269855A1 (en) * | 1996-11-12 | 1998-05-22 | Alcon Laboratories, Inc. | 15-fluoro prostaglandins as ocular hypotensives |
| US6680339B2 (en) | 1996-11-12 | 2004-01-20 | Alcon Manufacturing, Ltd. | 15-fluoro prostaglandins as ocular hypotensives |
| SI1480949T1 (sl) * | 2002-03-01 | 2015-09-30 | Allergan, Inc. | Priprava prostamidov |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987087A (en) * | 1971-07-29 | 1976-10-19 | The Upjohn Company | Phenyl-substituted prostaglandin-f type analogs |
| GB1396206A (en) * | 1972-04-27 | 1975-06-04 | Upjohn Co | Prostaglandins and the preparation thereof |
| ZA744581B (en) * | 1973-07-20 | 1975-07-30 | Upjohn Co | Prostoglandin analogs |
| US4059576A (en) * | 1973-08-06 | 1977-11-22 | Hoffmann-La Roche, Inc. | 11-Substituted prostaglandins |
| GB1484591A (en) * | 1974-04-11 | 1977-09-01 | Ono Pharmaceutical Co | Prostaglandin compositions |
| AU501803B2 (en) * | 1975-03-21 | 1979-06-28 | Farmitalia Carlo Erba S.P.A. | Fluoro-prostaglandins |
| US4268522A (en) * | 1976-06-14 | 1981-05-19 | Pfizer Inc. | 13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof |
| US4283417A (en) * | 1976-06-14 | 1981-08-11 | Pfizer Inc. | Bronchodialation with 13,14-dihydro-15-alkenyl prostaglandins |
-
1983
- 1983-09-07 GB GB838324004A patent/GB8324004D0/en active Pending
-
1984
- 1984-08-01 IT IT22159/84A patent/IT1180210B/it active
- 1984-08-20 GB GB08421124A patent/GB2146325B/en not_active Expired
- 1984-08-20 FI FI843285A patent/FI843285A/fi not_active Application Discontinuation
- 1984-08-20 DE DE19843430626 patent/DE3430626A1/de not_active Withdrawn
- 1984-08-21 AU AU32231/84A patent/AU562725B2/en not_active Ceased
- 1984-08-21 NZ NZ209294A patent/NZ209294A/en unknown
- 1984-08-21 FR FR8413013A patent/FR2551436B1/fr not_active Expired
- 1984-08-22 US US06/643,014 patent/US4626597A/en not_active Expired - Fee Related
- 1984-08-22 CS CS846360A patent/CS259869B2/cs unknown
- 1984-08-22 NO NO843355A patent/NO843355L/no unknown
- 1984-08-22 CH CH4020/84A patent/CH662114A5/de not_active IP Right Cessation
- 1984-08-22 PT PT79113A patent/PT79113B/pt unknown
- 1984-08-22 IL IL72749A patent/IL72749A/xx unknown
- 1984-08-23 ZA ZA846580A patent/ZA846580B/xx unknown
- 1984-08-23 BE BE0/213533A patent/BE900414A/fr not_active IP Right Cessation
- 1984-08-24 KR KR1019840005144A patent/KR850002830A/ko not_active Application Discontinuation
- 1984-08-24 DK DK406484A patent/DK406484A/da not_active Application Discontinuation
- 1984-08-24 GR GR80204A patent/GR80204B/el unknown
- 1984-08-28 JP JP59177631A patent/JPS6072859A/ja active Pending
- 1984-08-30 SE SE8404334A patent/SE8404334L/xx not_active Application Discontinuation
- 1984-08-30 ES ES535551A patent/ES8607022A1/es not_active Expired
- 1984-08-31 NL NL8402666A patent/NL8402666A/nl not_active Application Discontinuation
- 1984-08-31 HU HU843291A patent/HU192430B/hu unknown
-
1985
- 1985-05-31 ES ES543776A patent/ES8604135A1/es not_active Expired
- 1985-10-10 SU SU853961258A patent/SU1442070A3/ru active
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