IS2274B - Aðferð til að búa til kamptóþesín afleiður - Google Patents
Aðferð til að búa til kamptóþesín afleiðurInfo
- Publication number
- IS2274B IS2274B IS4730A IS4730A IS2274B IS 2274 B IS2274 B IS 2274B IS 4730 A IS4730 A IS 4730A IS 4730 A IS4730 A IS 4730A IS 2274 B IS2274 B IS 2274B
- Authority
- IS
- Iceland
- Prior art keywords
- pct
- date
- camptothecin derivatives
- sec
- formula
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US613895P | 1995-11-02 | 1995-11-02 | |
| PCT/US1996/017574 WO1997016454A1 (en) | 1995-11-02 | 1996-11-01 | Method for preparing camptothecin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IS4730A IS4730A (is) | 1998-04-29 |
| IS2274B true IS2274B (is) | 2007-09-15 |
Family
ID=21719492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS4730A IS2274B (is) | 1995-11-02 | 1998-04-29 | Aðferð til að búa til kamptóþesín afleiður |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6143891A (is) |
| EP (1) | EP0876373B1 (is) |
| JP (1) | JP3499246B2 (is) |
| AT (1) | ATE301659T1 (is) |
| AU (1) | AU717315B2 (is) |
| CA (1) | CA2236420A1 (is) |
| CZ (1) | CZ133898A3 (is) |
| DE (1) | DE69635057T2 (is) |
| EA (1) | EA001400B1 (is) |
| ES (1) | ES2247606T3 (is) |
| HU (1) | HUP9802407A3 (is) |
| IL (1) | IL124287A (is) |
| IS (1) | IS2274B (is) |
| NO (1) | NO324308B1 (is) |
| NZ (1) | NZ322318A (is) |
| PL (1) | PL186540B1 (is) |
| WO (1) | WO1997016454A1 (is) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
| US6716982B2 (en) | 1995-11-02 | 2004-04-06 | Osi Pharmaceuticals, Inc. | Method for preparing camptothecin derivatives |
| US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| TWI245768B (en) | 2001-02-21 | 2005-12-21 | Yakult Honsha Kk | Process for synthesizing camptothecin related compound(s) |
| AU2003207369A1 (en) * | 2002-02-18 | 2003-09-04 | Dr. Reddy's Laboratories Limited | A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride |
| US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| KR20070008710A (ko) | 2004-04-27 | 2007-01-17 | 웰스테트 바이올로직스 코포레이션 | 바이러스 및 캄토테신을 이용한 암치료 방법 |
| JP5190958B2 (ja) | 2005-07-14 | 2013-04-24 | ウェルスタット バイオロジクス コーポレイション | ウイルス、フルオロピリミジンおよびカンプトテシンを使用した癌の処置 |
| CN103288842B (zh) * | 2012-02-24 | 2016-01-13 | 中国人民解放军第二军医大学 | 氟取代e环喜树碱类似物及其作为药物的用途 |
| KR20180058759A (ko) | 2015-09-25 | 2018-06-01 | 제트와이 테라퓨틱스 인코포레이티드 | 폴리사카라이드-비타민 접합체를 포함하는 미립자를 기재로 하는 약물 제제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ240406A (en) * | 1990-10-31 | 1994-05-26 | Smithkline Beecham Corp | Substituted indolizino [1,2-b]quinolin-9(11h)-one derivatives, pharmaceutical formulations and use as antiviral agents |
| AU3611093A (en) * | 1992-02-21 | 1993-09-13 | Smithkline Beecham Corporation | Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones |
-
1996
- 1996-11-01 CZ CZ981338A patent/CZ133898A3/cs unknown
- 1996-11-01 CA CA002236420A patent/CA2236420A1/en not_active Abandoned
- 1996-11-01 JP JP51758897A patent/JP3499246B2/ja not_active Expired - Fee Related
- 1996-11-01 AU AU76038/96A patent/AU717315B2/en not_active Ceased
- 1996-11-01 DE DE69635057T patent/DE69635057T2/de not_active Expired - Fee Related
- 1996-11-01 NZ NZ322318A patent/NZ322318A/xx unknown
- 1996-11-01 ES ES96938728T patent/ES2247606T3/es not_active Expired - Lifetime
- 1996-11-01 AT AT96938728T patent/ATE301659T1/de not_active IP Right Cessation
- 1996-11-01 WO PCT/US1996/017574 patent/WO1997016454A1/en not_active Application Discontinuation
- 1996-11-01 PL PL96326869A patent/PL186540B1/pl not_active IP Right Cessation
- 1996-11-01 EA EA199800354A patent/EA001400B1/ru not_active IP Right Cessation
- 1996-11-01 HU HU9802407A patent/HUP9802407A3/hu unknown
- 1996-11-01 US US09/068,185 patent/US6143891A/en not_active Expired - Fee Related
- 1996-11-01 EP EP96938728A patent/EP0876373B1/en not_active Expired - Lifetime
- 1996-11-01 IL IL12428796A patent/IL124287A/en not_active IP Right Cessation
-
1998
- 1998-04-29 IS IS4730A patent/IS2274B/is unknown
- 1998-04-30 NO NO19981970A patent/NO324308B1/no unknown
-
2000
- 2000-08-15 US US09/638,945 patent/US6284891B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69635057T2 (de) | 2006-06-01 |
| PL326869A1 (en) | 1998-10-26 |
| ES2247606T3 (es) | 2006-03-01 |
| NZ322318A (en) | 2000-01-28 |
| NO324308B1 (no) | 2007-09-24 |
| IS4730A (is) | 1998-04-29 |
| WO1997016454A1 (en) | 1997-05-09 |
| JPH11515028A (ja) | 1999-12-21 |
| NO981970D0 (no) | 1998-04-30 |
| NO981970L (no) | 1998-06-30 |
| JP3499246B2 (ja) | 2004-02-23 |
| EA001400B1 (ru) | 2001-02-26 |
| EP0876373A1 (en) | 1998-11-11 |
| IL124287A (en) | 2004-06-01 |
| EP0876373B1 (en) | 2005-08-10 |
| US6143891A (en) | 2000-11-07 |
| EA199800354A1 (ru) | 1999-02-25 |
| PL186540B1 (pl) | 2004-01-30 |
| US6284891B1 (en) | 2001-09-04 |
| HUP9802407A3 (en) | 2000-01-28 |
| HUP9802407A1 (hu) | 1999-04-28 |
| AU7603896A (en) | 1997-05-22 |
| CA2236420A1 (en) | 1997-05-09 |
| ATE301659T1 (de) | 2005-08-15 |
| CZ133898A3 (cs) | 1998-08-12 |
| DE69635057D1 (de) | 2005-09-15 |
| AU717315B2 (en) | 2000-03-23 |
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