IN2015DN02696A - - Google Patents

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Publication number
IN2015DN02696A
IN2015DN02696A IN2696DEN2015A IN2015DN02696A IN 2015DN02696 A IN2015DN02696 A IN 2015DN02696A IN 2696DEN2015 A IN2696DEN2015 A IN 2696DEN2015A IN 2015DN02696 A IN2015DN02696 A IN 2015DN02696A
Authority
IN
India
Prior art keywords
matrix
perfusion path
void
fluidic connection
microfluidic device
Prior art date
Application number
Other languages
English (en)
Inventor
Thomas; Neumann
Anna A ; Tourovskaia
Mark E ; Fauver
Greg; Kramer
Elizabeth; Asp
Henning; Mann
Original Assignee
Nortis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nortis Inc filed Critical Nortis Inc
Publication of IN2015DN02696A publication Critical patent/IN2015DN02696A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/0231—Chemically defined matrices, e.g. alginate gels, for immobilising, holding or storing cells, tissue or organs for preservation purposes; Chemically altering or fixing cells, tissue or organs, e.g. by cross-linking, for preservation purposes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
IN2696DEN2015 2012-09-29 2013-09-27 IN2015DN02696A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261707907P 2012-09-29 2012-09-29
US201261721002P 2012-10-31 2012-10-31
PCT/US2013/062307 WO2014052835A1 (en) 2012-09-29 2013-09-27 Microfluidic system for reproducing functional units of tissues and organs in vitro

Publications (1)

Publication Number Publication Date
IN2015DN02696A true IN2015DN02696A (zh) 2015-09-04

Family

ID=50389014

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2696DEN2015 IN2015DN02696A (zh) 2012-09-29 2013-09-27

Country Status (9)

Country Link
US (2) US20150240194A1 (zh)
EP (1) EP2900801A4 (zh)
JP (1) JP6396909B2 (zh)
CN (1) CN104837982B (zh)
AU (1) AU2013323222A1 (zh)
CA (1) CA2886247C (zh)
HK (1) HK1213287A1 (zh)
IN (1) IN2015DN02696A (zh)
WO (1) WO2014052835A1 (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101741815B1 (ko) 2014-05-23 2017-06-16 서강대학교산학협력단 세포 공동-배양을 위한 하이드로젤 기반 미세유체칩
EP3161052A4 (en) 2014-06-26 2018-03-21 Northeastern University Microfluidic device and method for analysis of tumor cell microenvironments
KR102393885B1 (ko) 2014-06-27 2022-05-02 앤지오크린 바이오사이언스 인코포레이티드 아데노바이러스 e4orf1을 발현하는 신경 세포 및 그 제조 방법과 용도
WO2016064757A1 (en) * 2014-10-19 2016-04-28 Nortis, Inc. Modular microfluidic system for perfused cell culture
US20170355940A1 (en) * 2014-11-19 2017-12-14 Nortis, Inc. Method for vascularizing in-vitro generated or ex-vivo tissue fragments in a microfluidic device
WO2017003546A2 (en) * 2015-04-24 2017-01-05 President And Fellows Of Harvard College Devices for simulating a function of a tissue and methods of use and manufacturing thereof
GB2588276B (en) * 2015-04-24 2021-07-14 Harvard College Devices for simulating a function of a tissue and methods of use and manufacturing thereof
CN104849439B (zh) * 2015-04-30 2017-01-18 四川农业大学 一种高效检测纳米颗粒肾毒性的方法
KR20180057618A (ko) 2015-08-14 2018-05-30 더 제너럴 하스피탈 코포레이션 살아있는 조직에서 소통을 제공하는 생체 모방 구조를 사용하기 위한 시스템 및 방법
WO2018026784A1 (en) * 2016-08-01 2018-02-08 University Of Georgia Research Foundation, Inc. In situ cell delivery using reconstituted photopolymerized chondroitin sulfate glycosaminoglycan hydrogel matrices
EP3652303A4 (en) * 2017-07-14 2021-03-03 The Governing Council of the University of Toronto MICROFLUIDIC PLATFORM FOR RAPID PRODUCTION OF ORGANOIDS / SPHEROIDS FOR COMPOUND SCREENING
WO2019060680A1 (en) 2017-09-22 2019-03-28 The Regents Of The University Of Colorado, A Body Corporate MICROPHYSIOLOGICAL ORGAN-ON-CHIP SYSTEM
WO2019079725A1 (en) 2017-10-19 2019-04-25 Georgia Tech Research Corporation MESOFLUIDIC DEVICE FOR CULTIVATION OF CELLULAR AGGREGATES
KR102124420B1 (ko) * 2017-11-02 2020-06-18 한국과학기술연구원 선 스트레인의 조합 및 물성에 따른 구조체 내 미세섬유 정렬 제어 방법
CA3086725C (en) * 2017-12-22 2024-01-09 Tissuse Gmbh Novel multi-organ-chips establishing differentiation of ipsc-derived cells into organ equivalents
CA3086392A1 (en) * 2017-12-22 2019-06-27 Tissuse Gmbh Novel microfluidic devices implementing blood and urine circuit for emulating homeostatic microphysiological system
US11679546B2 (en) 2018-02-09 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate Bioprinter and methods of manufacturing an organomimetic device
EP3797151A4 (en) * 2018-05-22 2022-04-20 Morphocell Technologies Inc. PERFUSION BIOREACTOR, PERFUSION DEVICE, ARTIFICIAL LIVER SYSTEM AND RELATED PROCEDURES
US11480560B2 (en) 2018-06-11 2022-10-25 The Regents Of The University Of Colorado, A Body Corporate Delivery of aerosolized respiratory pathogens
GB201901273D0 (en) * 2019-01-30 2019-03-20 Stemnovate Ltd Method and apparatus for real time monitoring of cell and tissue culture
CN110108622B (zh) * 2019-06-17 2024-02-02 辽宁中医药大学 一种离体微血管内皮屏障功能检测方法与设备
CN110295111A (zh) * 2019-07-15 2019-10-01 清华大学深圳研究生院 一种仿生血管网络肿瘤细胞外渗迁移的装置
US20220331502A1 (en) * 2020-06-26 2022-10-20 Ykrita Lifesciences Private Limited Bioengineered Artificial Lateral Liver (BALL) or Bioengineered Artificial Ectopic Liver (BAEL)
US20220062895A1 (en) * 2020-08-27 2022-03-03 Wisconsin Alumni Research Foundation Microfluidic Device And Method Of Assaying For Immune Cell Exhaustion Using Same
KR20230146599A (ko) * 2021-02-19 2023-10-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 조직을 세포 현탁액으로 소화하기 위한 미세유체 디바이스
CN112958172B (zh) * 2021-02-24 2021-12-28 北京航空航天大学 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片
CN114350515A (zh) * 2022-01-11 2022-04-15 中国药科大学 用于内皮细胞三维培养灌注的器官芯片及其应用
CN114854585B (zh) * 2022-05-11 2022-09-30 中国中医科学院中药研究所 一种用于中药肝毒性评价的基于微流控体系的精密肝切片培养模型

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US6632666B2 (en) * 2000-01-14 2003-10-14 Biolife Solutions, Inc. Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media
EP1392814B1 (en) * 2001-04-25 2007-06-13 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
EP1636332A4 (en) * 2003-05-06 2007-08-29 Bellbrook Labs Llc THREE-DIMENSIONAL CELL CULTURES IN A SMALL-SCALE FLUID HANDLING SYSTEM
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20090263849A1 (en) * 2006-04-21 2009-10-22 Drexel University Bioprinting Three-Dimensional Structure Onto Microscale Tissue Analog Devices for Pharmacokinetic Study and Other Uses
US8343740B2 (en) * 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
CN101372662B (zh) * 2008-03-18 2011-06-08 北京航空航天大学 一种具有培养腔旋转和血管牵张功能的血管组织工程反应器
US11124757B2 (en) * 2009-07-14 2021-09-21 Kikkoman Corporation Microorganism culture sheet and manufacturing method therefor
US9810685B2 (en) * 2010-10-05 2017-11-07 The Regents Of The University Of California High-throughput platform comprising microtissues perfused with living microvessels
US20150087004A1 (en) * 2012-02-02 2015-03-26 The Trustees Of The University Of Pennsylvania Microfabricated 3D Cell Culture System

Also Published As

Publication number Publication date
US20190062684A1 (en) 2019-02-28
JP6396909B2 (ja) 2018-09-26
EP2900801A4 (en) 2016-06-22
CN104837982B (zh) 2017-11-21
HK1213287A1 (zh) 2016-06-30
US20150240194A1 (en) 2015-08-27
EP2900801A1 (en) 2015-08-05
CA2886247C (en) 2023-01-03
CN104837982A (zh) 2015-08-12
AU2013323222A1 (en) 2015-04-09
CA2886247A1 (en) 2014-04-03
JP2015533083A (ja) 2015-11-19
WO2014052835A1 (en) 2014-04-03

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