IN2015DN01700A - - Google Patents
Info
- Publication number
- IN2015DN01700A IN2015DN01700A IN1700DEN2015A IN2015DN01700A IN 2015DN01700 A IN2015DN01700 A IN 2015DN01700A IN 1700DEN2015 A IN1700DEN2015 A IN 1700DEN2015A IN 2015DN01700 A IN2015DN01700 A IN 2015DN01700A
- Authority
- IN
- India
- Prior art keywords
- human
- dominancy
- sera
- feasibility
- supports
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/208—Pseudochromosomes, minichrosomosomes of mammalian origin, e.g. minichromosome
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261679288P | 2012-08-03 | 2012-08-03 | |
| PCT/US2013/053618 WO2014022853A1 (en) | 2012-08-03 | 2013-08-05 | Complex chromosome engineering for production of human antibodies in transgenic animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01700A true IN2015DN01700A (enrdf_load_stackoverflow) | 2015-05-22 |
Family
ID=48949296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1700DEN2015 IN2015DN01700A (enrdf_load_stackoverflow) | 2012-08-03 | 2013-08-05 |
Country Status (9)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104904661B (zh) * | 2015-06-05 | 2018-07-24 | 杭州正因生物技术有限公司 | 一种人源化小鼠 |
| US11072649B2 (en) | 2015-11-25 | 2021-07-27 | Sab, Llc | Systems and methods for the production of human polyclonal antibodies |
| WO2018079857A1 (ja) * | 2016-10-31 | 2018-05-03 | 国立大学法人鳥取大学 | ヒト抗体産生非ヒト動物及びそれを用いたヒト抗体作製法 |
| WO2019015677A1 (en) * | 2017-07-21 | 2019-01-24 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED IMMUNOGLOBULIN HEAVY CHAIN ANIMALS |
| CN108486126A (zh) * | 2018-03-27 | 2018-09-04 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在人源化抗体中的应用 |
| CN108486125B (zh) * | 2018-03-27 | 2024-01-05 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在制备人源单域抗体中的应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN110128524B (zh) * | 2019-06-04 | 2021-05-07 | 中国农业科学院兰州兽医研究所 | 猪IgA+ B细胞类别转换标志物序列及检测方法 |
| US20210246197A1 (en) * | 2020-02-12 | 2021-08-12 | Sab, Llc. | Anti-thymocyte globulin |
| WO2022046286A1 (en) | 2020-08-31 | 2022-03-03 | SAB Biotherapeutics, Inc. | Ungulate-derived polyclonal immunoglobulin specific for coronavirus protein and uses thereof |
| US20230406934A1 (en) * | 2020-11-13 | 2023-12-21 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for pd-li and uses thereof |
| EP4243870A4 (en) * | 2020-11-13 | 2024-12-18 | Sab, Llc | UNGLILATE-DERIVED POLYCLONAL IMMUNGLOBULIN SPECIFIC TO EGFR AND USES THEREOF |
| WO2023102398A2 (en) * | 2021-11-30 | 2023-06-08 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof |
| US20240279315A1 (en) | 2023-02-17 | 2024-08-22 | Sab, Llc | Ungulate-derived polyclonal immunoglobulin specific for influenza virus and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| US7414170B2 (en) | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| CA2428053C (en) | 2000-11-17 | 2012-08-21 | Hematech, Llc | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
| AU2002309063B8 (en) * | 2001-05-11 | 2008-04-24 | Kyowa Kirin Co., Ltd. | Artificial human chromosome containing human antibody lambda light chain gene |
| CN1668187A (zh) * | 2002-05-17 | 2005-09-14 | 赫马技术有限公司 | 能够产生人抗体的转基因有蹄动物 |
| AU2004257292A1 (en) | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| WO2010003990A1 (en) * | 2008-07-10 | 2010-01-14 | Frewitt Fabrique De Machines S.A. | Bead mill with separator |
| CA3038954A1 (en) * | 2008-09-30 | 2010-04-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| DK2792236T4 (da) | 2009-07-08 | 2023-05-15 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| WO2011062207A1 (ja) * | 2009-11-17 | 2011-05-26 | 協和発酵キリン株式会社 | ヒト人工染色体ベクター |
| JP6029019B2 (ja) * | 2011-05-13 | 2016-11-24 | 国立大学法人 宮崎大学 | 細胞接着阻害剤、細胞増殖阻害剤、並びに癌の検査方法および検査用キット |
-
2013
- 2013-08-05 WO PCT/US2013/053618 patent/WO2014022853A1/en active Application Filing
- 2013-08-05 NZ NZ703973A patent/NZ703973A/en unknown
- 2013-08-05 KR KR1020157005433A patent/KR102159163B1/ko active Active
- 2013-08-05 AU AU2013296182A patent/AU2013296182B2/en active Active
- 2013-08-05 CN CN201380041315.4A patent/CN104755493B/zh active Active
- 2013-08-05 JP JP2015525643A patent/JP6426606B2/ja active Active
- 2013-08-05 IN IN1700DEN2015 patent/IN2015DN01700A/en unknown
- 2013-08-05 US US14/416,870 patent/US9902970B2/en active Active
- 2013-08-05 EP EP13747631.3A patent/EP2880055B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1210621A1 (en) | 2016-04-29 |
| JP2016504012A (ja) | 2016-02-12 |
| WO2014022853A1 (en) | 2014-02-06 |
| EP2880055B1 (en) | 2017-06-28 |
| CN104755493B (zh) | 2020-12-25 |
| AU2013296182A1 (en) | 2015-02-19 |
| US9902970B2 (en) | 2018-02-27 |
| KR20150039820A (ko) | 2015-04-13 |
| NZ703973A (en) | 2018-04-27 |
| EP2880055A1 (en) | 2015-06-10 |
| JP6426606B2 (ja) | 2018-11-21 |
| AU2013296182B2 (en) | 2018-03-08 |
| US20150211020A1 (en) | 2015-07-30 |
| CN104755493A (zh) | 2015-07-01 |
| KR102159163B1 (ko) | 2020-09-23 |
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