IN2014DN09392A - - Google Patents
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- Publication number
- IN2014DN09392A IN2014DN09392A IN9392DEN2014A IN2014DN09392A IN 2014DN09392 A IN2014DN09392 A IN 2014DN09392A IN 9392DEN2014 A IN9392DEN2014 A IN 9392DEN2014A IN 2014DN09392 A IN2014DN09392 A IN 2014DN09392A
- Authority
- IN
- India
- Prior art keywords
- compounds
- essentially pure
- xxv
- stimulating
- formulas
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000356 contaminant Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623393P | 2012-04-12 | 2012-04-12 | |
| US13/842,424 US9241988B2 (en) | 2012-04-12 | 2013-03-15 | Disaccharide synthetic lipid compounds and uses thereof |
| PCT/US2013/036425 WO2013155448A1 (en) | 2012-04-12 | 2013-04-12 | Disaccharide synthetic lipid compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09392A true IN2014DN09392A (enExample) | 2015-07-17 |
Family
ID=49325307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9392DEN2014 IN2014DN09392A (enExample) | 2012-04-12 | 2013-04-12 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9241988B2 (enExample) |
| EP (2) | EP2836499B1 (enExample) |
| JP (3) | JP6271510B2 (enExample) |
| CN (2) | CN104470938B (enExample) |
| CA (1) | CA2870008C (enExample) |
| DK (1) | DK3674309T3 (enExample) |
| ES (2) | ES2787876T3 (enExample) |
| IN (1) | IN2014DN09392A (enExample) |
| WO (1) | WO2013155448A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2484375T (lt) | 2006-09-26 | 2018-07-10 | Infectious Disease Research Institute | Vakcinos kompozicija, turinti sintetinio adjuvanto |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| EA034351B1 (ru) | 2012-05-16 | 2020-01-30 | Иммьюн Дизайн Корп. | Трехкомпонентная вакцина против впг-2 и способы ее применения |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US20150086592A1 (en) | 2013-09-25 | 2015-03-26 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EP3191123B1 (en) * | 2014-09-12 | 2020-06-03 | Bestewil Holding B.v. | Methods for providing adjuvanted virosomes and adjuvanted virosomes obtainable thereby |
| EP3069729A1 (en) * | 2015-03-17 | 2016-09-21 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2016149417A1 (en) * | 2015-03-17 | 2016-09-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EP3849521A1 (en) | 2018-09-14 | 2021-07-21 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| US20220339282A1 (en) * | 2018-11-29 | 2022-10-27 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
| CA3161857A1 (en) | 2019-11-22 | 2021-05-27 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
| US20230190920A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| WO2024064783A1 (en) | 2022-09-21 | 2024-03-28 | Wisconsin Alumni Research Foundation | Compositions and methods to enhance therapeutic efficacy of cancer therapies |
| WO2024151642A1 (en) * | 2023-01-09 | 2024-07-18 | University Of Maryland, Baltimore | Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066794A (en) | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| JP2535048B2 (ja) | 1988-02-29 | 1996-09-18 | 第一製薬株式会社 | 新規ジサッカライド誘導体及びその塩 |
| JPH06206893A (ja) * | 1992-09-07 | 1994-07-26 | Suntory Ltd | 新規なジサッカライド誘導体 |
| AU679970B2 (en) | 1993-09-07 | 1997-07-17 | Suntory Limited | Novel disaccharide derivative |
| JP3967769B2 (ja) * | 1993-11-17 | 2007-08-29 | オーエム・ファルマ | グルコサミンジサッカライド、それらの製造法、それらを含む医薬組成物およびそれらの使用 |
| JPH10152497A (ja) * | 1996-09-30 | 1998-06-09 | Otsuka Pharmaceut Factory Inc | ヘリコバクター・ピロリのリピドａ |
| KR100682154B1 (ko) * | 1998-05-07 | 2007-02-12 | 코릭사 코포레이션 | 아쥬번트 조성물 및 그의 사용방법 |
| CA2333578C (en) * | 1998-07-14 | 2010-11-16 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid a |
| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| CA2396744C (en) * | 1999-11-15 | 2011-07-12 | Biomira, Inc. | Synthetic lipid-a analogs and uses thereof |
| BR0110975A (pt) * | 2000-05-19 | 2004-03-23 | Corixa Corp | Tratamento profilático e terapêutico de doenças infecciosas ou outras doenças com compostos à base de mono- e disacarìdeos |
| CN1907289A (zh) * | 2000-05-19 | 2007-02-07 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| US20030031684A1 (en) * | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| GB0420634D0 (en) * | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| US8563523B2 (en) | 2007-09-07 | 2013-10-22 | University Of Georgia Research Foundation, Inc. | Synthetic lipid A derivative |
| PT2222710T (pt) * | 2007-12-24 | 2016-11-02 | Glaxosmithkline Biologicals Sa | Antigénios de rsv recombinantes |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
-
2013
- 2013-03-15 US US13/842,424 patent/US9241988B2/en active Active
- 2013-04-12 ES ES13775926T patent/ES2787876T3/es active Active
- 2013-04-12 CA CA2870008A patent/CA2870008C/en active Active
- 2013-04-12 IN IN9392DEN2014 patent/IN2014DN09392A/en unknown
- 2013-04-12 DK DK20157427.4T patent/DK3674309T3/da active
- 2013-04-12 EP EP13775926.2A patent/EP2836499B1/en active Active
- 2013-04-12 CN CN201380026285.XA patent/CN104470938B/zh active Active
- 2013-04-12 ES ES20157427T patent/ES2992314T3/es active Active
- 2013-04-12 JP JP2015505953A patent/JP6271510B2/ja active Active
- 2013-04-12 CN CN201710534045.0A patent/CN107412766A/zh active Pending
- 2013-04-12 WO PCT/US2013/036425 patent/WO2013155448A1/en not_active Ceased
- 2013-04-12 EP EP20157427.4A patent/EP3674309B1/en active Active
-
2016
- 2016-01-26 US US15/006,938 patent/US10143744B2/en active Active
-
2017
- 2017-12-26 JP JP2017248795A patent/JP6764396B2/ja active Active
-
2020
- 2020-05-26 JP JP2020091157A patent/JP7189906B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018070652A (ja) | 2018-05-10 |
| CN104470938B (zh) | 2017-07-28 |
| JP6764396B2 (ja) | 2020-09-30 |
| CN104470938A (zh) | 2015-03-25 |
| DK3674309T3 (da) | 2024-11-25 |
| ES2992314T3 (es) | 2024-12-11 |
| CA2870008A1 (en) | 2013-10-17 |
| CN107412766A (zh) | 2017-12-01 |
| EP3674309B1 (en) | 2024-09-11 |
| EP2836499A4 (en) | 2015-11-25 |
| US20160136271A1 (en) | 2016-05-19 |
| WO2013155448A1 (en) | 2013-10-17 |
| EP2836499B1 (en) | 2020-02-26 |
| JP2015512946A (ja) | 2015-04-30 |
| CA2870008C (en) | 2021-05-04 |
| EP2836499A1 (en) | 2015-02-18 |
| JP2020147579A (ja) | 2020-09-17 |
| US20130273149A1 (en) | 2013-10-17 |
| JP7189906B2 (ja) | 2022-12-14 |
| ES2787876T3 (es) | 2020-10-19 |
| HK1207383A1 (en) | 2016-01-29 |
| JP6271510B2 (ja) | 2018-01-31 |
| US10143744B2 (en) | 2018-12-04 |
| US9241988B2 (en) | 2016-01-26 |
| EP3674309A1 (en) | 2020-07-01 |
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