JP6271510B2 - 二糖合成脂質化合物およびその使用 - Google Patents

二糖合成脂質化合物およびその使用 Download PDF

Info

Publication number
JP6271510B2
JP6271510B2 JP2015505953A JP2015505953A JP6271510B2 JP 6271510 B2 JP6271510 B2 JP 6271510B2 JP 2015505953 A JP2015505953 A JP 2015505953A JP 2015505953 A JP2015505953 A JP 2015505953A JP 6271510 B2 JP6271510 B2 JP 6271510B2
Authority
JP
Japan
Prior art keywords
compound
diglycolipid
synthetic
unsubstituted alkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015505953A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015512946A (ja
JP2015512946A5 (enExample
Inventor
ショウ，ウォルター・エイ
バージェス，スティーブン・ダブリュ
リー，シェンロン
ヒックマン，デイビッド・ティー
ロペス−デベル，マリア・ピラール
Original Assignee
アバンティ・ポーラ・リピッド・インコーポレイテッド
エーシー イミューン エス．エー．
エーシー イミューン エス．エー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アバンティ・ポーラ・リピッド・インコーポレイテッド, エーシー イミューン エス．エー．, エーシー イミューン エス．エー． filed Critical アバンティ・ポーラ・リピッド・インコーポレイテッド
Publication of JP2015512946A publication Critical patent/JP2015512946A/ja
Publication of JP2015512946A5 publication Critical patent/JP2015512946A5/ja
Application granted granted Critical
Publication of JP6271510B2 publication Critical patent/JP6271510B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015505953A 2012-04-12 2013-04-12 二糖合成脂質化合物およびその使用 Active JP6271510B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261623393P 2012-04-12 2012-04-12
US61/623,393 2012-04-12
US13/842,424 2013-03-15
US13/842,424 US9241988B2 (en) 2012-04-12 2013-03-15 Disaccharide synthetic lipid compounds and uses thereof
PCT/US2013/036425 WO2013155448A1 (en) 2012-04-12 2013-04-12 Disaccharide synthetic lipid compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017248795A Division JP6764396B2 (ja) 2012-04-12 2017-12-26 二糖合成脂質化合物およびその使用

Publications (3)

Publication Number Publication Date
JP2015512946A JP2015512946A (ja) 2015-04-30
JP2015512946A5 JP2015512946A5 (enExample) 2016-04-28
JP6271510B2 true JP6271510B2 (ja) 2018-01-31

Family

ID=49325307

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015505953A Active JP6271510B2 (ja) 2012-04-12 2013-04-12 二糖合成脂質化合物およびその使用
JP2017248795A Active JP6764396B2 (ja) 2012-04-12 2017-12-26 二糖合成脂質化合物およびその使用
JP2020091157A Active JP7189906B2 (ja) 2012-04-12 2020-05-26 二糖合成脂質化合物およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017248795A Active JP6764396B2 (ja) 2012-04-12 2017-12-26 二糖合成脂質化合物およびその使用
JP2020091157A Active JP7189906B2 (ja) 2012-04-12 2020-05-26 二糖合成脂質化合物およびその使用

Country Status (9)

Country Link
US (2) US9241988B2 (enExample)
EP (2) EP3674309B1 (enExample)
JP (3) JP6271510B2 (enExample)
CN (2) CN107412766A (enExample)
CA (1) CA2870008C (enExample)
DK (1) DK3674309T3 (enExample)
ES (2) ES2992314T3 (enExample)
IN (1) IN2014DN09392A (enExample)
WO (1) WO2013155448A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101378872B1 (ko) 2006-09-26 2014-04-11 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) 합성 애주번트를 함유하는 백신 조성물
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
PT2850431T (pt) 2012-05-16 2018-07-23 Immune Design Corp Vacinas para hsv-2
US9504743B2 (en) 2013-09-25 2016-11-29 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149521B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US20150086592A1 (en) 2013-09-25 2015-03-26 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149522B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
CN107073105B (zh) * 2014-09-12 2021-04-06 巴斯特威尔控股有限公司 用于提供含佐剂病毒体的方法及由此可获得的含佐剂病毒体
EP3069729A1 (en) * 2015-03-17 2016-09-21 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
WO2016149417A1 (en) * 2015-03-17 2016-09-22 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
EP3849521A1 (en) 2018-09-14 2021-07-21 Massachusetts Institute Of Technology Nanoparticle vaccine adjuvant and methods of use thereof
US12016885B2 (en) 2018-11-06 2024-06-25 Alsatech, Inc. Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab
WO2020109365A1 (en) 2018-11-29 2020-06-04 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
BR112022008761A2 (pt) 2019-11-22 2022-07-26 Glaxosmithkline Biologicals Sa Dosagem e administração de uma vacina de glicoconjugado de sacarídeo
US20230190920A1 (en) 2021-12-19 2023-06-22 Massachusetts Institute Of Technology Compositions and methods for long-lasting germinal center responses to a priming immunization
EP4590402A1 (en) 2022-09-21 2025-07-30 Wisconsin Alumni Research Foundation Compositions and methods to enhance therapeutic efficacy of cancer therapies
WO2024151642A1 (en) * 2023-01-09 2024-07-18 University Of Maryland, Baltimore Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency
WO2026087792A1 (en) 2024-10-27 2026-04-30 Idorsia Pharmaceuticals Ltd Vaccine against klebsiella pneumoniae

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066794A (en) 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
GR860379B (en) * 1985-02-22 1986-06-11 Akzo Nv Novel disaccharide and trisaccharide derivatives of the lipid a type
JP2535048B2 (ja) 1988-02-29 1996-09-18 第一製薬株式会社 新規ジサッカライド誘導体及びその塩
JPH06206893A (ja) * 1992-09-07 1994-07-26 Suntory Ltd 新規なジサッカライド誘導体
AU679970B2 (en) 1993-09-07 1997-07-17 Suntory Limited Novel disaccharide derivative
JP3967769B2 (ja) * 1993-11-17 2007-08-29 オーエム・ファルマ グルコサミンジサッカライド、それらの製造法、それらを含む医薬組成物およびそれらの使用
JPH10152497A (ja) * 1996-09-30 1998-06-09 Otsuka Pharmaceut Factory Inc ヘリコバクター・ピロリのリピドａ
HK1039072A1 (zh) * 1998-05-07 2002-04-12 科里克萨有限公司 佐剂组合物及其使用方法
AU763770B2 (en) * 1998-07-14 2003-07-31 Wyeth Holdings Corporation Adjuvant and vaccine compositions containing monophosphoryl lipid A
US20020022032A1 (en) * 1999-04-23 2002-02-21 Curry Patrick Mark Immuno-adjuvant PDT treatment of metastatic tumors
AU780577B2 (en) * 1999-11-15 2005-04-07 Oncothyreon Inc. Synthetic Lipid-A analogs and uses thereof
WO2001090129A2 (en) * 2000-05-19 2001-11-29 Corixa Corporation Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with mono and disaccharide-base compounds
CN1907289A (zh) * 2000-05-19 2007-02-07 科里克萨有限公司 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法
US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
GB0420634D0 (en) * 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
US7622128B2 (en) * 2005-12-13 2009-11-24 University Of Washington Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
WO2008059307A2 (en) * 2006-11-16 2008-05-22 Om Pharma Functionalized beta 1,6 glucosamine disaccharides and process for their preparation
WO2009035528A2 (en) * 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
KR101617895B1 (ko) * 2007-12-24 2016-05-03 글락소스미스클라인 바이오로지칼즈 에스.에이. 재조합 ｒｓｖ 항원
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof

Also Published As

Publication number Publication date
JP6764396B2 (ja) 2020-09-30
JP2020147579A (ja) 2020-09-17
CN107412766A (zh) 2017-12-01
JP2015512946A (ja) 2015-04-30
EP2836499B1 (en) 2020-02-26
JP7189906B2 (ja) 2022-12-14
EP3674309A1 (en) 2020-07-01
JP2018070652A (ja) 2018-05-10
WO2013155448A1 (en) 2013-10-17
US10143744B2 (en) 2018-12-04
IN2014DN09392A (enExample) 2015-07-17
US9241988B2 (en) 2016-01-26
DK3674309T3 (da) 2024-11-25
CN104470938B (zh) 2017-07-28
US20160136271A1 (en) 2016-05-19
EP2836499A1 (en) 2015-02-18
CA2870008A1 (en) 2013-10-17
CN104470938A (zh) 2015-03-25
ES2787876T3 (es) 2020-10-19
EP3674309B1 (en) 2024-09-11
US20130273149A1 (en) 2013-10-17
ES2992314T3 (es) 2024-12-11
CA2870008C (en) 2021-05-04
EP2836499A4 (en) 2015-11-25
HK1207383A1 (en) 2016-01-29

Similar Documents

Publication Publication Date Title
JP7189906B2 (ja) 二糖合成脂質化合物およびその使用
US9518078B2 (en) Disaccharide synthetic lipid compounds and uses thereof
JP7386536B2 (ja) アルキル鎖修飾イミダゾキノリンｔｌｒ７／８アゴニスト化合物およびその使用
CN1997395B (zh) 含有包含在脂质体中的调节性细胞配体的药物
US4117113A (en) Immunological preparations
JP5778725B2 (ja) 合成アジュバントを含むワクチン組成物
WO2016176558A1 (en) Adjuvant particles comprising adenosine receptor antagonists
JP2016531853A (ja) 抗原特異的免疫原性を低減するための組成物及び方法
US20220257752A1 (en) New use of cyclic dinucleotides
WO2008026781A1 (en) Reverse targeting lipid vesicle
US20170349618A1 (en) Disaccharide synthetic lipid compounds and uses thereof
HK1207383B (en) Disaccharide synthetic lipid compounds and uses thereof
US20110104248A1 (en) Liposomes and immunopotentiating compositions containing the same
JP4092367B1 (ja) リポソームおよびこれを含む免疫賦活活性用組成物。
US20090306019A1 (en) Compositions for treatment of eosinophilia and related disorders
WO2025157144A1 (zh) 经黏膜给药的水包油乳液
WO2025221606A1 (en) Lipids for hyperactivation of mammalian dendritic cells
TW202342094A (zh) 高度活化之脂質奈米粒子
Gameiro et al. Pulmonary delivery of liposome-based GST1194 conformational variants: implications for vaccine development against Schistosoma mansoni infection

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160310

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160310

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170404

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170630

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171004

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20171128

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20171227

R150 Certificate of patent or registration of utility model

Ref document number: 6271510

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250