CN107412766A - 二糖合成脂质化合物及其用途 - Google Patents
二糖合成脂质化合物及其用途 Download PDFInfo
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- CN107412766A CN107412766A CN201710534045.0A CN201710534045A CN107412766A CN 107412766 A CN107412766 A CN 107412766A CN 201710534045 A CN201710534045 A CN 201710534045A CN 107412766 A CN107412766 A CN 107412766A
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- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
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- Neurology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| CN201380026285.XA CN104470938B (zh) | 2012-04-12 | 2013-04-12 | 二糖合成脂质化合物及其用途 |
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| PT2484375T (pt) | 2006-09-26 | 2018-07-09 | Infectious Disease Res Inst | Composição para vacina contendo adjuvante sintético |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| US9555099B2 (en) | 2012-05-16 | 2017-01-31 | Immune Design Corp. | Vaccines for HSV-2 |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US20150086592A1 (en) | 2013-09-25 | 2015-03-26 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EP3191123B1 (en) * | 2014-09-12 | 2020-06-03 | Bestewil Holding B.v. | Methods for providing adjuvanted virosomes and adjuvanted virosomes obtainable thereby |
| EP3069729A1 (en) * | 2015-03-17 | 2016-09-21 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EP3270962A4 (en) * | 2015-03-17 | 2018-08-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2020055503A1 (en) | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| CN113508127A (zh) | 2018-11-06 | 2021-10-15 | 阿尔萨泰克公司 | 神经变性疾病的基于细胞的基因疗法 |
| WO2020109365A1 (en) | 2018-11-29 | 2020-06-04 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
| MX2022006054A (es) | 2019-11-22 | 2022-06-24 | Glaxosmithkline Biologicals Sa | Dosificacion y administracion de una vacuna de glucoconjugados de sacaridos bacterianos. |
| WO2023114570A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| US20240173401A1 (en) | 2022-09-21 | 2024-05-30 | Wisconsin Alumni Research Foundation | Compositions and Methods to Enhance Therapeutic Efficacy of Cancer Therapies |
| WO2024151642A1 (en) * | 2023-01-09 | 2024-07-18 | University Of Maryland, Baltimore | Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency |
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| FI860747A7 (fi) * | 1985-02-22 | 1986-08-23 | Akzo Nv | Nya 'lipid a'-typ disackarid- och trisackaridderivat. |
| WO2001036433A2 (en) * | 1999-11-15 | 2001-05-25 | Biomira, Inc. | Synthetic lipid-a analogs and uses thereof |
| CN1306438A (zh) * | 1998-05-07 | 2001-08-01 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| CN1606446A (zh) * | 2000-05-19 | 2005-04-13 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| CN1907289A (zh) * | 2000-05-19 | 2007-02-07 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| CN1928107A (zh) * | 2001-03-30 | 2007-03-14 | 利里克萨有限公司 | 生产3－o－钝化－4’－单磷酰基脂a(3d－mla)的方法 |
| WO2009035528A2 (en) * | 2007-09-07 | 2009-03-19 | University Of Georgia Research Foundation, Inc. | Synthetic lipid a derivative |
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| US5066794A (en) | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| JP2535048B2 (ja) | 1988-02-29 | 1996-09-18 | 第一製薬株式会社 | 新規ジサッカライド誘導体及びその塩 |
| JPH06206893A (ja) * | 1992-09-07 | 1994-07-26 | Suntory Ltd | 新規なジサッカライド誘導体 |
| AU679970B2 (en) | 1993-09-07 | 1997-07-17 | Suntory Limited | Novel disaccharide derivative |
| AU700485B2 (en) * | 1993-11-17 | 1999-01-07 | Om Pharma | Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use |
| JPH10152497A (ja) * | 1996-09-30 | 1998-06-09 | Otsuka Pharmaceut Factory Inc | ヘリコバクター・ピロリのリピドａ |
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| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| GB0420634D0 (en) * | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| EP4206231A1 (en) * | 2007-12-24 | 2023-07-05 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
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2013
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- 2013-04-12 ES ES20157427T patent/ES2992314T3/es active Active
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- 2013-04-12 IN IN9392DEN2014 patent/IN2014DN09392A/en unknown
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- 2013-04-12 WO PCT/US2013/036425 patent/WO2013155448A1/en not_active Ceased
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- 2013-04-12 JP JP2015505953A patent/JP6271510B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CN104470938B (zh) | 2017-07-28 |
| CN104470938A (zh) | 2015-03-25 |
| JP6764396B2 (ja) | 2020-09-30 |
| JP2020147579A (ja) | 2020-09-17 |
| IN2014DN09392A (enExample) | 2015-07-17 |
| JP2018070652A (ja) | 2018-05-10 |
| US9241988B2 (en) | 2016-01-26 |
| HK1207383A1 (en) | 2016-01-29 |
| ES2787876T3 (es) | 2020-10-19 |
| JP2015512946A (ja) | 2015-04-30 |
| EP3674309A1 (en) | 2020-07-01 |
| DK3674309T3 (da) | 2024-11-25 |
| EP2836499A4 (en) | 2015-11-25 |
| ES2992314T3 (es) | 2024-12-11 |
| JP7189906B2 (ja) | 2022-12-14 |
| US20160136271A1 (en) | 2016-05-19 |
| EP2836499A1 (en) | 2015-02-18 |
| EP2836499B1 (en) | 2020-02-26 |
| US20130273149A1 (en) | 2013-10-17 |
| CA2870008C (en) | 2021-05-04 |
| WO2013155448A1 (en) | 2013-10-17 |
| JP6271510B2 (ja) | 2018-01-31 |
| EP3674309B1 (en) | 2024-09-11 |
| US10143744B2 (en) | 2018-12-04 |
| CA2870008A1 (en) | 2013-10-17 |
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