DK3674309T3 - Disaccharid syntetiske lipidforbindelser og anvendelser heraf - Google Patents
Disaccharid syntetiske lipidforbindelser og anvendelser heraf Download PDFInfo
- Publication number
- DK3674309T3 DK3674309T3 DK20157427.4T DK20157427T DK3674309T3 DK 3674309 T3 DK3674309 T3 DK 3674309T3 DK 20157427 T DK20157427 T DK 20157427T DK 3674309 T3 DK3674309 T3 DK 3674309T3
- Authority
- DK
- Denmark
- Prior art keywords
- lipid compounds
- synthetic lipid
- disaccharide
- disaccharide synthetic
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623393P | 2012-04-12 | 2012-04-12 | |
| US13/842,424 US9241988B2 (en) | 2012-04-12 | 2013-03-15 | Disaccharide synthetic lipid compounds and uses thereof |
| EP13775926.2A EP2836499B1 (en) | 2012-04-12 | 2013-04-12 | Disaccharide synthetic lipid compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3674309T3 true DK3674309T3 (da) | 2024-11-25 |
Family
ID=49325307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20157427.4T DK3674309T3 (da) | 2012-04-12 | 2013-04-12 | Disaccharid syntetiske lipidforbindelser og anvendelser heraf |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9241988B2 (enExample) |
| EP (2) | EP3674309B1 (enExample) |
| JP (3) | JP6271510B2 (enExample) |
| CN (2) | CN107412766A (enExample) |
| CA (1) | CA2870008C (enExample) |
| DK (1) | DK3674309T3 (enExample) |
| ES (2) | ES2992314T3 (enExample) |
| IN (1) | IN2014DN09392A (enExample) |
| WO (1) | WO2013155448A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101378872B1 (ko) | 2006-09-26 | 2014-04-11 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 합성 애주번트를 함유하는 백신 조성물 |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| PT2850431T (pt) | 2012-05-16 | 2018-07-23 | Immune Design Corp | Vacinas para hsv-2 |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US20150086592A1 (en) | 2013-09-25 | 2015-03-26 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| CN107073105B (zh) * | 2014-09-12 | 2021-04-06 | 巴斯特威尔控股有限公司 | 用于提供含佐剂病毒体的方法及由此可获得的含佐剂病毒体 |
| EP3069729A1 (en) * | 2015-03-17 | 2016-09-21 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2016149417A1 (en) * | 2015-03-17 | 2016-09-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| EP3849521A1 (en) | 2018-09-14 | 2021-07-21 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| US12016885B2 (en) | 2018-11-06 | 2024-06-25 | Alsatech, Inc. | Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab |
| WO2020109365A1 (en) | 2018-11-29 | 2020-06-04 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
| BR112022008761A2 (pt) | 2019-11-22 | 2022-07-26 | Glaxosmithkline Biologicals Sa | Dosagem e administração de uma vacina de glicoconjugado de sacarídeo |
| US20230190920A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| EP4590402A1 (en) | 2022-09-21 | 2025-07-30 | Wisconsin Alumni Research Foundation | Compositions and methods to enhance therapeutic efficacy of cancer therapies |
| WO2024151642A1 (en) * | 2023-01-09 | 2024-07-18 | University Of Maryland, Baltimore | Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency |
| WO2026087792A1 (en) | 2024-10-27 | 2026-04-30 | Idorsia Pharmaceuticals Ltd | Vaccine against klebsiella pneumoniae |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066794A (en) | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| JP2535048B2 (ja) | 1988-02-29 | 1996-09-18 | 第一製薬株式会社 | 新規ジサッカライド誘導体及びその塩 |
| JPH06206893A (ja) * | 1992-09-07 | 1994-07-26 | Suntory Ltd | 新規なジサッカライド誘導体 |
| AU679970B2 (en) | 1993-09-07 | 1997-07-17 | Suntory Limited | Novel disaccharide derivative |
| JP3967769B2 (ja) * | 1993-11-17 | 2007-08-29 | オーエム・ファルマ | グルコサミンジサッカライド、それらの製造法、それらを含む医薬組成物およびそれらの使用 |
| JPH10152497A (ja) * | 1996-09-30 | 1998-06-09 | Otsuka Pharmaceut Factory Inc | ヘリコバクター・ピロリのリピドａ |
| HK1039072A1 (zh) * | 1998-05-07 | 2002-04-12 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| AU763770B2 (en) * | 1998-07-14 | 2003-07-31 | Wyeth Holdings Corporation | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| AU780577B2 (en) * | 1999-11-15 | 2005-04-07 | Oncothyreon Inc. | Synthetic Lipid-A analogs and uses thereof |
| WO2001090129A2 (en) * | 2000-05-19 | 2001-11-29 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with mono and disaccharide-base compounds |
| CN1907289A (zh) * | 2000-05-19 | 2007-02-07 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| US20030031684A1 (en) * | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| GB0420634D0 (en) * | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| WO2009035528A2 (en) * | 2007-09-07 | 2009-03-19 | University Of Georgia Research Foundation, Inc. | Synthetic lipid a derivative |
| KR101617895B1 (ko) * | 2007-12-24 | 2016-05-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 재조합 ｒｓｖ 항원 |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
-
2013
- 2013-03-15 US US13/842,424 patent/US9241988B2/en active Active
- 2013-04-12 EP EP20157427.4A patent/EP3674309B1/en active Active
- 2013-04-12 CA CA2870008A patent/CA2870008C/en active Active
- 2013-04-12 WO PCT/US2013/036425 patent/WO2013155448A1/en not_active Ceased
- 2013-04-12 EP EP13775926.2A patent/EP2836499B1/en active Active
- 2013-04-12 IN IN9392DEN2014 patent/IN2014DN09392A/en unknown
- 2013-04-12 ES ES20157427T patent/ES2992314T3/es active Active
- 2013-04-12 CN CN201710534045.0A patent/CN107412766A/zh active Pending
- 2013-04-12 DK DK20157427.4T patent/DK3674309T3/da active
- 2013-04-12 CN CN201380026285.XA patent/CN104470938B/zh active Active
- 2013-04-12 JP JP2015505953A patent/JP6271510B2/ja active Active
- 2013-04-12 ES ES13775926T patent/ES2787876T3/es active Active
-
2016
- 2016-01-26 US US15/006,938 patent/US10143744B2/en active Active
-
2017
- 2017-12-26 JP JP2017248795A patent/JP6764396B2/ja active Active
-
2020
- 2020-05-26 JP JP2020091157A patent/JP7189906B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6764396B2 (ja) | 2020-09-30 |
| JP2020147579A (ja) | 2020-09-17 |
| CN107412766A (zh) | 2017-12-01 |
| JP6271510B2 (ja) | 2018-01-31 |
| JP2015512946A (ja) | 2015-04-30 |
| EP2836499B1 (en) | 2020-02-26 |
| JP7189906B2 (ja) | 2022-12-14 |
| EP3674309A1 (en) | 2020-07-01 |
| JP2018070652A (ja) | 2018-05-10 |
| WO2013155448A1 (en) | 2013-10-17 |
| US10143744B2 (en) | 2018-12-04 |
| IN2014DN09392A (enExample) | 2015-07-17 |
| US9241988B2 (en) | 2016-01-26 |
| CN104470938B (zh) | 2017-07-28 |
| US20160136271A1 (en) | 2016-05-19 |
| EP2836499A1 (en) | 2015-02-18 |
| CA2870008A1 (en) | 2013-10-17 |
| CN104470938A (zh) | 2015-03-25 |
| ES2787876T3 (es) | 2020-10-19 |
| EP3674309B1 (en) | 2024-09-11 |
| US20130273149A1 (en) | 2013-10-17 |
| ES2992314T3 (es) | 2024-12-11 |
| CA2870008C (en) | 2021-05-04 |
| EP2836499A4 (en) | 2015-11-25 |
| HK1207383A1 (en) | 2016-01-29 |
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