ES2787876T3 - Compuestos lipídicos disacáridos sintéticos y usos de los mismos - Google Patents
Compuestos lipídicos disacáridos sintéticos y usos de los mismos Download PDFInfo
- Publication number
- ES2787876T3 ES2787876T3 ES13775926T ES13775926T ES2787876T3 ES 2787876 T3 ES2787876 T3 ES 2787876T3 ES 13775926 T ES13775926 T ES 13775926T ES 13775926 T ES13775926 T ES 13775926T ES 2787876 T3 ES2787876 T3 ES 2787876T3
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- alkyl
- unsubstituted
- representation
- compounds
- synthetic disaccharide
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- A61K39/0005—Vertebrate antigens
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/US2013/036425 WO2013155448A1 (en) | 2012-04-12 | 2013-04-12 | Disaccharide synthetic lipid compounds and uses thereof |
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| WO2008153541A1 (en) | 2006-09-26 | 2008-12-18 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| AU2013262691B2 (en) | 2012-05-16 | 2018-12-20 | Immune Design Corp. | Vaccines for HSV-2 |
| US20150086592A1 (en) | 2013-09-25 | 2015-03-26 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149521B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| RU2694367C2 (ru) * | 2014-09-12 | 2019-07-12 | Бестевил Холдинг Б.В. | Способы получения адъювантных виросом и адъювантные виросомы, получаемые указанными способами |
| EP3069729A1 (en) * | 2015-03-17 | 2016-09-21 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2016149417A1 (en) * | 2015-03-17 | 2016-09-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US11547672B2 (en) | 2018-09-14 | 2023-01-10 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| EP3877399A4 (en) | 2018-11-06 | 2022-10-19 | Alsatech, Inc. | CELL-BASED GENE THERAPY FOR NEURODEGENERATIVE DISEASES |
| EP3886901A1 (en) * | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| CN114728051A (zh) | 2019-11-22 | 2022-07-08 | 葛兰素史克生物有限公司 | 细菌糖糖缀合物疫苗的剂量和施用 |
| US20230190920A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| EP4590402A1 (en) | 2022-09-21 | 2025-07-30 | Wisconsin Alumni Research Foundation | Compositions and methods to enhance therapeutic efficacy of cancer therapies |
| WO2024151642A1 (en) * | 2023-01-09 | 2024-07-18 | University Of Maryland, Baltimore | Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency |
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| US5066794A (en) | 1984-08-24 | 1991-11-19 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing a disaccharide derivative |
| GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
| JP2535048B2 (ja) | 1988-02-29 | 1996-09-18 | 第一製薬株式会社 | 新規ジサッカライド誘導体及びその塩 |
| JPH06206893A (ja) * | 1992-09-07 | 1994-07-26 | Suntory Ltd | 新規なジサッカライド誘導体 |
| CA2148824A1 (en) | 1993-09-07 | 1995-03-16 | Tohru Kodama | Novel disaccharide derivative |
| PL181241B1 (pl) * | 1993-11-17 | 2001-06-29 | Deutsche Om Arzneimittel Gmbh | Disacharydy beta(1 6)glukozoaminowe, sposób wytwarzania disacharydu beta(1 6) glukozoaminowego, zawierająca je kompozycja farmaceutyczna i środek immunomodulujący i/lub przeciwnowotworowy oraz szczepionka |
| JPH10152497A (ja) * | 1996-09-30 | 1998-06-09 | Otsuka Pharmaceut Factory Inc | ヘリコバクター・ピロリのリピドａ |
| CN1306438A (zh) * | 1998-05-07 | 2001-08-01 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| ES2229745T3 (es) | 1998-07-14 | 2005-04-16 | Wyeth Holdings Corporation | Composicionde adyuvante y vacuna que contienen monofosforil lipido a. |
| US20020022032A1 (en) * | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| ATE518874T1 (de) | 1999-11-15 | 2011-08-15 | Oncothyreon Inc | Synthetische lipid-a analogen und verwendungen davon |
| CA2409221C (en) * | 2000-05-19 | 2010-10-26 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds |
| CN1907289A (zh) * | 2000-05-19 | 2007-02-07 | 科里克萨有限公司 | 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法 |
| US20030031684A1 (en) * | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| GB0420634D0 (en) * | 2004-09-16 | 2004-10-20 | Glaxosmithkline Biolog Sa | Vaccines |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| WO2008059307A2 (en) * | 2006-11-16 | 2008-05-22 | Om Pharma | Functionalized beta 1,6 glucosamine disaccharides and process for their preparation |
| CA2698668A1 (en) | 2007-09-07 | 2009-03-19 | University Of Georgia Research Foundation, Inc. | Synthetic lipid a derivative |
| EP2222710B8 (en) * | 2007-12-24 | 2016-10-12 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
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| CA2870008A1 (en) | 2013-10-17 |
| US20160136271A1 (en) | 2016-05-19 |
| CN104470938A (zh) | 2015-03-25 |
| EP2836499A1 (en) | 2015-02-18 |
| JP2018070652A (ja) | 2018-05-10 |
| US20130273149A1 (en) | 2013-10-17 |
| HK1207383A1 (en) | 2016-01-29 |
| CN107412766A (zh) | 2017-12-01 |
| US9241988B2 (en) | 2016-01-26 |
| CA2870008C (en) | 2021-05-04 |
| EP2836499A4 (en) | 2015-11-25 |
| ES2992314T3 (es) | 2024-12-11 |
| EP3674309B1 (en) | 2024-09-11 |
| US10143744B2 (en) | 2018-12-04 |
| WO2013155448A1 (en) | 2013-10-17 |
| JP2020147579A (ja) | 2020-09-17 |
| DK3674309T3 (da) | 2024-11-25 |
| JP6764396B2 (ja) | 2020-09-30 |
| JP2015512946A (ja) | 2015-04-30 |
| EP3674309A1 (en) | 2020-07-01 |
| CN104470938B (zh) | 2017-07-28 |
| EP2836499B1 (en) | 2020-02-26 |
| JP7189906B2 (ja) | 2022-12-14 |
| JP6271510B2 (ja) | 2018-01-31 |
| IN2014DN09392A (enExample) | 2015-07-17 |
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