CN104470938B - 二糖合成脂质化合物及其用途 - Google Patents

二糖合成脂质化合物及其用途 Download PDF

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Publication number
CN104470938B
CN104470938B CN201380026285.XA CN201380026285A CN104470938B CN 104470938 B CN104470938 B CN 104470938B CN 201380026285 A CN201380026285 A CN 201380026285A CN 104470938 B CN104470938 B CN 104470938B
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CN
China
Prior art keywords
compound
synthetic
diglycolipid
unsubstituted alkyl
alkyl
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CN201380026285.XA
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English (en)
Chinese (zh)
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CN104470938A (zh
Inventor
沃尔特·A·肖
斯蒂芬·W·伯吉斯
盛荣·李
D·T·希克曼
M·P·洛佩兹德贝尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AC Immune SA
Avanti Polar Lipids Inc
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AC Immune SA
Avanti Polar Lipids Inc
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Application filed by AC Immune SA, Avanti Polar Lipids Inc filed Critical AC Immune SA
Priority to CN201710534045.0A priority Critical patent/CN107412766A/zh
Publication of CN104470938A publication Critical patent/CN104470938A/zh
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380026285.XA 2012-04-12 2013-04-12 二糖合成脂质化合物及其用途 Active CN104470938B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710534045.0A CN107412766A (zh) 2012-04-12 2013-04-12 二糖合成脂质化合物及其用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261623393P 2012-04-12 2012-04-12
US61/623,393 2012-04-12
US13/842,424 US9241988B2 (en) 2012-04-12 2013-03-15 Disaccharide synthetic lipid compounds and uses thereof
US13/842,424 2013-03-15
PCT/US2013/036425 WO2013155448A1 (en) 2012-04-12 2013-04-12 Disaccharide synthetic lipid compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710534045.0A Division CN107412766A (zh) 2012-04-12 2013-04-12 二糖合成脂质化合物及其用途

Publications (2)

Publication Number Publication Date
CN104470938A CN104470938A (zh) 2015-03-25
CN104470938B true CN104470938B (zh) 2017-07-28

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CN201380026285.XA Active CN104470938B (zh) 2012-04-12 2013-04-12 二糖合成脂质化合物及其用途
CN201710534045.0A Pending CN107412766A (zh) 2012-04-12 2013-04-12 二糖合成脂质化合物及其用途

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US (2) US9241988B2 (enExample)
EP (2) EP2836499B1 (enExample)
JP (3) JP6271510B2 (enExample)
CN (2) CN104470938B (enExample)
CA (1) CA2870008C (enExample)
DK (1) DK3674309T3 (enExample)
ES (2) ES2787876T3 (enExample)
IN (1) IN2014DN09392A (enExample)
WO (1) WO2013155448A1 (enExample)

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LT2484375T (lt) 2006-09-26 2018-07-10 Infectious Disease Research Institute Vakcinos kompozicija, turinti sintetinio adjuvanto
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
EA034351B1 (ru) 2012-05-16 2020-01-30 Иммьюн Дизайн Корп. Трехкомпонентная вакцина против впг-2 и способы ее применения
US9149522B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9504743B2 (en) 2013-09-25 2016-11-29 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149521B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US20150086592A1 (en) 2013-09-25 2015-03-26 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
EP3191123B1 (en) * 2014-09-12 2020-06-03 Bestewil Holding B.v. Methods for providing adjuvanted virosomes and adjuvanted virosomes obtainable thereby
EP3069729A1 (en) * 2015-03-17 2016-09-21 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
WO2016149417A1 (en) * 2015-03-17 2016-09-22 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
EP3849521A1 (en) 2018-09-14 2021-07-21 Massachusetts Institute Of Technology Nanoparticle vaccine adjuvant and methods of use thereof
CA3118692A1 (en) 2018-11-06 2020-05-14 Alsatech, Inc. Cell-based gene therapy for neurodegenerative diseases
US20220339282A1 (en) * 2018-11-29 2022-10-27 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
CA3161857A1 (en) 2019-11-22 2021-05-27 Glaxosmithkline Biologicals Sa Dosage and administration of a bacterial saccharide glycoconjugate vaccine
US20230190920A1 (en) 2021-12-19 2023-06-22 Massachusetts Institute Of Technology Compositions and methods for long-lasting germinal center responses to a priming immunization
WO2024064783A1 (en) 2022-09-21 2024-03-28 Wisconsin Alumni Research Foundation Compositions and methods to enhance therapeutic efficacy of cancer therapies
WO2024151642A1 (en) * 2023-01-09 2024-07-18 University Of Maryland, Baltimore Engineered anti-nociceptive-los competitive tlr4 ligands and methods for treating pain while maintaining immunosufficiency

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US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
CN1137799A (zh) * 1993-11-17 1996-12-11 实验室奥姆公司 葡糖胺二糖类、其制备方法和用途、以及含有这些二糖的药物组合物
US5654289A (en) * 1993-09-07 1997-08-05 Suntory Limited Disaccharide derivative
WO2001036433A2 (en) * 1999-11-15 2001-05-25 Biomira, Inc. Synthetic lipid-a analogs and uses thereof
CN1907289A (zh) * 2000-05-19 2007-02-07 科里克萨有限公司 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法
WO2009035528A2 (en) * 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
CN101627048A (zh) * 2006-11-16 2010-01-13 Om药物公司 功能性β-1，6葡糖胺二糖以及它们的制备方法

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GR860379B (en) * 1985-02-22 1986-06-11 Akzo Nv Novel disaccharide and trisaccharide derivatives of the lipid a type
JP2535048B2 (ja) 1988-02-29 1996-09-18 第一製薬株式会社 新規ジサッカライド誘導体及びその塩
JPH06206893A (ja) * 1992-09-07 1994-07-26 Suntory Ltd 新規なジサッカライド誘導体
JPH10152497A (ja) * 1996-09-30 1998-06-09 Otsuka Pharmaceut Factory Inc ヘリコバクター・ピロリのリピドａ
KR100682154B1 (ko) * 1998-05-07 2007-02-12 코릭사 코포레이션 아쥬번트 조성물 및 그의 사용방법
CA2333578C (en) * 1998-07-14 2010-11-16 American Cyanamid Company Adjuvant and vaccine compositions containing monophosphoryl lipid a
US20020022032A1 (en) * 1999-04-23 2002-02-21 Curry Patrick Mark Immuno-adjuvant PDT treatment of metastatic tumors
BR0110975A (pt) * 2000-05-19 2004-03-23 Corixa Corp Tratamento profilático e terapêutico de doenças infecciosas ou outras doenças com compostos à base de mono- e disacarìdeos
US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
GB0420634D0 (en) * 2004-09-16 2004-10-20 Glaxosmithkline Biolog Sa Vaccines
US7622128B2 (en) * 2005-12-13 2009-11-24 University Of Washington Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
PT2222710T (pt) * 2007-12-24 2016-11-02 Glaxosmithkline Biologicals Sa Antigénios de rsv recombinantes
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
US5654289A (en) * 1993-09-07 1997-08-05 Suntory Limited Disaccharide derivative
CN1137799A (zh) * 1993-11-17 1996-12-11 实验室奥姆公司 葡糖胺二糖类、其制备方法和用途、以及含有这些二糖的药物组合物
WO2001036433A2 (en) * 1999-11-15 2001-05-25 Biomira, Inc. Synthetic lipid-a analogs and uses thereof
CN1907289A (zh) * 2000-05-19 2007-02-07 科里克萨有限公司 用单糖和二糖类化合物预防和治疗传染病和其他疾病的方法
CN101627048A (zh) * 2006-11-16 2010-01-13 Om药物公司 功能性β-1，6葡糖胺二糖以及它们的制备方法
WO2009035528A2 (en) * 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative

Also Published As

Publication number Publication date
JP2018070652A (ja) 2018-05-10
JP6764396B2 (ja) 2020-09-30
CN104470938A (zh) 2015-03-25
DK3674309T3 (da) 2024-11-25
ES2992314T3 (es) 2024-12-11
CA2870008A1 (en) 2013-10-17
CN107412766A (zh) 2017-12-01
EP3674309B1 (en) 2024-09-11
EP2836499A4 (en) 2015-11-25
US20160136271A1 (en) 2016-05-19
WO2013155448A1 (en) 2013-10-17
EP2836499B1 (en) 2020-02-26
JP2015512946A (ja) 2015-04-30
CA2870008C (en) 2021-05-04
EP2836499A1 (en) 2015-02-18
JP2020147579A (ja) 2020-09-17
IN2014DN09392A (enExample) 2015-07-17
US20130273149A1 (en) 2013-10-17
JP7189906B2 (ja) 2022-12-14
ES2787876T3 (es) 2020-10-19
HK1207383A1 (en) 2016-01-29
JP6271510B2 (ja) 2018-01-31
US10143744B2 (en) 2018-12-04
US9241988B2 (en) 2016-01-26
EP3674309A1 (en) 2020-07-01

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