IN2014DN07636A - - Google Patents

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Publication number
IN2014DN07636A
IN2014DN07636A IN7636DEN2014A IN2014DN07636A IN 2014DN07636 A IN2014DN07636 A IN 2014DN07636A IN 7636DEN2014 A IN7636DEN2014 A IN 7636DEN2014A IN 2014DN07636 A IN2014DN07636 A IN 2014DN07636A
Authority
IN
India
Prior art keywords
compounds
liver
receptor
disease
compositions
Prior art date
Application number
Other languages
English (en)
Inventor
Chengguo Dong
Yi Fan
Katerina Leftheris
Stephen Lotesta
Suresh B Singh
Colin Tice
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of IN2014DN07636A publication Critical patent/IN2014DN07636A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
IN7636DEN2014 2012-03-16 2013-03-14 IN2014DN07636A (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612051P 2012-03-16 2012-03-16
PCT/US2013/031242 WO2013138565A1 (en) 2012-03-16 2013-03-14 Liver x receptor modulators

Publications (1)

Publication Number Publication Date
IN2014DN07636A true IN2014DN07636A (enExample) 2015-05-15

Family

ID=47997957

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7636DEN2014 IN2014DN07636A (enExample) 2012-03-16 2013-03-14

Country Status (27)

Country Link
US (4) US9006244B2 (enExample)
EP (1) EP2825541B1 (enExample)
JP (3) JP6114814B2 (enExample)
KR (1) KR102069912B1 (enExample)
CN (1) CN104203951B (enExample)
AU (1) AU2013232066B2 (enExample)
CA (1) CA2866218C (enExample)
CY (1) CY1118318T1 (enExample)
DK (1) DK2825541T3 (enExample)
EA (1) EA026907B1 (enExample)
ES (1) ES2598653T3 (enExample)
HR (1) HRP20161196T1 (enExample)
HU (1) HUE029402T2 (enExample)
IL (1) IL234265B (enExample)
IN (1) IN2014DN07636A (enExample)
LT (1) LT2825541T (enExample)
ME (1) ME02534B (enExample)
MX (1) MX354818B (enExample)
NZ (1) NZ629122A (enExample)
PL (1) PL2825541T3 (enExample)
PT (1) PT2825541T (enExample)
RS (1) RS55166B1 (enExample)
SG (1) SG11201405328SA (enExample)
SI (1) SI2825541T1 (enExample)
SM (1) SMT201600374B (enExample)
WO (1) WO2013138565A1 (enExample)
ZA (1) ZA201406326B (enExample)

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SG11201405328SA (en) * 2012-03-16 2014-11-27 Vitae Pharmaceuticals Inc Liver x receptor modulators
SMT201700009T1 (it) * 2012-03-16 2017-03-08 Vitae Pharmaceuticals Inc Modulatori del recettore x del fegato
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WO2015195922A1 (en) * 2014-06-19 2015-12-23 Vitae Pharmaceuticals, Inc. Compounds for use in treating acute coronary syndrome and related conditions
MX377304B (es) * 2014-08-07 2025-03-07 Vitae Pharmaceuticals Llc Derivados de piperazina como moduladores de los receptores x del hígado.
US20190125745A1 (en) * 2014-12-17 2019-05-02 Rgenix, Inc. Treatment and diagnosis of cancer
CN105017262B (zh) * 2015-07-07 2017-05-03 广东也乐新材料制造有限公司 一种醛基取代多环杂芳烃化合物的合成方法
CN105288658B (zh) * 2015-10-30 2018-08-28 中国人民解放军第三军医大学 miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用
US11648220B2 (en) 2016-01-11 2023-05-16 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
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EP4073025B1 (en) 2019-12-13 2024-03-27 Inspirna, Inc. Metal salts and uses thereof

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