ZA201406326B - Liver x receptor modulators - Google Patents

Liver x receptor modulators

Info

Publication number
ZA201406326B
ZA201406326B ZA201406326A ZA201406326A ZA201406326B ZA 201406326 B ZA201406326 B ZA 201406326B ZA 201406326 A ZA201406326 A ZA 201406326A ZA 201406326 A ZA201406326 A ZA 201406326A ZA 201406326 B ZA201406326 B ZA 201406326B
Authority
ZA
South Africa
Prior art keywords
liver
receptor modulators
modulators
receptor
Prior art date
Application number
ZA201406326A
Other languages
English (en)
Inventor
Chengguo Dong
Katerina Leftheris
Suresh B Signh
Wei Zhao
Linghang Zhuang
Yi Fan
Stephen Lotesta
Colin Tice
Yajun Zheng
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of ZA201406326B publication Critical patent/ZA201406326B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
ZA201406326A 2012-03-16 2014-08-27 Liver x receptor modulators ZA201406326B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612051P 2012-03-16 2012-03-16
PCT/US2013/031242 WO2013138565A1 (en) 2012-03-16 2013-03-14 Liver x receptor modulators

Publications (1)

Publication Number Publication Date
ZA201406326B true ZA201406326B (en) 2019-11-27

Family

ID=47997957

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA201406326A ZA201406326B (en) 2012-03-16 2014-08-27 Liver x receptor modulators

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US (4) US9006244B2 (enExample)
EP (1) EP2825541B1 (enExample)
JP (3) JP6114814B2 (enExample)
KR (1) KR102069912B1 (enExample)
CN (1) CN104203951B (enExample)
AU (1) AU2013232066B2 (enExample)
CA (1) CA2866218C (enExample)
CY (1) CY1118318T1 (enExample)
DK (1) DK2825541T3 (enExample)
EA (1) EA026907B1 (enExample)
ES (1) ES2598653T3 (enExample)
HR (1) HRP20161196T1 (enExample)
HU (1) HUE029402T2 (enExample)
IL (1) IL234265B (enExample)
IN (1) IN2014DN07636A (enExample)
LT (1) LT2825541T (enExample)
ME (1) ME02534B (enExample)
MX (1) MX354818B (enExample)
NZ (1) NZ629122A (enExample)
PL (1) PL2825541T3 (enExample)
PT (1) PT2825541T (enExample)
RS (1) RS55166B1 (enExample)
SG (1) SG11201405328SA (enExample)
SI (1) SI2825541T1 (enExample)
SM (1) SMT201600374B (enExample)
WO (1) WO2013138565A1 (enExample)
ZA (1) ZA201406326B (enExample)

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US20170231992A1 (en) * 2014-06-19 2017-08-17 Vitae Pharmaceuticals, Inc. Compounds for use in treating acute coronary syndrome and related conditions
EP3177617B1 (en) * 2014-08-07 2019-10-09 Vitae Pharmaceuticals, LLC Piperazine derivatives as liver x receptor modulators
WO2016100619A2 (en) * 2014-12-17 2016-06-23 Rgenix, Inc. Treatment and diagnosis of cancer
CN105017262B (zh) * 2015-07-07 2017-05-03 广东也乐新材料制造有限公司 一种醛基取代多环杂芳烃化合物的合成方法
CN105288658B (zh) * 2015-10-30 2018-08-28 中国人民解放军第三军医大学 miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用
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