HRP20161196T1 - Modulatori jetrenog receptora x - Google Patents

Modulatori jetrenog receptora x Download PDF

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Publication number
HRP20161196T1
HRP20161196T1 HRP20161196TT HRP20161196T HRP20161196T1 HR P20161196 T1 HRP20161196 T1 HR P20161196T1 HR P20161196T T HRP20161196T T HR P20161196TT HR P20161196 T HRP20161196 T HR P20161196T HR P20161196 T1 HRP20161196 T1 HR P20161196T1
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HR
Croatia
Prior art keywords
alkyl
nrc
halogen
haloalkyl
compound according
Prior art date
Application number
HRP20161196TT
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English (en)
Croatian (hr)
Inventor
Chengguo DONG
Yi Fan
Katerina Leftheris
Stephen LOTESTA
Suresh B. Singh
Colin Tice
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Vitae Pharmaceuticals, Inc. filed Critical Vitae Pharmaceuticals, Inc.
Publication of HRP20161196T1 publication Critical patent/HRP20161196T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
HRP20161196TT 2012-03-16 2013-03-14 Modulatori jetrenog receptora x HRP20161196T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612051P 2012-03-16 2012-03-16
PCT/US2013/031242 WO2013138565A1 (en) 2012-03-16 2013-03-14 Liver x receptor modulators
EP13712102.6A EP2825541B1 (en) 2012-03-16 2013-03-14 Liver x receptor modulators

Publications (1)

Publication Number Publication Date
HRP20161196T1 true HRP20161196T1 (hr) 2016-11-04

Family

ID=47997957

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161196TT HRP20161196T1 (hr) 2012-03-16 2013-03-14 Modulatori jetrenog receptora x

Country Status (27)

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US (4) US9006244B2 (enExample)
EP (1) EP2825541B1 (enExample)
JP (3) JP6114814B2 (enExample)
KR (1) KR102069912B1 (enExample)
CN (1) CN104203951B (enExample)
AU (1) AU2013232066B2 (enExample)
CA (1) CA2866218C (enExample)
CY (1) CY1118318T1 (enExample)
DK (1) DK2825541T3 (enExample)
EA (1) EA026907B1 (enExample)
ES (1) ES2598653T3 (enExample)
HR (1) HRP20161196T1 (enExample)
HU (1) HUE029402T2 (enExample)
IL (1) IL234265B (enExample)
IN (1) IN2014DN07636A (enExample)
LT (1) LT2825541T (enExample)
ME (1) ME02534B (enExample)
MX (1) MX354818B (enExample)
NZ (1) NZ629122A (enExample)
PL (1) PL2825541T3 (enExample)
PT (1) PT2825541T (enExample)
RS (1) RS55166B1 (enExample)
SG (1) SG11201405328SA (enExample)
SI (1) SI2825541T1 (enExample)
SM (1) SMT201600374B (enExample)
WO (1) WO2013138565A1 (enExample)
ZA (1) ZA201406326B (enExample)

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ME02660B (me) 2012-03-16 2017-06-20 Vitae Pharmaceuticals Inc Modulator! jetrenog x receptora
CN104203951B (zh) * 2012-03-16 2016-11-02 生命医药公司 肝x受体调节剂
US10669296B2 (en) 2014-01-10 2020-06-02 Rgenix, Inc. LXR agonists and uses thereof
US20170231992A1 (en) * 2014-06-19 2017-08-17 Vitae Pharmaceuticals, Inc. Compounds for use in treating acute coronary syndrome and related conditions
EP3177617B1 (en) * 2014-08-07 2019-10-09 Vitae Pharmaceuticals, LLC Piperazine derivatives as liver x receptor modulators
WO2016100619A2 (en) * 2014-12-17 2016-06-23 Rgenix, Inc. Treatment and diagnosis of cancer
CN105017262B (zh) * 2015-07-07 2017-05-03 广东也乐新材料制造有限公司 一种醛基取代多环杂芳烃化合物的合成方法
CN105288658B (zh) * 2015-10-30 2018-08-28 中国人民解放军第三军医大学 miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用
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WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
PL4073025T3 (pl) 2019-12-13 2024-09-16 Inspirna, Inc. Sole metali i ich zastosowania

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