IN2013MN01164A - - Google Patents

Info

Publication number
IN2013MN01164A
IN2013MN01164A IN1164MUN2013A IN2013MN01164A IN 2013MN01164 A IN2013MN01164 A IN 2013MN01164A IN 1164MUN2013 A IN1164MUN2013 A IN 1164MUN2013A IN 2013MN01164 A IN2013MN01164 A IN 2013MN01164A
Authority
IN
India
Prior art keywords
compounds
salts
formula
methods
pharmaceutical formulations
Prior art date
Application number
Other languages
English (en)
Inventor
Jean Marie Defauw
Scott Dale Holmstrom
Shuhui Chen
Yang Zhang
Wentao Wu
Xian Peng
Yujuan Ma
Lun Lu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN2013MN01164A publication Critical patent/IN2013MN01164A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/20All rings being cycloaliphatic the ring system containing seven carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/50Spiro compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN1164MUN2013 2011-01-27 2012-01-13 IN2013MN01164A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2011/070706 WO2012100423A1 (fr) 2011-01-27 2011-01-27 Composés analgésiques, procédés, et formulations
PCT/US2012/021181 WO2012102875A2 (fr) 2011-01-27 2012-01-13 Composés analgésiques, procédés, et formulations

Publications (1)

Publication Number Publication Date
IN2013MN01164A true IN2013MN01164A (fr) 2015-04-17

Family

ID=45558412

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1164MUN2013 IN2013MN01164A (fr) 2011-01-27 2012-01-13

Country Status (22)

Country Link
US (1) US8802728B2 (fr)
EP (1) EP2668152B1 (fr)
JP (1) JP6002153B2 (fr)
KR (1) KR101612168B1 (fr)
CN (2) CN103328433B (fr)
AR (2) AR084815A1 (fr)
AU (1) AU2012209430B2 (fr)
BR (1) BR112013018527B1 (fr)
CA (1) CA2825816C (fr)
CL (1) CL2013002102A1 (fr)
CO (1) CO6781505A2 (fr)
EA (1) EA024101B1 (fr)
ES (1) ES2612495T3 (fr)
IL (1) IL227250A (fr)
IN (1) IN2013MN01164A (fr)
MX (1) MX345518B (fr)
MY (1) MY163262A (fr)
SG (1) SG192131A1 (fr)
TW (1) TWI564275B (fr)
UA (1) UA110122C2 (fr)
WO (2) WO2012100423A1 (fr)
ZA (1) ZA201304786B (fr)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19805370A1 (de) * 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
US6780891B2 (en) * 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
US20050182131A1 (en) 2002-07-19 2005-08-18 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence
DE10233048A1 (de) * 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
EP2022778A1 (fr) * 2007-08-07 2009-02-11 Laboratorios del Dr. Esteve S.A. Forme cristalline du sel de (R,R)-tramadol-(S)-naproxène

Also Published As

Publication number Publication date
AR126189A2 (es) 2023-09-27
JP6002153B2 (ja) 2016-10-05
IL227250A (en) 2015-03-31
AU2012209430B2 (en) 2014-11-13
CN105753723B (zh) 2018-11-06
JP2014511368A (ja) 2014-05-15
EA024101B1 (ru) 2016-08-31
ES2612495T3 (es) 2017-05-17
CO6781505A2 (es) 2013-10-31
BR112013018527B1 (pt) 2021-11-09
TWI564275B (zh) 2017-01-01
WO2012102875A3 (fr) 2012-10-18
KR101612168B1 (ko) 2016-04-12
MX345518B (es) 2017-02-02
MY163262A (en) 2017-08-30
MX2013008708A (es) 2014-01-23
NZ612731A (en) 2015-04-24
KR20130116348A (ko) 2013-10-23
WO2012102875A2 (fr) 2012-08-02
AR084815A1 (es) 2013-06-26
CN103328433A (zh) 2013-09-25
CL2013002102A1 (es) 2014-06-27
ZA201304786B (en) 2014-12-23
CN105753723A (zh) 2016-07-13
US8802728B2 (en) 2014-08-12
US20130225679A1 (en) 2013-08-29
CA2825816A1 (fr) 2012-08-02
CN103328433B (zh) 2016-06-08
CA2825816C (fr) 2016-08-09
UA110122C2 (uk) 2015-11-25
WO2012100423A1 (fr) 2012-08-02
EA201390857A1 (ru) 2014-01-30
BR112013018527A2 (pt) 2016-10-18
AU2012209430A1 (en) 2013-07-04
EP2668152A2 (fr) 2013-12-04
EP2668152B1 (fr) 2016-10-12
SG192131A1 (en) 2013-08-30
TW201242930A (en) 2012-11-01

Similar Documents

Publication Publication Date Title
IN2014MN02598A (fr)
MX2016006336A (es) Compuestos pirazolopirimidina.
NZ709211A (en) Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
RS54873B1 (sr) Policiklična-karbamoilpiridonska jedinjenja i njihova farmaceutska upotreba
PH12014502733A1 (en) Neprilysin inhibitors
PH12015501993B1 (en) Pyrazole-amide compound and medicinal uses therefor
MY163083A (en) Solid forms of a pharmaceutically active substance
PH12015500260A1 (en) Neprilysin inhibitors
AU2012214029A8 (en) Rorgammat inhibitors
IN2015DN01119A (fr)
MY172422A (en) Pyrazole compound and pharmaceutical use thereof
BR112015004499A2 (pt) métodos de administração de terapia de pirfenidona
WO2012135615A3 (fr) Enopeptines, utilisations de celles-ci, et procédés de synthèse de celles-ci
MX364400B (es) Compuestos de tetraciclina.
IN2014DN06192A (fr)
JO2930B1 (en) A new process for the synthesis of ivabradine and salts of addition with a pharmaceutically acceptable acid
EA201100230A1 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
UA118008C2 (uk) Спосіб синтезу (2е)-3-(3,4-диметоксифеніл)проп-2-еннітрилу та застосування в синтезі івабрадину та його адитивних солей з фармацевтично прийнятною кислотою
EA201500313A1 (ru) Стабилизированная аморфная форма агомелатина, способ ее изготовления и фармацевтические композиции, ее содержащие
EA201201385A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201301235A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
IN2013MN01164A (fr)
EA201301020A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201300281A2 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
EA201201571A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей