IN2013MN00733A - - Google Patents

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Publication number
IN2013MN00733A
IN2013MN00733A IN733MUN2013A IN2013MN00733A IN 2013MN00733 A IN2013MN00733 A IN 2013MN00733A IN 733MUN2013 A IN733MUN2013 A IN 733MUN2013A IN 2013MN00733 A IN2013MN00733 A IN 2013MN00733A
Authority
IN
India
Prior art keywords
disclosed
lubiprostone
intermediates
purifying
preparing
Prior art date
Application number
Other languages
English (en)
Inventor
Julian P Henschke
Yuanlian Liu
Lizhen Xia
Yung Fa Chen
Original Assignee
Scinopharm Kunshan Biochemical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Kunshan Biochemical Technology Co Ltd filed Critical Scinopharm Kunshan Biochemical Technology Co Ltd
Publication of IN2013MN00733A publication Critical patent/IN2013MN00733A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/42Halogenated unsaturated alcohols acyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/215Saturated compounds having only one carboxyl group and containing keto groups containing singly bound oxygen containing groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P31/00Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/01Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003Triacylglycerol lipase (3.1.1.3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
IN733MUN2013 2010-10-15 2010-10-15 IN2013MN00733A (en(2012))

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2010/001614 WO2012048447A1 (en) 2010-10-15 2010-10-15 Processes for preparation of lubiprostone

Publications (1)

Publication Number Publication Date
IN2013MN00733A true IN2013MN00733A (en(2012)) 2015-06-12

Family

ID=45937817

Family Applications (1)

Application Number Title Priority Date Filing Date
IN733MUN2013 IN2013MN00733A (en(2012)) 2010-10-15 2010-10-15

Country Status (14)

Country Link
US (2) US8846958B2 (en(2012))
EP (1) EP2627647B1 (en(2012))
JP (1) JP5755750B2 (en(2012))
KR (1) KR101787159B1 (en(2012))
CN (1) CN103180306B (en(2012))
AU (1) AU2010362494B2 (en(2012))
BR (1) BR112013009163A2 (en(2012))
CA (1) CA2813839C (en(2012))
ES (1) ES2616023T3 (en(2012))
IL (1) IL225754A (en(2012))
IN (1) IN2013MN00733A (en(2012))
NZ (1) NZ608823A (en(2012))
TW (1) TWI434837B (en(2012))
WO (1) WO2012048447A1 (en(2012))

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140043075A (ko) * 2011-04-19 2014-04-08 수캄포 아게 사이토카인 활성의 조절 방법
JP6079128B2 (ja) * 2012-10-23 2017-02-15 Jsr株式会社 フォトレジスト組成物及びレジストパターン形成方法
KR102311896B1 (ko) * 2013-09-30 2021-10-14 패턴 에이피아이 서비시즈 인코포레이티드 복분해를 사용하는 프로스타글란딘 및 프로스타글란딘 중간체의 합성 경로
CN105254657B (zh) * 2014-07-10 2018-06-15 台湾神隆股份有限公司 金属催化不对称1,4-共轭加成反应产生前列腺素和前列腺素类似物
CN104710398A (zh) * 2015-02-17 2015-06-17 齐鲁制药有限公司 鲁比前列酮的新晶型及其制备方法
KR102636648B1 (ko) * 2016-09-13 2024-02-15 삼성전자주식회사 플렉서블 디스플레이 전자 장치
US10253011B1 (en) * 2018-07-13 2019-04-09 Chirogate International Inc. Lubiprostone crystals and methods for preparing the same
US10457623B1 (en) 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001179A1 (en) * 1993-06-29 1995-01-12 Brigham & Women's Hospital Modulation of inflammation related to columnar epithelia
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
CA2595898C (en) * 2005-01-27 2015-04-28 Sucampo Ag Method and composition for treating central nervous system disorders
PT1853271E (pt) * 2005-03-04 2011-01-28 Sucampo Ag Método e composição para o tratamento de doenças vasculares periféricas
JP4648340B2 (ja) * 2006-02-07 2011-03-09 株式会社アールテック・ウエノ 15−ケトプロスタグランジンe誘導体の製造法
AR071312A1 (es) 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd Proceso para la preparacion de analogos de prostaglandina y sus intermediarios
US8513441B2 (en) * 2008-08-29 2013-08-20 Alphora Research Inc. Prostaglandin synthesis and intermediates for use therein
JP5231266B2 (ja) 2009-01-19 2013-07-10 Ntn株式会社 等速自在継手の外方部材
CA2750487A1 (en) * 2009-01-22 2010-07-29 Apotex Pharmachem Inc. Methods of making lubiprostone and intermediates thereof
CA2784933A1 (en) * 2009-12-18 2011-06-23 Apotex Pharmachem Inc. Processes for the purification of lubiprostone

Also Published As

Publication number Publication date
TWI434837B (zh) 2014-04-21
US20150005528A1 (en) 2015-01-01
TW201300370A (zh) 2013-01-01
US8846958B2 (en) 2014-09-30
US20130225842A1 (en) 2013-08-29
BR112013009163A2 (pt) 2016-07-26
NZ608823A (en) 2014-11-28
CA2813839A1 (en) 2012-04-19
CA2813839C (en) 2017-03-21
CN103180306B (zh) 2015-05-20
EP2627647A1 (en) 2013-08-21
JP5755750B2 (ja) 2015-07-29
AU2010362494B2 (en) 2015-01-15
WO2012048447A1 (en) 2012-04-19
IL225754A0 (en) 2013-06-27
AU2010362494A1 (en) 2013-04-18
IL225754A (en) 2017-04-30
KR20140027905A (ko) 2014-03-07
JP2014501698A (ja) 2014-01-23
ES2616023T3 (es) 2017-06-09
CN103180306A (zh) 2013-06-26
EP2627647B1 (en) 2016-12-14
KR101787159B1 (ko) 2017-10-18
EP2627647A4 (en) 2015-07-29
US9012662B2 (en) 2015-04-21

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