IN2012DN02073A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02073A
IN2012DN02073A IN2073DEN2012A IN2012DN02073A IN 2012DN02073 A IN2012DN02073 A IN 2012DN02073A IN 2073DEN2012 A IN2073DEN2012 A IN 2073DEN2012A IN 2012DN02073 A IN2012DN02073 A IN 2012DN02073A
Authority
IN
India
Prior art keywords
hcg
including recombinant
preparations including
preparations
recombinant hcg
Prior art date
Application number
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of IN2012DN02073A publication Critical patent/IN2012DN02073A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN2073DEN2012 2009-10-05 2010-10-04 IN2012DN02073A (enrdf_load_stackoverflow)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09252360 2009-10-05
PCT/GB2010/001854 WO2011042688A1 (en) 2009-10-05 2010-10-04 Pharmaceutical preparation comprising recombinant hcg

Publications (1)

Publication Number Publication Date
IN2012DN02073A true IN2012DN02073A (enrdf_load_stackoverflow) 2015-08-21

Family

ID=41471027

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2073DEN2012 IN2012DN02073A (enrdf_load_stackoverflow) 2009-10-05 2010-10-04

Country Status (25)

Country Link
US (5) US8975226B2 (enrdf_load_stackoverflow)
EP (2) EP2486051B1 (enrdf_load_stackoverflow)
JP (6) JP6176924B2 (enrdf_load_stackoverflow)
KR (7) KR20210014767A (enrdf_load_stackoverflow)
CN (1) CN107050434B (enrdf_load_stackoverflow)
AR (2) AR079876A1 (enrdf_load_stackoverflow)
AU (1) AU2010304922B2 (enrdf_load_stackoverflow)
BR (1) BR112012007990A2 (enrdf_load_stackoverflow)
CA (1) CA2776790A1 (enrdf_load_stackoverflow)
DK (1) DK2486051T3 (enrdf_load_stackoverflow)
ES (1) ES2798258T3 (enrdf_load_stackoverflow)
HR (1) HRP20200941T1 (enrdf_load_stackoverflow)
HU (1) HUE050793T2 (enrdf_load_stackoverflow)
IL (3) IL218548A (enrdf_load_stackoverflow)
IN (1) IN2012DN02073A (enrdf_load_stackoverflow)
JO (1) JOP20200039A1 (enrdf_load_stackoverflow)
LT (1) LT2486051T (enrdf_load_stackoverflow)
MX (1) MX2012003951A (enrdf_load_stackoverflow)
PL (1) PL2486051T3 (enrdf_load_stackoverflow)
PT (1) PT2486051T (enrdf_load_stackoverflow)
RS (1) RS60413B1 (enrdf_load_stackoverflow)
RU (2) RU2724528C2 (enrdf_load_stackoverflow)
SI (1) SI2486051T1 (enrdf_load_stackoverflow)
TW (2) TWI532495B (enrdf_load_stackoverflow)
WO (1) WO2011042688A1 (enrdf_load_stackoverflow)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
CA2831486A1 (en) * 2011-03-31 2012-10-04 Ferring B.V. Pharmaceutical preparation
EP2717904A1 (en) * 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
CN104919046A (zh) 2012-12-10 2015-09-16 生化学工业株式会社 新重组因子c、其制造方法、及内毒素的测定法
CN107429237B (zh) * 2014-12-22 2021-09-28 豪夫迈·罗氏有限公司 Cmp依赖性的唾液酸酶活性
TN2017000328A1 (en) * 2015-04-24 2019-01-16 Ferring Bv Method of production of gonadotrophin
JP6845813B2 (ja) 2015-06-26 2021-03-24 フェリング ベスローテン フェンノートシャップ 精製および/またはウイルス不活性化の方法
ES3029733T3 (en) * 2018-04-30 2025-06-25 Ferring Bv Composition for controlled ovarian stimulation
KR20220137651A (ko) * 2020-02-05 2022-10-12 노파르티스 아게 Il-15 이종이량체를 발현하는 cho 세포
CN116199742B (zh) * 2022-07-06 2025-01-24 华兰基因工程有限公司 一种重组人绒毛膜促性腺激素Fc融合蛋白制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
DK49987A (da) * 1987-01-30 1988-07-31 Nordisk Gentofte Fremgangsmaade til behandling af infertilitet og middel til anvendelse ved fremgangsmaaden
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
DE69524456T2 (de) * 1995-03-21 2002-08-01 Applied Research Systems Flüssige hcg-formulierungen
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
KR100560279B1 (ko) 1997-06-25 2006-03-10 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 이황화결합으로 연결된 당단백질 호르몬 유사체, 이의제조방법 및 이의 용도
US6500627B1 (en) 1998-02-03 2002-12-31 The Trustees Of Columbia University In The City Of New York Methods for predicting pregnancy outcome in a subject by HCG assay
WO2003050286A1 (en) * 2001-10-29 2003-06-19 Crucell Holland B.V. Methods and means for producing proteins with predetermined post-translational modifications
CN1352566A (zh) 1999-05-07 2002-06-05 应用研究系统Ars股份公司 促性腺激素
EA006605B1 (ru) * 2000-02-22 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
EP1425032A2 (en) 2001-09-12 2004-06-09 Applied Research Systems ARS Holding N.V. USE OF hCG IN CONTROLLED OVARIAN HYPERSTIMULATION
RS32804A (en) 2001-10-22 2007-02-05 Applied Research Systems Ars Holding N.V., Gonadotrophins for folliculogenesis
DK1440157T3 (da) * 2001-10-29 2012-05-07 Crucell Holland Bv Methods and means for producing proteins with predetermined post-translational modifications
CN1374525A (zh) * 2001-12-31 2002-10-16 陕西超英生物医学研究开发有限公司 一种抗体芯片、其制备技术及其检测方法
CA2517487A1 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
SG155777A1 (en) * 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
US20040248784A1 (en) 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
JP4518464B2 (ja) 2003-06-30 2010-08-04 ミヨシ油脂株式会社 紙類処理剤及び紙類
ES2425475T3 (es) * 2003-08-18 2013-10-15 Glycotope Gmbh Líneas de células tumorales NM-F9 (DSM ACC2606) y NM-D4 (DSM ACC2605), usos de las mismas
ATE476666T1 (de) * 2004-02-04 2010-08-15 Centre Nat Rech Scient Verfahren zur identifizierung von glykoformspezifischen antikörpern
WO2005080585A1 (en) * 2004-02-13 2005-09-01 Glycotope Gmbh Highly active glycoproteins-process conditions and an efficient method for their production
CN101137396A (zh) * 2005-03-11 2008-03-05 弗雷泽纽斯卡比德国有限公司 由无活性初始材料制备生物活性糖蛋白
DE112006002122B4 (de) 2005-08-15 2016-09-22 Continental Automotive Systems, Inc. ( n. d. Ges. d. Staates Delaware ) Dieselabgas-Kohlenwasserstoff-Dosierventil für Fahrzeuge
RU2309411C2 (ru) * 2005-11-24 2007-10-27 Ростовский НИИ акушерства и педиатрии МЗ РФ Способ отбора пациенток с синдромом "пустых" фолликулов для проведения программы эко и пэ донорскими ооцитами
KR100809945B1 (ko) * 2006-02-01 2008-03-05 대한민국 인체장내정상세균총 특이반응 dna칩 및 이를 이용한인체장내정상세균총의 변화에 의한 인체 위해성의 평가방법
US20080242607A1 (en) * 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) * 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
TWI488640B (zh) * 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
CA2831486A1 (en) * 2011-03-31 2012-10-04 Ferring B.V. Pharmaceutical preparation
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض

Also Published As

Publication number Publication date
AU2010304922B2 (en) 2014-11-06
KR20190067256A (ko) 2019-06-14
KR101804479B1 (ko) 2017-12-05
JP6310440B2 (ja) 2018-04-11
LT2486051T (lt) 2020-07-10
JP7196244B2 (ja) 2022-12-26
US20130023476A1 (en) 2013-01-24
EP2486051A1 (en) 2012-08-15
US11292824B2 (en) 2022-04-05
RS60413B1 (sr) 2020-07-31
SI2486051T1 (sl) 2020-08-31
ES2798258T3 (es) 2020-12-10
WO2011042688A1 (en) 2011-04-14
CN102549011A (zh) 2012-07-04
JP2018076296A (ja) 2018-05-17
RU2012112907A (ru) 2013-11-10
JP7292153B2 (ja) 2023-06-16
RU2016118236A3 (enrdf_load_stackoverflow) 2019-09-18
PL2486051T3 (pl) 2020-09-07
PT2486051T (pt) 2020-06-17
US20200247863A1 (en) 2020-08-06
KR102489143B1 (ko) 2023-01-13
RU2016118236A (ru) 2018-10-29
US20220340634A1 (en) 2022-10-27
KR102213154B1 (ko) 2021-02-05
DK2486051T3 (da) 2020-06-22
JOP20200039A1 (ar) 2022-10-30
HRP20200941T1 (hr) 2020-09-18
BR112012007990A2 (pt) 2017-07-25
KR20210014767A (ko) 2021-02-09
IL250733A0 (en) 2017-04-30
JP6580104B2 (ja) 2019-09-25
US20140249082A1 (en) 2014-09-04
IL267556A (en) 2019-08-29
TW201113030A (en) 2011-04-16
MX2012003951A (es) 2012-05-29
IL218548A (en) 2017-03-30
TW201632198A (zh) 2016-09-16
JP6176924B2 (ja) 2017-08-09
JP2020000246A (ja) 2020-01-09
JP2023075144A (ja) 2023-05-30
JP2013506708A (ja) 2013-02-28
AR079876A1 (es) 2012-02-29
KR20120094909A (ko) 2012-08-27
TWI604850B (zh) 2017-11-11
RU2588650C2 (ru) 2016-07-10
US10526390B2 (en) 2020-01-07
KR20170133531A (ko) 2017-12-05
HUE050793T2 (hu) 2021-01-28
EP2486051B1 (en) 2020-03-25
KR20210141771A (ko) 2021-11-23
KR20190028823A (ko) 2019-03-19
IL250733B (en) 2019-07-31
EP3611185B1 (en) 2025-04-30
CN107050434A (zh) 2017-08-18
TWI532495B (zh) 2016-05-11
JP2016074680A (ja) 2016-05-12
CA2776790A1 (en) 2011-04-14
EP3611185A1 (en) 2020-02-19
CN107050434B (zh) 2021-07-27
AU2010304922A1 (en) 2012-03-29
US8975226B2 (en) 2015-03-10
KR101987982B1 (ko) 2019-06-11
US9676835B2 (en) 2017-06-13
US20180030107A1 (en) 2018-02-01
RU2724528C2 (ru) 2020-06-23
AR125991A2 (es) 2023-08-30
US12234272B2 (en) 2025-02-25
JP2021176867A (ja) 2021-11-11
KR20230012104A (ko) 2023-01-25
IL218548A0 (en) 2012-05-31

Similar Documents

Publication Publication Date Title
IN2012DN02073A (enrdf_load_stackoverflow)
EP4302783A3 (en) Modified relaxin polypeptides and their uses
IN2011KN03851A (enrdf_load_stackoverflow)
IN2012DN06714A (enrdf_load_stackoverflow)
UA103774C2 (uk) Модифіковані поліпептиди бичачого гранулоцитарного колонієстимулювального фактора (g-csf) та їх застосування
AU334234S (en) Clamp for fence panels
JO3755B1 (ar) تركيبات تستوستيرون
MX2012006981A (es) Polipeptidos de somatotropina bovina modificados y sus usos.
MX2012006980A (es) Polipeptidos de somatotropina porcina modificados y sus usos.
MY168248A (en) Next-instruction-type field
AU2011347268A8 (en) Recombinant Mycobacterium as a vaccine
IN2011KN03928A (enrdf_load_stackoverflow)
IN2012DN04412A (enrdf_load_stackoverflow)
JO3497B1 (ar) مستحضر صيدلي يشتمل على hcg مأشوب
GB2491544A (en) Perpetum mobile
IN2012DN04805A (enrdf_load_stackoverflow)
UA42262U (en) 3-METHYL-7-β-HYDROXY-γ-(N-CHLOROPHENOXY)PROPYL-8-METHYLTHIOXANTINE EXHIBITING DIURETIC ACTION
AU313101S (en) Glass balustrading clamp - Frameless
UA35660U (en) Use of antihomotoxic preparations as cytoprotectors
CL2009001949S1 (es) Cajero automatico.
AU333244S (en) Control panel
AU325379S (en) Scarves
UA34276U (ru) 7-β-ГИДРОКСИЭТИЛ-3-МЕТИЛ-8-N-ПИРРОЛИДИНОКСАНТИН, КОТОРЫЙ ПРОЯВЛЯЕТ ДИУРЕТИЧЕСКОЕ ДЕЙСТВИЕ
CL2009001549S1 (es) Sillon.
CL2009001548S1 (es) Sillon.