IL98860A - Polycyclic quinuclidine amine derivatives and pharmaceutical compositions containing them - Google Patents

Polycyclic quinuclidine amine derivatives and pharmaceutical compositions containing them

Info

Publication number
IL98860A
IL98860A IL9886091A IL9886091A IL98860A IL 98860 A IL98860 A IL 98860A IL 9886091 A IL9886091 A IL 9886091A IL 9886091 A IL9886091 A IL 9886091A IL 98860 A IL98860 A IL 98860A
Authority
IL
Israel
Prior art keywords
compound
amine
azatricyclo
methyl
diphenylmethyl
Prior art date
Application number
IL9886091A
Other languages
English (en)
Other versions
IL98860A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL98860A0 publication Critical patent/IL98860A0/xx
Publication of IL98860A publication Critical patent/IL98860A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Control Of Electric Motors In General (AREA)
  • Soft Magnetic Materials (AREA)
  • Paper (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9886091A 1990-07-23 1991-07-15 Polycyclic quinuclidine amine derivatives and pharmaceutical compositions containing them IL98860A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55744290A 1990-07-23 1990-07-23

Publications (2)

Publication Number Publication Date
IL98860A0 IL98860A0 (en) 1992-07-15
IL98860A true IL98860A (en) 1995-11-27

Family

ID=24225412

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9886091A IL98860A (en) 1990-07-23 1991-07-15 Polycyclic quinuclidine amine derivatives and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (5) US5422354A (de)
EP (1) EP0540526B1 (de)
JP (1) JP2514137B2 (de)
CN (1) CN1058405A (de)
AT (1) ATE116317T1 (de)
AU (1) AU660416B2 (de)
BR (1) BR9106665A (de)
CA (1) CA2086434C (de)
DE (1) DE69106365T2 (de)
DK (1) DK0540526T3 (de)
ES (1) ES2065691T3 (de)
FI (1) FI114473B (de)
GR (1) GR3015144T3 (de)
HU (1) HUT62584A (de)
IE (1) IE65000B1 (de)
IL (1) IL98860A (de)
MX (1) MX9100308A (de)
MY (1) MY107157A (de)
NO (1) NO302172B1 (de)
NZ (1) NZ239063A (de)
PL (1) PL167568B1 (de)
PT (1) PT98393B (de)
WO (1) WO1992001688A1 (de)
YU (1) YU128091A (de)
ZA (1) ZA915727B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
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ATE142199T1 (de) * 1991-06-20 1996-09-15 Pfizer Fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen
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HUT70741A (en) * 1991-11-12 1995-10-30 Pfizer Acyclic ethylenediamine derivatives as substance p receptor antagonists
ES2164657T3 (es) * 1992-05-18 2002-03-01 Pfizer Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
US5688804A (en) * 1992-08-04 1997-11-18 Pfizer Inc. 3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists
PT655996E (pt) * 1992-08-19 2002-04-29 Pfizer Benzilaminas substituidas contendo heterociclicos nao aromaticos contendo azoto
CA2150123C (en) * 1992-12-10 2004-12-07 Harry R. Howard Aminomethylene substituted non-aromatic heterocycles
US5830854A (en) * 1992-12-14 1998-11-03 Merck Sharp & Dohme, Limited Method of treating cystic fibrosis using a tachykinin receptor antagonist
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0655246A1 (de) * 1993-11-30 1995-05-31 Pfizer Inc. Substanz P Antagonisten zur Behandlung von durch Helicobacter Pylori oder andere spirale Urease-positive Gram-negative Bakterien verursachten Krankheiten
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
GB9502582D0 (en) * 1995-02-10 1995-03-29 Smithkline Beecham Plc Novel process
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
EP0901490B1 (de) * 1996-05-13 2004-04-07 Syngenta Limited Bicyclische amine als insektizide
AU3784997A (en) 1996-08-09 1998-03-06 Eisai Co. Ltd. Benzopiperidine derivatives
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
TR199901704T2 (xx) 1996-11-26 1999-12-21 Zeneca Limited 8-Azabisiklo$3.2.1]oktan-, 8-azabisiklo$3.2.1]okt-6-en-,9-azabisiklo$3.3.1] nonan-,9-aza-3-oksabisiklo$3.3.1]nonan-ve 9-aza-3-tiabisiklo$3.3.1]nonan t�revleri, bunlar�n haz�rlanmas� ve insektisidler olarak kullan�mlar�.
JP2003513020A (ja) * 1999-09-27 2003-04-08 ジョージタウン ユニバーシティー 新規なトロパン類似体
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KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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GB1527489A (en) * 1976-08-05 1978-10-04 Andreu Sa Dr Amine compound
US4246201A (en) * 1979-06-11 1981-01-20 Alfa Farmaceutici, S.P.A. Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
WO1991009844A1 (en) * 1990-01-04 1991-07-11 Pfizer Inc. Substance p antagonists
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DK0540526T3 (da) * 1990-07-23 1995-04-18 Pfizer Quinuclidinderivater

Also Published As

Publication number Publication date
US5821248A (en) 1998-10-13
CA2086434A1 (en) 1992-01-24
ES2065691T3 (es) 1995-02-16
AU7894891A (en) 1992-02-18
HU9300188D0 (en) 1993-04-28
PL167568B1 (pl) 1995-09-30
CN1058405A (zh) 1992-02-05
CA2086434C (en) 1998-09-22
NO930222L (no) 1993-01-22
FI930262A0 (fi) 1993-01-22
ZA915727B (en) 1993-02-24
ATE116317T1 (de) 1995-01-15
JP2514137B2 (ja) 1996-07-10
EP0540526B1 (de) 1994-12-28
DE69106365D1 (de) 1995-02-09
IE65000B1 (en) 1995-10-04
EP0540526A1 (de) 1993-05-12
DK0540526T3 (da) 1995-04-18
BR9106665A (pt) 1993-06-08
MY107157A (en) 1995-09-30
GR3015144T3 (en) 1995-05-31
JPH05507687A (ja) 1993-11-04
NO930222D0 (no) 1993-01-22
YU128091A (sh) 1994-01-20
FI930262A (fi) 1993-01-22
NO302172B1 (no) 1998-02-02
US5854256A (en) 1998-12-29
US5698568A (en) 1997-12-16
HUT62584A (en) 1993-05-28
US5422354A (en) 1995-06-06
US5641786A (en) 1997-06-24
FI114473B (fi) 2004-10-29
IL98860A0 (en) 1992-07-15
AU660416B2 (en) 1995-06-29
NZ239063A (en) 1995-09-26
IE912560A1 (en) 1992-01-29
PT98393B (pt) 1999-01-29
PT98393A (pt) 1992-05-29
MX9100308A (es) 1992-02-28
DE69106365T2 (de) 1995-05-04
WO1992001688A1 (en) 1992-02-06

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