IL98472A - Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and their pharmaceutical use - Google Patents

Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and their pharmaceutical use

Info

Publication number
IL98472A
IL98472A IL9847291A IL9847291A IL98472A IL 98472 A IL98472 A IL 98472A IL 9847291 A IL9847291 A IL 9847291A IL 9847291 A IL9847291 A IL 9847291A IL 98472 A IL98472 A IL 98472A
Authority
IL
Israel
Prior art keywords
methyl
compound
mmol
compounds
preparation
Prior art date
Application number
IL9847291A
Other languages
English (en)
Other versions
IL98472A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9002206A external-priority patent/SE9002206D0/xx
Priority claimed from SE9002207A external-priority patent/SE9002207D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL98472A0 publication Critical patent/IL98472A0/xx
Publication of IL98472A publication Critical patent/IL98472A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL9847291A 1990-06-20 1991-06-12 Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and their pharmaceutical use IL98472A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds
SE9002207A SE9002207D0 (sv) 1990-06-20 1990-06-20 New compounds i

Publications (2)

Publication Number Publication Date
IL98472A0 IL98472A0 (en) 1992-07-15
IL98472A true IL98472A (en) 1995-08-31

Family

ID=26660803

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9847291A IL98472A (en) 1990-06-20 1991-06-12 Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and their pharmaceutical use

Country Status (29)

Country Link
US (1) US5430042A (de)
EP (1) EP0593463B1 (de)
JP (1) JP3049367B2 (de)
CN (1) CN1058213A (de)
AP (1) AP253A (de)
AT (1) ATE184602T1 (de)
AU (1) AU649456B2 (de)
BG (1) BG97198A (de)
CA (1) CA2083606C (de)
CZ (1) CZ279434B6 (de)
DE (1) DE69131627T2 (de)
EG (1) EG19752A (de)
ES (1) ES2140391T3 (de)
FI (1) FI925767A0 (de)
HU (1) HUT62882A (de)
IE (1) IE912026A1 (de)
IL (1) IL98472A (de)
IS (1) IS3720A7 (de)
LV (1) LV10269B (de)
MA (1) MA22198A1 (de)
NO (1) NO924650D0 (de)
NZ (1) NZ238545A (de)
OA (1) OA09683A (de)
PL (2) PL165898B1 (de)
PT (1) PT98036A (de)
RO (1) RO110497B1 (de)
TN (1) TNSN91050A1 (de)
WO (1) WO1991019712A1 (de)
YU (1) YU104091A (de)

Families Citing this family (63)

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SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
TNSN95062A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux derives dialkoxy-pyridinyle-benzimidazole
EE03305B1 (et) * 1994-07-08 2000-12-15 Astra Aktiebolag Paljuosaline tableteeritud annusvorm I
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5545661A (en) * 1995-05-16 1996-08-13 Eli Lilly And Company Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
EP0983263A1 (de) * 1997-05-30 2000-03-08 Dr. Reddy's Research Foundation Benzimidazol-derivate verwendbar als antiulcer-mittel, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
EP1300406B1 (de) * 1997-07-11 2004-10-06 Eisai Co., Ltd. Verfahren zur Herstellung von Pyridinderivaten
GB9805558D0 (en) * 1998-03-17 1998-05-13 Knoll Ag Chemical process`
NZ510180A (en) 1998-08-10 2002-11-26 Univ California Prodrugs of the pyridyl-methylsulphonyl-benzimidazole type proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
CA2480826C (fr) 2002-04-09 2012-02-07 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
DE60304726T2 (de) * 2002-07-19 2007-08-09 Winston Pharmaceuticals Llc, Newport Beach Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
US20040248942A1 (en) * 2003-02-20 2004-12-09 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
WO2004112756A1 (en) * 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
WO2005007117A2 (en) * 2003-07-18 2005-01-27 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
JP2007523164A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターに関連する化合物の静脈内投与のための方法および組成物
BRPI0507784A (pt) * 2004-02-18 2007-07-17 Allergan Inc métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons
TW200606163A (en) * 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
AU2005268056B2 (en) * 2004-08-06 2008-07-31 Eisai R&D Management Co., Ltd. Salts of benzimidazole derivative with amines and process for production thereof
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CA2648280C (en) 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
PL2046334T3 (pl) 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
JP2009196894A (ja) * 2006-10-13 2009-09-03 Eisai R & D Management Co Ltd スルフィニルベンズイミダゾール化合物またはその塩の製造方法
WO2008047681A1 (en) 2006-10-13 2008-04-24 Eisai R & D Management Co., Ltd. Benzimidazole compound having gastric acid secretion inhibitory activity
EP2086543A2 (de) 2006-10-27 2009-08-12 The Curators of the University of Missouri Zusammensetzungen mit mindestens einem säurelabilen protonenpumpen-hemmenden mittel, wahlweise anderen pharmazeutisch wirksamen mitteln und anwendungsverfahren dafür
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
JP2011512416A (ja) 2008-02-20 2011-04-21 ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法
BRPI0918492A2 (pt) 2008-09-09 2015-12-01 Astrazeneca Ab uso de naproxen, ou sal farmaceuticamente aceitável do mesmo, e esomeprazol, ou sal farmaceuticamente aceitável do mesmo
EP2445499A4 (de) 2009-06-25 2013-02-27 Astrazeneca Ab Verfahren zur behandlung eines patienten mit risiko der entwicklung eines nsaid-assoziierten geschwürs
WO2011080501A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
UA115139C2 (uk) 2011-12-28 2017-09-25 Поузен Інк. Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
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DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
KR890701580A (ko) * 1987-10-30 1989-12-21 앤더스 베딘 골(骨)손실에 관련된 질병 치료용 2-피리디닐메틸(술피닐 또는 티오) 벤즈이미다졸
WO1989005299A1 (fr) * 1987-12-11 1989-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux derives benzoglyoxaline
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen
SE8804628D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New compounds
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles

Also Published As

Publication number Publication date
ES2140391T3 (es) 2000-03-01
CA2083606A1 (en) 1991-12-21
CS189391A3 (en) 1992-06-17
CN1058213A (zh) 1992-01-29
NO924650L (no) 1992-12-02
EG19752A (en) 1996-01-31
NZ238545A (en) 1993-08-26
FI925767A7 (fi) 1992-12-18
LV10269A (lv) 1994-10-20
CZ279434B6 (cs) 1995-04-12
HU9204034D0 (en) 1993-03-29
EP0593463A1 (de) 1994-04-27
AP9100286A0 (en) 1991-07-31
AU649456B2 (en) 1994-05-26
YU104091A (sh) 1994-01-20
PL297294A1 (de) 1992-07-13
TNSN91050A1 (fr) 1992-10-25
NO924650D0 (no) 1992-12-02
LV10269B (en) 1995-10-20
RO110497B1 (ro) 1996-01-30
WO1991019712A1 (en) 1991-12-26
JP3049367B2 (ja) 2000-06-05
MA22198A1 (fr) 1992-04-01
OA09683A (en) 1993-05-15
US5430042A (en) 1995-07-04
CA2083606C (en) 2001-08-21
AP253A (en) 1993-05-03
DE69131627T2 (de) 2000-04-27
IS3720A7 (is) 1991-12-21
EP0593463B1 (de) 1999-09-15
PL166209B1 (pl) 1995-04-28
PL165898B1 (pl) 1995-02-28
PL297295A1 (de) 1992-07-13
PT98036A (pt) 1992-03-31
ATE184602T1 (de) 1999-10-15
BG97198A (bg) 1993-12-24
DE69131627D1 (de) 1999-10-21
HUT62882A (en) 1993-06-28
IL98472A0 (en) 1992-07-15
FI925767A0 (fi) 1992-12-18
IE912026A1 (en) 1992-01-01
JPH05507714A (ja) 1993-11-04
AU8061791A (en) 1992-01-07

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Legal Events

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RH Patent void