IL98330A - 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations - Google Patents

4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations

Info

Publication number
IL98330A
IL98330A IL9833091A IL9833091A IL98330A IL 98330 A IL98330 A IL 98330A IL 9833091 A IL9833091 A IL 9833091A IL 9833091 A IL9833091 A IL 9833091A IL 98330 A IL98330 A IL 98330A
Authority
IL
Israel
Prior art keywords
amino
propylpiperazin
trichlorophenyl
pyrimidine
acid addition
Prior art date
Application number
IL9833091A
Other languages
English (en)
Hebrew (he)
Other versions
IL98330A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to IL113599A priority Critical patent/IL113599A/xx
Publication of IL98330A0 publication Critical patent/IL98330A0/xx
Publication of IL98330A publication Critical patent/IL98330A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
IL9833091A 1990-06-01 1991-05-31 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations IL98330A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL113599A IL113599A (en) 1990-06-01 1991-05-31 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (2)

Publication Number Publication Date
IL98330A0 IL98330A0 (en) 1992-06-21
IL98330A true IL98330A (en) 1996-10-31

Family

ID=10676964

Family Applications (2)

Application Number Title Priority Date Filing Date
IL9833091A IL98330A (en) 1990-06-01 1991-05-31 4-Amino-N-4) -2-propylpirazine-1-il (-5-) 2,3,5-trichlorophenyl (and its acidic salt salts, history of pyrimidine, their preparation and pharmaceutical preparations
IL113599A IL113599A (en) 1990-06-01 1991-05-31 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL113599A IL113599A (en) 1990-06-01 1991-05-31 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
EP (2) EP0459819B1 (da)
JP (1) JPH06340634A (da)
KR (1) KR920000733A (da)
AT (1) ATE141263T1 (da)
AU (2) AU652753B2 (da)
CA (1) CA2043640A1 (da)
CZ (1) CZ281070B6 (da)
DE (1) DE69121317T2 (da)
DK (1) DK0459819T3 (da)
ES (1) ES2093078T3 (da)
FI (1) FI912623A (da)
GB (1) GB9012316D0 (da)
GR (1) GR3021237T3 (da)
HU (2) HUT58707A (da)
IE (1) IE911861A1 (da)
IL (2) IL98330A (da)
MY (2) MY136248A (da)
NO (1) NO180375C (da)
NZ (3) NZ272001A (da)
PL (2) PL170373B1 (da)
PT (1) PT97827B (da)
RU (1) RU2091374C1 (da)
SK (1) SK278444B6 (da)
TW (1) TW224460B (da)
ZA (1) ZA914165B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
SK282071B6 (sk) * 1991-01-30 2001-10-08 The Wellcome Foundation Limited Tableta dispergovateľná vo vode a spôsob jej prípravy
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
AU5704594A (en) * 1992-12-18 1994-07-19 Wellcome Foundation Limited, The Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) * 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
RU2233273C3 (ru) 1999-09-16 2019-07-17 Мицубиси Танабе Φαρμα Корпорейшн Ароматические азотсодержащие 6-членные циклические соединения и фармацевтическая композиция
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
EP1277741A4 (en) 2000-04-28 2003-05-07 Tanabe Seiyaku Co CYCLE CONNECTIONS
US7205297B2 (en) 2000-07-24 2007-04-17 Krenitsky Pharmaceuticals, Inc. Substituted 5-alkynyl pyrimidines having neurotrophic activity
NZ527741A (en) 2001-02-26 2005-02-25 Tanabe Seiyaku Co Pyridopyrimidine or naphthyridine derivative
EP1474401A2 (en) * 2002-02-05 2004-11-10 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
EP2233470B1 (en) 2005-07-04 2011-12-07 High Point Pharmaceuticals, LLC Histamine H3 receptor antagonists
JP2009537596A (ja) 2006-05-23 2009-10-29 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用
SG163547A1 (en) 2006-05-29 2010-08-30 High Point Pharmaceuticals Llc 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
BR112013030442B1 (pt) 2011-06-10 2021-11-09 Merck Patent Gmbh Compostos de pirimidina e piridina com atividade inibidora de btk, seus usos, composição, e kit
ES2699351T3 (es) * 2014-01-17 2019-02-08 Novartis Ag Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
CA3023216A1 (en) 2016-06-14 2017-12-21 Novartis Ag Compounds and compositions for inhibiting the activity of shp2
WO2018130928A1 (en) 2017-01-10 2018-07-19 Novartis Ag Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (da) *
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
AU6745594A (en) 1994-09-15
CZ281070B6 (cs) 1996-06-12
RU2091374C1 (ru) 1997-09-27
KR920000733A (ko) 1992-01-29
HU211649A9 (en) 1995-12-28
PT97827A (pt) 1992-03-31
ATE141263T1 (de) 1996-08-15
EP0459819A2 (en) 1991-12-04
AU652753B2 (en) 1994-09-08
HUT58707A (en) 1992-03-30
AU680252B2 (en) 1997-07-24
FI912623A0 (fi) 1991-05-31
GB9012316D0 (en) 1990-07-18
IL113599A (en) 1997-09-30
NZ238360A (en) 1997-03-24
DK0459819T3 (da) 1996-09-02
ZA914165B (en) 1993-03-01
JPH06340634A (ja) 1994-12-13
PT97827B (pt) 1998-10-30
TW224460B (da) 1994-06-01
NZ272001A (en) 1997-03-24
CA2043640A1 (en) 1991-12-02
EP0679645A1 (en) 1995-11-02
EP0459819B1 (en) 1996-08-14
AU7809791A (en) 1991-12-05
MY136248A (en) 2008-08-29
NO912100D0 (no) 1991-05-31
ES2093078T3 (es) 1996-12-16
NO180375B (no) 1996-12-30
PL170373B1 (pl) 1996-12-31
DE69121317D1 (de) 1996-09-19
NO180375C (no) 1997-04-09
NZ248501A (en) 1997-03-24
SK278444B6 (en) 1997-05-07
IE911861A1 (en) 1991-12-04
IL113599A0 (en) 1995-08-31
CS164391A3 (en) 1992-02-19
DE69121317T2 (de) 1997-01-02
HU911826D0 (en) 1991-12-30
NO912100L (no) 1991-12-02
IL98330A0 (en) 1992-06-21
PL166656B1 (pl) 1995-06-30
FI912623A (fi) 1991-12-02
EP0459819A3 (en) 1992-03-11
GR3021237T3 (en) 1997-01-31
MY109958A (en) 1997-10-31

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