IL97993A0 - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- IL97993A0 IL97993A0 IL97993A IL9799391A IL97993A0 IL 97993 A0 IL97993 A0 IL 97993A0 IL 97993 A IL97993 A IL 97993A IL 9799391 A IL9799391 A IL 9799391A IL 97993 A0 IL97993 A0 IL 97993A0
- Authority
- IL
- Israel
- Prior art keywords
- csf
- ser
- residue
- derivatives
- naturally occurring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/145—Colony stimulating factor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909009623A GB9009623D0 (en) | 1990-04-30 | 1990-04-30 | Polypeptides |
| GB909013773A GB9013773D0 (en) | 1990-06-20 | 1990-06-20 | Polypeptides |
| GB909016215A GB9016215D0 (en) | 1990-07-24 | 1990-07-24 | Polypeptides |
| GB919102799A GB9102799D0 (en) | 1991-02-11 | 1991-02-11 | Polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL97993A0 true IL97993A0 (en) | 1992-06-21 |
Family
ID=27450502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL97993A IL97993A0 (en) | 1990-04-30 | 1991-04-29 | Polypeptides |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5416195A (cs) |
| EP (1) | EP0459630B1 (cs) |
| JP (1) | JPH06100593A (cs) |
| KR (1) | KR910018406A (cs) |
| AT (1) | ATE169336T1 (cs) |
| AU (1) | AU644647B2 (cs) |
| BG (1) | BG94328A (cs) |
| CA (1) | CA2041454A1 (cs) |
| CS (1) | CS125091A3 (cs) |
| DE (1) | DE69129927T2 (cs) |
| DK (1) | DK0459630T3 (cs) |
| ES (1) | ES2118737T3 (cs) |
| FI (1) | FI912086A7 (cs) |
| GB (1) | GB9107846D0 (cs) |
| GR (1) | GR3027590T3 (cs) |
| HU (1) | HUT60769A (cs) |
| IE (1) | IE911440A1 (cs) |
| IL (1) | IL97993A0 (cs) |
| NO (1) | NO911696L (cs) |
| NZ (1) | NZ237974A (cs) |
| PT (1) | PT97529A (cs) |
| TW (1) | TW226022B (cs) |
| ZW (1) | ZW4891A1 (cs) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| IE912365A1 (en) * | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| AU7795094A (en) * | 1993-09-15 | 1995-04-03 | New York University | Dna sequence which binds transcriptional regulatory proteins activated in response to various cytokines and uses thereof |
| US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5573911A (en) * | 1994-10-03 | 1996-11-12 | Lifecodes Corp. | Methods and materials for detecting autoimmune antibodies |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| IT1285405B1 (it) * | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
| KR100440460B1 (ko) * | 1998-07-08 | 2004-10-08 | 주식회사유한양행 | 인체 과립구 콜로니 자극인자의 유전자, 재조합 벡터 및 형질 전환체 및 그들을 이용한 인체 과립구 콜로니 자극인자의 제조방법 |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| CA2357811A1 (en) * | 1999-01-06 | 2000-07-13 | Xencor, Inc. | Nucleic acids and proteins corresponding to mutants of g-csf with granulopoietic activity |
| US7208473B2 (en) | 1999-01-06 | 2007-04-24 | Xencor, Inc. | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
| KR100356140B1 (ko) * | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
| US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| KR100408429B1 (ko) * | 2000-01-24 | 2003-12-06 | 한미약품 주식회사 | 유즙 중에 인간 과립구 콜로니 자극인자를 생산하는형질전환 흑염소 |
| DK1129720T3 (da) | 2000-02-29 | 2004-09-27 | Pfizer Prod Inc | Stabiliseret granulocyt-kolonistimulerende faktor |
| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| AU2001273388B2 (en) | 2000-09-08 | 2005-01-13 | Gryphon Therapeutics, Inc. | "Pseudo"-native chemical ligation |
| WO2002020767A2 (en) | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| MXPA03007316A (es) | 2001-02-19 | 2003-12-04 | Merck Patent Gmbh | Metodo para la identificacion de epitopes de celulas t y el uso para la preparacion de moleculas con inmunogenicidad reducida. |
| IL159524A0 (en) * | 2001-07-11 | 2004-06-01 | Maxygen Holdings Ltd | G-csf conjugates |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| CN105131104B (zh) | 2001-10-10 | 2018-11-16 | 诺和诺德公司 | 肽的重构和糖缀合 |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| WO2003078461A1 (en) | 2002-03-20 | 2003-09-25 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
| ES2403932T3 (es) | 2002-08-27 | 2013-05-22 | Biokine Therapeutics Ltd. | Antagonista de CXCR4 y uso del mismo |
| CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| AU2004221824B2 (en) | 2003-03-14 | 2009-08-27 | Ratiopharm Gmbh | Branched water-soluble polymers and their conjugates |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| EP2198876B1 (en) * | 2003-10-24 | 2012-12-05 | Nora Therapeutics, Inc. | A method for reducing the likelihood of implantation failure in a subject |
| US8338373B2 (en) * | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
| US20090226397A1 (en) * | 2003-10-24 | 2009-09-10 | Nora Therapeutics, Inc. | Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination |
| US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| ES2560657T3 (es) * | 2004-01-08 | 2016-02-22 | Ratiopharm Gmbh | Glicosilación con unión en O de péptidos G-CSF |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| PL2586456T3 (pl) | 2004-10-29 | 2016-07-29 | Ratiopharm Gmbh | Remodeling i glikopegilacja czynnika wzrostu fibroblastów (FGF) |
| EP1817047B1 (en) | 2004-11-05 | 2012-02-08 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| EP1871795A4 (en) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE |
| EP1891231A4 (en) | 2005-05-25 | 2011-06-22 | Novo Nordisk As | GLYCOPEGYLATED FACTOR IX |
| US7381805B2 (en) | 2005-06-01 | 2008-06-03 | Maxygen Holdings, Ltd. | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF |
| KR100694994B1 (ko) * | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | 사람 과립구 콜로니 형성인자 동종체 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP1994138B1 (en) * | 2006-03-06 | 2014-04-30 | Cadila Healthcare Limited | Process for preparing human g-csf |
| US20080248959A1 (en) | 2006-07-21 | 2008-10-09 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| JP2010505874A (ja) | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー/エス | ポリペプチドコンジュゲートの精製方法 |
| EP2759302A3 (en) | 2006-12-21 | 2014-11-05 | Biokine Therapeutics LTD. | 4F-benzoyl-TN14003 combined with rituximab for use in the treatment of a tumour |
| BRPI0809670A8 (pt) | 2007-04-03 | 2018-12-18 | Biogenerix Ag | métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral. |
| MX2009013259A (es) | 2007-06-12 | 2010-01-25 | Novo Nordisk As | Proceso mejorado para la produccion de azucares de nucleotidos. |
| CA2697265A1 (en) | 2007-08-09 | 2009-02-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| NZ583276A (en) | 2007-08-27 | 2012-06-29 | Biogenerix Ag | Liquid formulations of granulocyte colony stimulating factor and polymer conjugates |
| WO2009046015A2 (en) | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| ES2476690T3 (es) | 2008-02-27 | 2014-07-15 | Novo Nordisk A/S | Moléculas conjugadas del Factor VIII |
| WO2009139784A1 (en) * | 2008-05-13 | 2009-11-19 | Nora Therapeutics, Inc. | Human g-csf analogs and methods of making and using thereof |
| WO2010011767A2 (en) | 2008-07-22 | 2010-01-28 | Duke Debra M | Compositions and methods for treating symptoms associated with menopause, hormonal variations and arthritis |
| PT2318029T (pt) * | 2008-07-23 | 2018-01-10 | Ambrx Inc | Polipéptidos de g-csf bovino modificados e suas utilizações |
| US9151289B2 (en) | 2008-08-21 | 2015-10-06 | Cummins Inc. | Fuel pump |
| WO2010092571A2 (en) | 2009-02-11 | 2010-08-19 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
| MX2011013459A (es) | 2009-06-14 | 2012-05-08 | Biokine Therapeutics Ltd | Terapia de peptido para incrementar los niveles de plaquetas. |
| WO2011090305A2 (en) | 2010-01-19 | 2011-07-28 | Hanmi Holdings Co., Ltd | Liquid formulations for long-acting g-csf conjugate |
| NZ602255A (en) | 2010-03-04 | 2014-04-30 | Pfenex Inc | Method for producing soluble recombinant interferon protein without denaturing |
| CA2794740C (en) | 2010-04-01 | 2019-12-31 | Pfenex Inc. | Methods for g-csf production in a pseudomonas host cell |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| CN102796197B (zh) * | 2011-05-24 | 2013-12-25 | 杭州九源基因工程有限公司 | 一种hsa-gcsf突变体及其制备方法 |
| EP2841084B1 (en) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer |
| WO2015057724A1 (en) | 2013-10-14 | 2015-04-23 | Nora Therapeutics, Inc. | Use of g-csf for treating or preventing villitis of unknown etiology in a human female |
| EP3322431A2 (en) | 2015-07-16 | 2018-05-23 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
| JP7222710B2 (ja) | 2015-09-24 | 2023-02-15 | ハンミ ファーマシューティカル カンパニー リミテッド | 免疫グロブリン断片の特定位置を連結部位として用いたタンパク質結合体 |
| KR102033920B1 (ko) | 2016-02-23 | 2019-10-18 | 바이오라인알엑스 리미티드 | 급성 골수성 백혈병을 치료하는 방법 |
| WO2023196818A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Genetic complementation compositions and methods |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| DK203187A (da) * | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| DK174044B1 (da) * | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| AU621051B2 (en) * | 1987-04-28 | 1992-03-05 | Amgen, Inc. | Method for purifying granulocyte-macrophage colony stimulating factor |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| NZ229098A (en) * | 1988-05-13 | 1992-10-28 | Amgen Inc | (bg-csf) bovine granulocyte colony stimulating factor, recombinant methods and pharmaceuticals |
| ATE118544T1 (de) * | 1988-05-31 | 1995-03-15 | Cetus Oncology Corp | Verfahren zur gewinnung von heterologe proteine enthaltenden refraktilkörpern aus mikrobiellen wirten. |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| JP2989002B2 (ja) * | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| DE4014750A1 (de) * | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
-
1991
- 1991-04-12 GB GB919107846A patent/GB9107846D0/en active Pending
- 1991-04-26 AU AU76284/91A patent/AU644647B2/en not_active Ceased
- 1991-04-29 ZW ZW48/91A patent/ZW4891A1/xx unknown
- 1991-04-29 EP EP91303868A patent/EP0459630B1/en not_active Expired - Lifetime
- 1991-04-29 NO NO91911696A patent/NO911696L/no unknown
- 1991-04-29 AT AT91303868T patent/ATE169336T1/de not_active IP Right Cessation
- 1991-04-29 ES ES91303868T patent/ES2118737T3/es not_active Expired - Lifetime
- 1991-04-29 CA CA002041454A patent/CA2041454A1/en not_active Abandoned
- 1991-04-29 BG BG094328A patent/BG94328A/bg unknown
- 1991-04-29 NZ NZ237974A patent/NZ237974A/xx unknown
- 1991-04-29 IL IL97993A patent/IL97993A0/xx unknown
- 1991-04-29 US US07/692,995 patent/US5416195A/en not_active Expired - Lifetime
- 1991-04-29 HU HU911440A patent/HUT60769A/hu unknown
- 1991-04-29 DE DE69129927T patent/DE69129927T2/de not_active Expired - Lifetime
- 1991-04-29 DK DK91303868T patent/DK0459630T3/da active
- 1991-04-29 IE IE144091A patent/IE911440A1/en unknown
- 1991-04-30 FI FI912086A patent/FI912086A7/fi unknown
- 1991-04-30 KR KR1019910006926A patent/KR910018406A/ko not_active Withdrawn
- 1991-04-30 JP JP3228192A patent/JPH06100593A/ja active Pending
- 1991-04-30 PT PT97529A patent/PT97529A/pt not_active Application Discontinuation
- 1991-04-30 CS CS911250A patent/CS125091A3/cs unknown
- 1991-04-30 TW TW080103367A patent/TW226022B/zh active
-
1998
- 1998-08-06 GR GR980400784T patent/GR3027590T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3027590T3 (en) | 1998-11-30 |
| EP0459630B1 (en) | 1998-08-05 |
| NZ237974A (en) | 1993-09-27 |
| JPH06100593A (ja) | 1994-04-12 |
| KR910018406A (ko) | 1991-11-30 |
| CA2041454A1 (en) | 1991-10-31 |
| GB9107846D0 (en) | 1991-05-29 |
| US5416195A (en) | 1995-05-16 |
| HUT60769A (en) | 1992-10-28 |
| BG94328A (bg) | 1993-12-24 |
| CS125091A3 (en) | 1992-02-19 |
| PT97529A (pt) | 1992-01-31 |
| NO911696L (no) | 1991-10-31 |
| AU644647B2 (en) | 1993-12-16 |
| EP0459630A3 (en) | 1992-10-21 |
| TW226022B (cs) | 1994-07-01 |
| FI912086A0 (fi) | 1991-04-30 |
| FI912086L (fi) | 1991-10-31 |
| EP0459630A2 (en) | 1991-12-04 |
| ES2118737T3 (es) | 1998-10-01 |
| AU7628491A (en) | 1991-11-14 |
| DE69129927T2 (de) | 1999-04-01 |
| NO911696D0 (no) | 1991-04-29 |
| HU911440D0 (en) | 1991-11-28 |
| FI912086A7 (fi) | 1991-10-31 |
| ZW4891A1 (en) | 1992-01-01 |
| ATE169336T1 (de) | 1998-08-15 |
| DK0459630T3 (da) | 1999-05-03 |
| DE69129927D1 (de) | 1998-09-10 |
| IE911440A1 (en) | 1991-11-06 |
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