IL97602A - Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins - Google Patents

Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins

Info

Publication number
IL97602A
IL97602A IL9760291A IL9760291A IL97602A IL 97602 A IL97602 A IL 97602A IL 9760291 A IL9760291 A IL 9760291A IL 9760291 A IL9760291 A IL 9760291A IL 97602 A IL97602 A IL 97602A
Authority
IL
Israel
Prior art keywords
ngf
biologically active
bdnf
production
neurotrophic proteins
Prior art date
Application number
IL9760291A
Other languages
English (en)
Other versions
IL97602A0 (en
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27414291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL97602(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL97602A0 publication Critical patent/IL97602A0/xx
Publication of IL97602A publication Critical patent/IL97602A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
IL9760291A 1990-04-06 1991-03-19 Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins IL97602A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50544190A 1990-04-06 1990-04-06
US54775090A 1990-07-02 1990-07-02
US07/594,126 US5235043A (en) 1990-04-06 1990-10-09 Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins

Publications (2)

Publication Number Publication Date
IL97602A0 IL97602A0 (en) 1992-06-21
IL97602A true IL97602A (en) 2005-08-31

Family

ID=27414291

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9760291A IL97602A (en) 1990-04-06 1991-03-19 Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins

Country Status (17)

Country Link
US (1) US5235043A (no)
EP (1) EP0450386B1 (no)
JP (1) JP2521851B2 (no)
KR (1) KR910018545A (no)
AT (1) ATE183232T1 (no)
AU (1) AU651339B2 (no)
CA (1) CA2038669C (no)
DE (1) DE69131514T2 (no)
DK (1) DK0450386T3 (no)
ES (1) ES2140379T3 (no)
FI (1) FI108146B (no)
GR (1) GR3031632T3 (no)
IE (1) IE910827A1 (no)
IL (1) IL97602A (no)
NO (1) NO308308B1 (no)
NZ (1) NZ237544A (no)
TW (1) TW206258B (no)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
AU664021B2 (en) * 1990-09-05 1995-11-02 Natinco Nv Solubilization of proteins in active forms
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
PT100580A (pt) * 1991-06-12 1993-09-30 Regeneron Pharma Producao e recuperacao de neurotrofinas recombinantes
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
DE4139000A1 (de) 1991-11-27 1993-06-03 Boehringer Mannheim Gmbh Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
US5316921A (en) * 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
ATE222603T1 (de) * 1992-05-18 2002-09-15 Genentech Inc Hepatozytwachstumfaktor variante
EP0573904B1 (en) * 1992-06-08 2001-09-26 Takeda Chemical Industries, Ltd. Therapeutic agent for neutropenia
US5364645A (en) * 1992-10-30 1994-11-15 The Regents Of The University Of California Method of controlling microorganisms by pulsed ultraviolet laser radiation
EP0632008B1 (en) * 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentanoic acid derivatives
EP0724598B1 (en) * 1993-10-18 1999-01-13 Regeneron Pharmaceuticals, Inc. Growth factor heterodimers
US5470719A (en) * 1994-03-18 1995-11-28 Meng; Shi-Yuan Modified OmpA signal sequence for enhanced secretion of polypeptides
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5739307A (en) 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5607711A (en) * 1995-11-01 1997-03-04 The Regents Of The University Of California Method of controlling insects and mites with pulsed ultraviolet light
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
DE69732350T2 (de) 1996-03-14 2005-12-22 Washington University Persephin und verwandte wachstumsfaktoren
TR199802584T2 (xx) * 1996-06-11 1999-03-22 Boehringer Mannheim Gmbh Denat�re proteinin aktive edilmesi i�in y�ntem.
US5910435A (en) * 1996-07-25 1999-06-08 Wisconsin Alumni Research Foundation Method of folding proteins with synthetic dithiol catalysts
AU729459B2 (en) * 1996-11-15 2001-02-01 Genentech Inc. Purification of neurotrophins
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
ES2297889T3 (es) 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
ES2213861T3 (es) * 1998-10-09 2004-09-01 Scil Proteins Gmbh Procedimiento de obtencion de ngf-beta activa.
WO2000024415A2 (en) * 1998-10-28 2000-05-04 Cornell Research Foundation, Inc. Methods for regulating angiogenesis and vascular integrity using trk receptor ligands
US6329136B1 (en) 1998-10-30 2001-12-11 The Regents Of The University Of California Method for laser inactivation of infectious agents
CA2359345A1 (en) * 1999-01-14 2000-07-20 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US20020049303A1 (en) * 1999-06-28 2002-04-25 Tang Jordan J. N. Catalytically active recombinant memapsin and methods of use thereof
CA2374610A1 (en) * 1999-06-28 2001-01-04 Jordan J. N. Tang Catalytically active recombinant memapsin and methods of use thereof
EP1206578A2 (en) * 1999-08-11 2002-05-22 Whitehead Institute For Biomedical Research Bdnf polymorphism and association with bipolar disorder
US7223406B2 (en) 2000-07-21 2007-05-29 The Regents Of The University Of California Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
EP1365794A2 (en) * 2000-07-21 2003-12-03 Lue, Tom Prevention and treatment of sexual arousal disorders
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
EP1233075A3 (en) * 2001-02-15 2003-01-08 Whitehead Institute For Biomedical Research BDNF polymorphism and association with bipolar disorder
US20030232365A1 (en) * 2001-02-15 2003-12-18 Whitehead Institute For Biomedical Research BDNF polymorphisms and association with bipolar disorder
JP4547152B2 (ja) * 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
US20030219696A1 (en) * 2002-05-23 2003-11-27 Moreland Gerald W. Method and apparatus for preventing backflow in dental saliva evacuators
JP2005305107A (ja) * 2004-03-25 2005-11-04 Sei Matsuoka 価値的情報値の測定装置およびこれを使用した測定方法
CA2618508A1 (en) * 2005-08-10 2007-02-22 Oklahoma Medical Research Foundation Truncated memapsin 2 for use for treating alzheimer's disease
WO2008002572A2 (en) * 2006-06-27 2008-01-03 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for measuring mature brain derived neurotrophic factor
IT1394596B1 (it) * 2008-09-30 2012-07-05 Fond Parco Tecnologico Padano Produzione di ngf in pianta.
EP2594295A1 (en) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nerve implants based on a compacted biomaterial containing cells
GB201804641D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of sequencing nucleic acids and error correction of sequence reads
US20240033303A1 (en) * 2020-12-08 2024-02-01 Md Healthcare Inc. Composition for preventing or treating neurological diseases or psychiatric diseases comprising vesicles derived from sphingomonas bacteria
IT202000032423A1 (it) 2020-12-24 2022-06-24 Univ Degli Studi Di Trieste Metodo per la produzione di forme processate proteoliticamente di fattori trofici o fattori di crescita
EP4413993A1 (en) * 2023-02-10 2024-08-14 Dompe' Farmaceutici S.P.A. Method of obtaining recombinant human brain-derived neurotrophic factor
WO2025133858A1 (en) 2023-12-18 2025-06-26 Fondazione Istituto Italiano Di Tecnologia Functional nucleic acid molecule capable of increasing bdnf production

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
IT1219874B (it) * 1988-03-18 1990-05-24 Fidia Farmaceutici Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US6709837B1 (en) * 1989-03-10 2004-03-23 Takeda Chemical Industries, Inc. Polypeptide and production thereof
GR1000980B (el) * 1989-08-30 1993-03-31 Max Planck Gesellschaft Νευροτροφινη-3,ενας νεος neυροτροφικος παραγοντας που σχετιζεται με τον παραγοντα αναπτυξης νευρων και τον νευροτροφικο παραγοντα που προερχεται απο τον εγκεφαλο.
JPH05161493A (ja) * 1989-08-30 1993-06-29 Max Planck Ges Foerderung Wissenschaft Ev ニューロトロフィン―３
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor

Also Published As

Publication number Publication date
TW206258B (no) 1993-05-21
KR910018545A (ko) 1991-11-30
CA2038669A1 (en) 1991-10-07
DE69131514D1 (de) 1999-09-16
ATE183232T1 (de) 1999-08-15
NO911303L (no) 1991-10-07
JPH06319549A (ja) 1994-11-22
ES2140379T3 (es) 2000-03-01
DE69131514T2 (de) 2000-05-04
EP0450386A2 (en) 1991-10-09
DK0450386T3 (da) 2000-03-06
CA2038669C (en) 2004-06-29
GR3031632T3 (en) 2000-01-31
JP2521851B2 (ja) 1996-08-07
IE910827A1 (en) 1991-10-09
US5235043A (en) 1993-08-10
EP0450386A3 (en) 1992-09-09
EP0450386B1 (en) 1999-08-11
FI108146B (fi) 2001-11-30
AU651339B2 (en) 1994-07-21
NO911303D0 (no) 1991-04-03
FI911643L (fi) 1991-10-07
NO308308B1 (no) 2000-08-28
FI911643A0 (fi) 1991-04-05
IL97602A0 (en) 1992-06-21
NZ237544A (en) 1993-07-27
AU7413091A (en) 1991-11-14

Similar Documents

Publication Publication Date Title
EP0450386A3 (en) Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
HU9303182D0 (en) Truncated forms of the hepatocite growth factor (hgf) receptor pharmaceutical compositions containing them and process for production off them
CA2056997A1 (en) A human cytokine, interleukin-9
GR3026554T3 (en) Human CNP gene and precursor protein
EP0170204A3 (en) Genetic sequences, type i interferon peptide coded by them, and these organisms producing the same
EP0443874A3 (en) Vectors and compounds for expression of glycosylation mutants of human protein c
HUT43111A (en) Process for producing human lizozime
ES2017122A6 (es) Procedimiento de preparacion de proteina de ligado de heparina.
AR243237A1 (es) Un vector de expresion recombinante que contiene una secuencia de adn que codifica el factor neurotrofico ciliar humano,un microorganismo e.coli transformado,y linea celulares transformadas.
GB9104596D0 (en) Production of recombinant proteins
ZA911834B (en) Production of biologically active,recombinant members of the ngf/bdnf family of neurotrophic proteins
ZA932830B (en) A novel anti-neoplastic cytokine
FI955463L (fi) Menetelmä biologisesti aktiivisten polypeptidien tuottamiseksi rekombinanttitekniikalla
EP0473080A3 (en) Chondromodulin-i protein
HUT67352A (en) Recombinant ciliary neurotrophic factor and c-ferminal truncated ciliary neurotrophic factor, their production, and pharmaceutical products for treatment of peripheral nerveinjury, containing them
EP0288901A3 (en) Recombinant human glutathione peroxidase, process for preparing the same and dna coding the same
EP0645399A3 (de) Ribosome inaktivierendes Protein (RIP), Verfahren zu dessen Herstellung und das Ripenthaltende pharmazeutische Zubereitung.
ZA938572B (en) Improved recombinant protein production
HK1014557A (en) Method for recombinant production of biologically active polypeptides
IT1254703B (it) Processo per la sintesi e la purificazione di forme troncate del fattore neuronotrofico ciliare umano
DE69123242D1 (de) Physiologisch aktive Peptide, ihre Verwendung und eine Methode besagte Peptide herzustellen

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
EXP Patent expired