IL94254A - The competing tricyclicguanides of TH53. - Google Patents
The competing tricyclicguanides of TH53.Info
- Publication number
- IL94254A IL94254A IL9425490A IL9425490A IL94254A IL 94254 A IL94254 A IL 94254A IL 9425490 A IL9425490 A IL 9425490A IL 9425490 A IL9425490 A IL 9425490A IL 94254 A IL94254 A IL 94254A
- Authority
- IL
- Israel
- Prior art keywords
- indol
- thiazole
- product
- guanidinomethyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/349,189 US4963689A (en) | 1989-05-19 | 1989-05-19 | Heterocyclicguanidines as 5HT3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL94254A true IL94254A (en) | 1994-05-30 |
Family
ID=23371270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9425490A IL94254A (en) | 1989-05-19 | 1990-05-02 | The competing tricyclicguanides of TH53. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4963689A (ja) |
| EP (1) | EP0397364B1 (ja) |
| JP (1) | JPH0635454B2 (ja) |
| KR (1) | KR920003927B1 (ja) |
| AT (1) | ATE92062T1 (ja) |
| AU (1) | AU615385B2 (ja) |
| CA (1) | CA2016182C (ja) |
| DE (1) | DE69002384T2 (ja) |
| DK (1) | DK0397364T3 (ja) |
| ES (1) | ES2058795T3 (ja) |
| FI (1) | FI902291A0 (ja) |
| HU (1) | HUT58063A (ja) |
| IE (1) | IE62935B1 (ja) |
| IL (1) | IL94254A (ja) |
| MY (1) | MY105555A (ja) |
| NO (1) | NO902029L (ja) |
| NZ (1) | NZ233576A (ja) |
| PT (1) | PT93979B (ja) |
| ZA (1) | ZA903478B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5140034A (en) * | 1989-03-14 | 1992-08-18 | Merck Sharp & Dohme Ltd. | Five-membered ring systems with bonded imidazolyl ring substituents |
| WO1994006791A1 (en) * | 1992-09-14 | 1994-03-31 | Yamanouchi Pharmaceutical Co., Ltd. | Novel condensed thiazole derivative, process for producing the same, and pharmaceutical composition containing the same |
| MX9603998A (es) * | 1994-03-11 | 1997-12-31 | Yamanouchi Pharma Co Ltd | Agonista receptor de 5-ht3, derivado de tiazol novedoso e intermediario del mismo. |
| US5887415A (en) * | 1995-05-11 | 1999-03-30 | Bernard Matthews Plc | Cooked, extruded meat product comprising additive |
| US5811425A (en) * | 1997-03-04 | 1998-09-22 | Abbott Laboratories | Heterocyclic compounds as COX-2 inhibitors |
| DE102005027193A1 (de) * | 2005-06-06 | 2006-12-07 | Wilhelm Stahlecker Gmbh | Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine |
| PL2432467T3 (pl) | 2009-05-20 | 2018-07-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Zastosowanie antagonistów receptora 5-ht3 serotoniny w leczeniu zaburzeń przedsionkowych ze zmianami chorobowymi |
| ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1031165A (en) * | 1965-08-18 | 1966-05-25 | Wellcome Found | Guanidines, isoureas and isothioureas |
| GB1305549A (ja) * | 1969-10-29 | 1973-02-07 | ||
| DE2739723A1 (de) * | 1977-09-03 | 1979-03-08 | Merck Patent Gmbh | 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung |
| US4220654A (en) * | 1979-06-04 | 1980-09-02 | Merck & Co., Inc. | Cyclic imidazole cyanoguanidines |
| US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
-
1989
- 1989-05-19 US US07/349,189 patent/US4963689A/en not_active Expired - Lifetime
-
1990
- 1990-04-30 AT AT90304684T patent/ATE92062T1/de not_active IP Right Cessation
- 1990-04-30 ES ES90304684T patent/ES2058795T3/es not_active Expired - Lifetime
- 1990-04-30 EP EP90304684A patent/EP0397364B1/en not_active Expired - Lifetime
- 1990-04-30 DE DE90304684T patent/DE69002384T2/de not_active Expired - Fee Related
- 1990-04-30 DK DK90304684.5T patent/DK0397364T3/da active
- 1990-05-02 IL IL9425490A patent/IL94254A/en not_active IP Right Cessation
- 1990-05-07 AU AU54767/90A patent/AU615385B2/en not_active Ceased
- 1990-05-07 CA CA002016182A patent/CA2016182C/en not_active Expired - Fee Related
- 1990-05-07 MY MYPI90000733A patent/MY105555A/en unknown
- 1990-05-07 NZ NZ233576A patent/NZ233576A/en unknown
- 1990-05-08 PT PT93979A patent/PT93979B/pt not_active IP Right Cessation
- 1990-05-08 FI FI902291A patent/FI902291A0/fi not_active IP Right Cessation
- 1990-05-08 NO NO90902029A patent/NO902029L/no unknown
- 1990-05-08 ZA ZA903478A patent/ZA903478B/xx unknown
- 1990-05-08 KR KR1019900006421A patent/KR920003927B1/ko not_active IP Right Cessation
- 1990-05-08 IE IE166490A patent/IE62935B1/en not_active IP Right Cessation
- 1990-05-09 HU HU902976A patent/HUT58063A/hu unknown
- 1990-05-09 JP JP2119635A patent/JPH0635454B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HUT58063A (en) | 1992-01-28 |
| IE62935B1 (en) | 1995-03-08 |
| ATE92062T1 (de) | 1993-08-15 |
| ZA903478B (en) | 1991-12-24 |
| DE69002384D1 (de) | 1993-09-02 |
| HU902976D0 (en) | 1990-09-28 |
| MY105555A (en) | 1994-10-31 |
| NZ233576A (en) | 1991-06-25 |
| DK0397364T3 (da) | 1993-09-27 |
| NO902029L (no) | 1990-11-12 |
| AU5476790A (en) | 1990-11-15 |
| CA2016182C (en) | 1996-03-12 |
| EP0397364A1 (en) | 1990-11-14 |
| US4963689A (en) | 1990-10-16 |
| NO902029D0 (no) | 1990-05-08 |
| JPH0635454B2 (ja) | 1994-05-11 |
| KR900018054A (ko) | 1990-12-20 |
| DE69002384T2 (de) | 1993-11-18 |
| IE901664L (en) | 1990-11-09 |
| EP0397364B1 (en) | 1993-07-28 |
| ES2058795T3 (es) | 1994-11-01 |
| JPH0311070A (ja) | 1991-01-18 |
| KR920003927B1 (ko) | 1992-05-18 |
| PT93979A (pt) | 1991-01-08 |
| FI902291A0 (fi) | 1990-05-08 |
| CA2016182A1 (en) | 1990-11-09 |
| AU615385B2 (en) | 1991-09-26 |
| PT93979B (pt) | 1996-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU656859B2 (en) | Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent | |
| AU593278B2 (en) | Pharmaceutically active 2-thiomethyl-substituted-1,4- dihydropyridines | |
| JP4890723B2 (ja) | ＴＮＦαインヒビターとして有用なクマリン誘導体 | |
| EP0397365B1 (en) | Arylthiazolylimidazoles as 5HT3 Antagonists | |
| JPH054983A (ja) | イソキノリノン誘導体、その製造方法およびその誘導体を有効成分として含有する５−ｈｔ３ レセプター拮抗剤 | |
| WO2007129111A1 (en) | Diazepine derivatives as 5-ht2a antagonists | |
| JP6483700B2 (ja) | Ｔｎｆ活性のモジュレーターとしてのイミダゾチアゾール誘導体 | |
| JPH01249769A (ja) | 向精神性ヘテロビシクロアルキルピペラジン誘導体 | |
| CA2236683A1 (en) | Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof | |
| EP0397364B1 (en) | Heterocyclic guanidines as 5ht 3 antagonists | |
| HUT65947A (en) | Imidazo-pyridine - derivatives with paf/h1 antagonist activity and pharmaceutical compositions containing them and process for the production thereof | |
| US4818760A (en) | Derivatives of pyridylsulfinyl(benz-or thieno-)imidazoles and their use as gastric secretion inhibiting substances | |
| TWI325866B (en) | Camptothecins with a modified lactone ring | |
| Nagel et al. | Heterocyclicguanidines as 5HT 3 antagonists | |
| US5641782A (en) | 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides | |
| JPS62230788A (ja) | 抗潰瘍剤としての２−〔（２−ピリジル）メチルスルフイニル〕チエノイミダゾ−ル類 | |
| CA2030077C (en) | Azabicyclo amides and esters as 5-ht _receptor antagonists | |
| PL112834B1 (en) | Process for preparing 5-substituted 10,11-dihydro-5h-dibenzo/a,d/cycloheptene-5,10-imines | |
| HUT61760A (en) | Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds | |
| JPH037227A (ja) | ５―ｈｔ↓３レセプタ拮抗剤 | |
| JPH04234889A (ja) | ４Ｈ−ピロロ〔１，２−ａ〕チエノ〔３，２−ｆ〕〔１，４〕ジアゼピンの新規誘導体およびその製造方法 | |
| CA2357306A1 (en) | Fused ring system containing indole as m4 selective aza-anthracene muscarinic receptor antagonists | |
| FR2640975A1 (ja) | ||
| US20040019070A1 (en) | Pyrrole-condensed morphinoid derivatives | |
| WO1993012120A1 (en) | Pyrazolothiazolopyrimidine derivative |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH | Patent void |