IL92905A - History of insulin, the process for their preparation, and their use and the pharmaceutical preparations containing them - Google Patents

History of insulin, the process for their preparation, and their use and the pharmaceutical preparations containing them

Info

Publication number
IL92905A
IL92905A IL9290589A IL9290589A IL92905A IL 92905 A IL92905 A IL 92905A IL 9290589 A IL9290589 A IL 9290589A IL 9290589 A IL9290589 A IL 9290589A IL 92905 A IL92905 A IL 92905A
Authority
IL
Israel
Prior art keywords
insulin
formula
arg
human
appropriate
Prior art date
Application number
IL9290589A
Other languages
English (en)
Hebrew (he)
Other versions
IL92905A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL92905A0 publication Critical patent/IL92905A0/xx
Publication of IL92905A publication Critical patent/IL92905A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IL9290589A 1988-12-29 1989-12-27 History of insulin, the process for their preparation, and their use and the pharmaceutical preparations containing them IL92905A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3844211A DE3844211A1 (de) 1988-12-29 1988-12-29 Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (2)

Publication Number Publication Date
IL92905A0 IL92905A0 (en) 1990-09-17
IL92905A true IL92905A (en) 1994-10-21

Family

ID=6370457

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9290589A IL92905A (en) 1988-12-29 1989-12-27 History of insulin, the process for their preparation, and their use and the pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US5506202A (ko)
EP (1) EP0376156B1 (ko)
JP (1) JP3129722B2 (ko)
KR (1) KR900009698A (ko)
AT (1) ATE136038T1 (ko)
AU (1) AU623963B2 (ko)
CA (1) CA2006818C (ko)
DE (2) DE3844211A1 (ko)
DK (1) DK173178B1 (ko)
ES (1) ES2085271T3 (ko)
FI (1) FI102843B1 (ko)
GR (1) GR3019560T3 (ko)
HU (1) HU205172B (ko)
IE (1) IE73672B1 (ko)
IL (1) IL92905A (ko)
NO (1) NO180379C (ko)
NZ (1) NZ231944A (ko)
PH (1) PH27425A (ko)
PT (1) PT92757B (ko)
ZA (1) ZA899946B (ko)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
HUP9800523A3 (en) * 1995-03-17 1998-09-28 Novo Nordisk As Insulin derivatives
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US20050014679A1 (en) * 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
EP1814575A4 (en) * 2004-11-24 2010-07-07 Neopro Labs Llc METHODS AND COMPOSITIONS FOR TREATING DISORDERS
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
PL373543A1 (pl) * 2005-03-10 2006-09-18 Instytut Biotechnologii i Antybiotyków Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
US20060212009A1 (en) * 2005-03-16 2006-09-21 Accisano Nicholas G Iii Drainage catheter hub with rotatable lever handle
US7824367B2 (en) * 2005-08-17 2010-11-02 Merit Medical Systems, Inc. Drainage catheter with locking hub
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
US7557088B2 (en) * 2006-03-28 2009-07-07 Neopro Labs, Llc Methods and compositions for treating conditions
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
JP5550338B2 (ja) 2006-07-31 2014-07-16 ノボ・ノルデイスク・エー／エス ペグ化持続型インスリン
US9233226B2 (en) * 2006-08-22 2016-01-12 Merit Medical Systems, Inc. Drainage catheter with pig-tail straightener
US9018161B2 (en) 2006-09-22 2015-04-28 Novo Nordisk A/S Protease resistant insulin analogues
EP2074140B8 (en) * 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
WO2008144675A1 (en) 2007-05-17 2008-11-27 Neopro Labs, Llc Crystalline and amorphous forms of peptide
WO2008145730A1 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
WO2009012472A2 (en) * 2007-07-18 2009-01-22 Neopro Labs, Llc Methods and compositions for treating conditions
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
PL2254906T3 (pl) 2008-03-18 2017-04-28 Novo Nordisk A/S Stabilizowane względem proteaz, acylowane analogi insuliny
WO2009129250A2 (en) * 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
BRPI0911571A2 (pt) * 2008-04-22 2018-04-03 Univ Case Western Reserve método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
WO2011072288A2 (en) 2009-12-11 2011-06-16 Case Western Reserve University Insulin analogues with chlorinated amino acids
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
SI3055325T1 (en) 2013-10-07 2018-05-31 Novo Nordisk A/S NEW DERIVATIVE ANALOGUE INSULINE
KR102569743B1 (ko) 2014-10-06 2023-08-23 케이스 웨스턴 리저브 유니버시티 이상 단일 사슬 인슐린 유사체
GB2549275B (en) * 2016-04-11 2018-05-09 Tectonic Facades Ltd Construction assembly
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
WO2024137820A1 (en) * 2022-12-20 2024-06-27 The Board Of Trustees Of The Leland Stanford Junior University Insulin receptor antagonist

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DE3636903A1 (de) * 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545595A1 (de) * 1985-12-21 1987-06-25 Behringwerke Ag Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
FI102843B (fi) 1999-02-26
IE894200L (en) 1990-06-29
CA2006818C (en) 2000-05-23
FI102843B1 (fi) 1999-02-26
NO895296L (no) 1990-07-02
PT92757A (pt) 1990-06-29
DE3844211A1 (de) 1990-07-05
HUT53150A (en) 1990-09-28
JP3129722B2 (ja) 2001-01-31
ATE136038T1 (de) 1996-04-15
HU205172B (en) 1992-03-30
NO180379C (no) 1997-04-09
EP0376156A3 (de) 1991-05-02
EP0376156A2 (de) 1990-07-04
DK173178B1 (da) 2000-03-06
ZA899946B (en) 1990-09-26
US5506202A (en) 1996-04-09
FI896279A0 (fi) 1989-12-27
CA2006818A1 (en) 1990-06-29
DE58909633D1 (de) 1996-05-02
AU4733289A (en) 1990-07-05
ES2085271T3 (es) 1996-06-01
IE73672B1 (en) 1997-07-02
EP0376156B1 (de) 1996-03-27
HU896781D0 (en) 1990-03-28
PH27425A (en) 1993-06-21
KR900009698A (ko) 1990-07-05
DK669889D0 (da) 1989-12-28
NO180379B (no) 1996-12-30
DK669889A (da) 1990-06-30
GR3019560T3 (en) 1996-07-31
NO895296D0 (no) 1989-12-28
PT92757B (pt) 1995-12-29
AU623963B2 (en) 1992-05-28
IL92905A0 (en) 1990-09-17
NZ231944A (en) 1993-02-25
JPH02225498A (ja) 1990-09-07

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