IL92856A - Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches - Google Patents

Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches

Info

Publication number
IL92856A
IL92856A IL9285689A IL9285689A IL92856A IL 92856 A IL92856 A IL 92856A IL 9285689 A IL9285689 A IL 9285689A IL 9285689 A IL9285689 A IL 9285689A IL 92856 A IL92856 A IL 92856A
Authority
IL
Israel
Prior art keywords
mismatch repair
strain
mismatches
defective
recombination
Prior art date
Application number
IL9285689A
Other languages
English (en)
Other versions
IL92856A0 (en
Original Assignee
Setratech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setratech filed Critical Setratech
Publication of IL92856A0 publication Critical patent/IL92856A0/xx
Publication of IL92856A publication Critical patent/IL92856A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9285689A 1988-12-26 1989-12-22 Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches IL92856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817185A FR2641793B1 (fr) 1988-12-26 1988-12-26 Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases

Publications (2)

Publication Number Publication Date
IL92856A0 IL92856A0 (en) 1990-09-17
IL92856A true IL92856A (en) 2001-04-30

Family

ID=9373422

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9285689A IL92856A (en) 1988-12-26 1989-12-22 Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches

Country Status (13)

Country Link
US (2) US5912119A (de)
EP (1) EP0449923B1 (de)
JP (1) JP3056524B2 (de)
AT (1) ATE127519T1 (de)
AU (1) AU4834390A (de)
CA (1) CA2006549C (de)
DE (1) DE68924174T2 (de)
ES (1) ES2077058T3 (de)
FR (1) FR2641793B1 (de)
IE (1) IE72469B1 (de)
IL (1) IL92856A (de)
WO (1) WO1990007576A1 (de)
ZA (1) ZA899902B (de)

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US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
CA2263958C (en) * 1995-07-26 2012-06-19 Mixis France Homologous recombination in mismatch repair inactivated eukaryotic cells
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6489145B1 (en) * 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
CN1210557A (zh) * 1996-01-10 1999-03-10 诺沃挪第克公司 用于在细胞中体内产生突变体文库方法
US6165718A (en) 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
WO1997037011A1 (en) * 1996-04-01 1997-10-09 Setratech S.A.R.L. Meiotic recombination in vivo of partially homologous dna sequences
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
CN1208456C (zh) * 1996-12-20 2005-06-29 诺维信公司 体内重组
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU6029998A (en) 1997-01-17 1998-08-07 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
DK1717322T3 (da) 1997-01-17 2012-10-22 Codexis Mayflower Holdings Llc Udvikling af hele celler og organismer ved rekursiv sekvensrekombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
EP1036198B1 (de) 1997-12-08 2012-09-26 California Institute Of Technology Verfahren zur Herstellung von Polynukleotid- und Polypeptidsequenzen
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) * 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
EP1151409A1 (de) * 1999-01-18 2001-11-07 Maxygen, Inc. Verfahren zum bevölkern von datenstrukturen für evolutionäre-simulationen
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
AU3210100A (en) 1999-01-19 2000-08-01 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US6518042B1 (en) 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
EP1157095A1 (de) * 1999-02-24 2001-11-28 Novozymes A/S Pilzzellen mit inaktiviertem dna-mismatch reparatursystem
US7430477B2 (en) * 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US20020088021A1 (en) * 2000-09-18 2002-07-04 Mahajan Pramod B. Rice MLH1 ortholog and uses thereof
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
EP1474522B1 (de) * 2002-01-18 2012-03-07 Morphotek, Inc. Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
ES2259685T3 (es) * 2002-01-31 2006-10-16 Mixis France S.A. Procedimiento para la inactivacion funcional reversible del sistema de reparacion del desapareamiento.
AU2003231244A1 (en) * 2002-05-02 2003-11-17 University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
NZ551993A (en) * 2004-07-06 2009-12-24 Mixis France Sa Generation of recombinant genes in a bacteriophage and a bacterial host cell.
EP1734125A1 (de) * 2005-06-16 2006-12-20 Institut National De La Recherche Agronomique Homeologische Rekombination in MSH2 inaktivierten Pflanzen oder deren Zellen
US20080124355A1 (en) * 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US8603792B2 (en) 2009-03-27 2013-12-10 Life Technologies Corporation Conjugates of biomolecules to nanoparticles
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WO2012113827A1 (en) 2011-02-24 2012-08-30 Eucodis Bioscience Gmbh Feed processing enzymes
US20140200145A1 (en) 2011-06-21 2014-07-17 Eviagenics S.A. Method of metabolic evolution
WO2013053883A1 (en) 2011-10-12 2013-04-18 Eviagenics S.A. Method of generating gene mosaics in eukaryotic cells
EP2749644B1 (de) 2012-12-27 2018-08-22 Rhodia Operations Rekombinante Wirtszelle zur biosynthetischen Herstellung von Vanillin
CN105283547B (zh) 2012-12-27 2022-10-04 罗地亚经营管理公司 用于生物合成生产的重组宿主细胞
CN105378060B (zh) 2013-03-13 2019-12-10 经纬生物科技有限公司 非复制型转导颗粒和基于转导颗粒的报告系统
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

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US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3724625A1 (de) * 1987-07-24 1989-02-02 Boehringer Mannheim Gmbh Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine

Also Published As

Publication number Publication date
EP0449923B1 (de) 1995-09-06
FR2641793B1 (fr) 1993-10-01
US5965415A (en) 1999-10-12
IE894182L (en) 1990-06-26
JPH04503601A (ja) 1992-07-02
ATE127519T1 (de) 1995-09-15
IL92856A0 (en) 1990-09-17
WO1990007576A1 (fr) 1990-07-12
DE68924174D1 (de) 1995-10-12
AU4834390A (en) 1990-08-01
EP0449923A1 (de) 1991-10-09
US5912119A (en) 1999-06-15
IE72469B1 (en) 1997-04-09
FR2641793A1 (fr) 1990-07-20
ES2077058T3 (es) 1995-11-16
JP3056524B2 (ja) 2000-06-26
ZA899902B (en) 1990-09-26
CA2006549C (fr) 2000-09-05
CA2006549A1 (fr) 1990-06-26
DE68924174T2 (de) 1996-03-14

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