ZA899902B - Process for the in vivo recombination of partially homologous dna sequences - Google Patents

Process for the in vivo recombination of partially homologous dna sequences

Info

Publication number
ZA899902B
ZA899902B ZA899902A ZA899902A ZA899902B ZA 899902 B ZA899902 B ZA 899902B ZA 899902 A ZA899902 A ZA 899902A ZA 899902 A ZA899902 A ZA 899902A ZA 899902 B ZA899902 B ZA 899902B
Authority
ZA
South Africa
Prior art keywords
dna sequences
homologous dna
partially homologous
recombination
vivo recombination
Prior art date
Application number
ZA899902A
Other languages
English (en)
Inventor
Miroslav Radman
Radman Miroslav
Christiane Rayssiguier
Rayssiguier Christiane
Original Assignee
Setratech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setratech filed Critical Setratech
Publication of ZA899902B publication Critical patent/ZA899902B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA899902A 1988-12-26 1989-12-27 Process for the in vivo recombination of partially homologous dna sequences ZA899902B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817185A FR2641793B1 (fr) 1988-12-26 1988-12-26 Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases

Publications (1)

Publication Number Publication Date
ZA899902B true ZA899902B (en) 1990-09-26

Family

ID=9373422

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899902A ZA899902B (en) 1988-12-26 1989-12-27 Process for the in vivo recombination of partially homologous dna sequences

Country Status (13)

Country Link
US (2) US5912119A (xx)
EP (1) EP0449923B1 (xx)
JP (1) JP3056524B2 (xx)
AT (1) ATE127519T1 (xx)
AU (1) AU4834390A (xx)
CA (1) CA2006549C (xx)
DE (1) DE68924174T2 (xx)
ES (1) ES2077058T3 (xx)
FR (1) FR2641793B1 (xx)
IE (1) IE72469B1 (xx)
IL (1) IL92856A (xx)
WO (1) WO1990007576A1 (xx)
ZA (1) ZA899902B (xx)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
EP0842289B1 (en) * 1995-07-26 2004-10-20 Mixis France S.A. Homologous recombination in mismatch repair inactivated eukaryotic cells
US6489145B1 (en) * 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6165718A (en) 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
ATE293684T1 (de) * 1996-01-10 2005-05-15 Novozymes As Methode zur invivo produktion einer mutanten- bibliothek in zellen
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
WO1997037011A1 (en) * 1996-04-01 1997-10-09 Setratech S.A.R.L. Meiotic recombination in vivo of partially homologous dna sequences
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
CN1208456C (zh) * 1996-12-20 2005-06-29 诺维信公司 体内重组
US6265201B1 (en) 1997-01-17 2001-07-24 Regents Of The University Of Minnesota DNA molecules and protein displaying improved triazine compound degrading ability
DE69835360T2 (de) 1997-01-17 2007-08-16 Maxygen, Inc., Redwood City EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
AUPO974597A0 (en) * 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
IL136574A0 (en) 1997-12-08 2001-06-14 California Inst Of Techn A method for forming a polynucleotide of desired properties
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) * 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) * 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
AU2415200A (en) * 1999-01-18 2000-08-01 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
EP1072010B1 (en) 1999-01-19 2010-04-21 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US6518042B1 (en) * 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
AU2536400A (en) * 1999-02-24 2000-09-14 Novozymes A/S Fungal cells with inactivated dna mismatch repair system
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
CA2422487A1 (en) * 2000-09-18 2002-03-28 Pioneer Hi-Bred International, Inc. Rice mlh1 ortholog and uses thereof
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7638334B2 (en) * 2002-01-18 2009-12-29 Morphotek, Inc. Method for generating engineered cells by homologously recombining segments having increased degeneracy
PT1333095E (pt) * 2002-01-31 2006-07-31 Mixis France Sa Processo para a inactivacao funcional reversivel do sistema de reparacao de falso emparelhamento
IL164687A0 (en) * 2002-05-02 2005-12-18 Univ North Carolina Cellular libraries and methods for the preparationthereof
AU2005259411A1 (en) * 2004-07-06 2006-01-12 Mixis France S.A. Generation of recombinant genes in bacteriophages
EP1734125A1 (en) * 2005-06-16 2006-12-20 Institut National De La Recherche Agronomique Homeologous recombination in MSH2 inactivated plants or cells thereof
US20080124355A1 (en) * 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2010111686A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Labeled enzyme compositions, methods & systems
EP2478100B1 (en) 2010-04-09 2013-11-13 Eviagenics S.A. Method of generating gene mosaics
DK2677881T3 (da) 2011-02-24 2020-07-13 Erber Ag Enzymer til behandling af foder
AU2012274098A1 (en) 2011-06-21 2014-01-09 Eviagenics S.A. Method of metabolic evolution
US20140274803A1 (en) 2011-10-12 2014-09-18 Eviagenics S.A. Method of generating gene mosaics in eukaryotic cells
BR112015015594B1 (pt) 2012-12-27 2022-07-05 Rhodia Operations Célula de levedura, método de produção de uma célula de levedura, uso de uma célula de levedura e método de biossíntese heteróloga de um valinoide
EP2749644B1 (en) 2012-12-27 2018-08-22 Rhodia Operations Recombinant host cell for biosynthetic production of vanillin
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
BR112015023108A8 (pt) 2013-03-13 2018-01-23 Geneweave Biosciences Inc sistema de acondicionamento de célula bacteriana, método para acondicionamento de uma molécula de ácido nucléico repórter, composição, método para detectar uma presença ou uma ausência de uma célula bacteriana em uma amostra, vetor, método para detectar um transcrito alvo em uma célula, método para detectar a presença de uma célula bacteriana em uma amostra e kit.
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3724625A1 (de) * 1987-07-24 1989-02-02 Boehringer Mannheim Gmbh Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine

Also Published As

Publication number Publication date
US5965415A (en) 1999-10-12
US5912119A (en) 1999-06-15
JPH04503601A (ja) 1992-07-02
EP0449923B1 (fr) 1995-09-06
IE894182L (en) 1990-06-26
AU4834390A (en) 1990-08-01
ES2077058T3 (es) 1995-11-16
IE72469B1 (en) 1997-04-09
FR2641793A1 (fr) 1990-07-20
FR2641793B1 (fr) 1993-10-01
IL92856A0 (en) 1990-09-17
JP3056524B2 (ja) 2000-06-26
EP0449923A1 (fr) 1991-10-09
IL92856A (en) 2001-04-30
DE68924174T2 (de) 1996-03-14
ATE127519T1 (de) 1995-09-15
CA2006549C (fr) 2000-09-05
WO1990007576A1 (fr) 1990-07-12
DE68924174D1 (de) 1995-10-12
CA2006549A1 (fr) 1990-06-26

Similar Documents

Publication Publication Date Title
ZA899902B (en) Process for the in vivo recombination of partially homologous dna sequences
ATE93537T1 (de) Astaxantin liefernde hefezellen, verfahren zur herstellung.
HUT52105A (en) Process for producing phosphorous l-amino acids, as well as esters and n-derivatives thereof
ATE107362T1 (de) Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns.
YU81585A (en) Process for preparation of substituted phosphatidylholynes and phosphatidyl ethanolamines
ATE106451T1 (de) Fermentationsverfahren zur herstellung von 2-keto-l-gulonsäure.
AU570572B2 (en) 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl) amino)-3- furancarboxylic acid derivatives
HUT45564A (en) Process for producing hirudine variants
ATE95836T1 (de) Zum abbau von glycosaminoglycan faehige enzymzusammensetzung und verfahren zur herstellung dieser zusammensetzung.
HU895788D0 (en) Process for producing peptides and medical products containing them
HUT45035A (en) Process for producing thiazolone derivatives
HUT46662A (en) Process for producing alkyl-melatonins
EP0712928A3 (xx)
AU591305B2 (en) Improved process for preparing 5,6-substitued-2,4- quinazolinediamines and novel intermediates
EP0273268A3 (en) Reduced-stability alpha-amylase and process for its production
AU3906389A (en) An improved process for the conversion of natural gas into middle distillates
ATE295886T1 (de) Photometrischer test zur bestimmung von pyrophosphat nach dessen enzymatischer umsetzung
GR3006677T3 (xx)
DK0853127T3 (da) Biotin-biosyntese-gener II
MY102317A (en) Novel microorganisms and a method for production of glutamic acid using the same.
CA2027059A1 (en) Process for the preparation of l-serine by an enzymatic method
ATE46316T1 (de) 3-hydroxydicarbonsaeuren und ein verfahren zu ihrer herstellung.
IL101256A0 (en) Microbiological process for producing 6-hydroxypicolinic acid
ES8607390A1 (es) Metodo de detectar acidos nucleicos.
UA7130A1 (uk) Імуностимулюючий засіб "тімоген"