ATE127519T1 - Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen. - Google Patents

Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen.

Info

Publication number
ATE127519T1
ATE127519T1 AT90900900T AT90900900T ATE127519T1 AT E127519 T1 ATE127519 T1 AT E127519T1 AT 90900900 T AT90900900 T AT 90900900T AT 90900900 T AT90900900 T AT 90900900T AT E127519 T1 ATE127519 T1 AT E127519T1
Authority
AT
Austria
Prior art keywords
recombination
dna sequences
vivo
homologous dna
partially homologous
Prior art date
Application number
AT90900900T
Other languages
English (en)
Inventor
Miroslav Cnrs Radman
Christiane Rayssiguier
Original Assignee
Setratech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setratech filed Critical Setratech
Application granted granted Critical
Publication of ATE127519T1 publication Critical patent/ATE127519T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90900900T 1988-12-26 1989-12-22 Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen. ATE127519T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817185A FR2641793B1 (fr) 1988-12-26 1988-12-26 Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases

Publications (1)

Publication Number Publication Date
ATE127519T1 true ATE127519T1 (de) 1995-09-15

Family

ID=9373422

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900900T ATE127519T1 (de) 1988-12-26 1989-12-22 Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen.

Country Status (13)

Country Link
US (2) US5912119A (de)
EP (1) EP0449923B1 (de)
JP (1) JP3056524B2 (de)
AT (1) ATE127519T1 (de)
AU (1) AU4834390A (de)
CA (1) CA2006549C (de)
DE (1) DE68924174T2 (de)
ES (1) ES2077058T3 (de)
FR (1) FR2641793B1 (de)
IE (1) IE72469B1 (de)
IL (1) IL92856A (de)
WO (1) WO1990007576A1 (de)
ZA (1) ZA899902B (de)

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US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
ATE280239T1 (de) * 1995-07-26 2004-11-15 Mixis France Sa Homologe rekombination in eukaryotischen zellen mit inaktiviertem fehlpaarungsreparatur-system
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6489145B1 (en) * 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
EP0873398B1 (de) * 1996-01-10 2005-04-20 Novozymes A/S Methode zur invivo produktion einer mutanten-bibliothek in zellen
US6165718A (en) 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
WO1997037011A1 (en) * 1996-04-01 1997-10-09 Setratech S.A.R.L. Meiotic recombination in vivo of partially homologous dna sequences
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
EP0948615B1 (de) * 1996-12-20 2004-12-15 Novozymes A/S In vivo rekombination
DE69835360T2 (de) 1997-01-17 2007-08-16 Maxygen, Inc., Redwood City EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU6029998A (en) 1997-01-17 1998-08-07 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
DK2270234T3 (da) 1997-12-08 2013-06-03 California Inst Of Techn Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) * 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
WO2000042559A1 (en) * 1999-01-18 2000-07-20 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
IL138002A0 (en) 1999-01-19 2001-10-31 Maxygen Inc Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US6518042B1 (en) * 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
JP2002536990A (ja) * 1999-02-24 2002-11-05 ノボザイムス アクティーゼルスカブ 不活性化されたｄｎａミスマッチ修復系を有する菌類細胞
US7430477B2 (en) * 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
CA2422487A1 (en) * 2000-09-18 2002-03-28 Pioneer Hi-Bred International, Inc. Rice mlh1 ortholog and uses thereof
EP1354064A2 (de) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen
CA2473741C (en) * 2002-01-18 2015-12-22 Morphotek, Inc. A method for generating engineered cells for locus specific gene regulation and analysis
EP1333095B1 (de) * 2002-01-31 2006-03-08 Mixis France S.A. Methode zur reversiblen funktionellen Inaktivierung des Mismatch Reparatursystems
WO2003093426A2 (en) * 2002-05-02 2003-11-13 University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
NZ551993A (en) * 2004-07-06 2009-12-24 Mixis France Sa Generation of recombinant genes in a bacteriophage and a bacterial host cell.
EP1734125A1 (de) * 2005-06-16 2006-12-20 Institut National De La Recherche Agronomique Homeologische Rekombination in MSH2 inaktivierten Pflanzen oder deren Zellen
US20080124355A1 (en) * 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US8603792B2 (en) 2009-03-27 2013-12-10 Life Technologies Corporation Conjugates of biomolecules to nanoparticles
PT2478100E (pt) 2010-04-09 2014-02-20 Eviagenics S A Método de geração de mosaicos de genes
WO2012113827A1 (en) 2011-02-24 2012-08-30 Eucodis Bioscience Gmbh Feed processing enzymes
EP2723860A1 (de) 2011-06-21 2014-04-30 Eviagenics S.A. Verfahren für stoffwechselevolution
CN104105793A (zh) 2011-10-12 2014-10-15 埃微杰尼克斯有限公司 在真核细胞中产生基因嵌合体的方法
US10519472B2 (en) 2012-12-27 2019-12-31 Rhodia Operations Recombinant host cell for biosynthetic production
EP2749644B1 (de) 2012-12-27 2018-08-22 Rhodia Operations Rekombinante Wirtszelle zur biosynthetischen Herstellung von Vanillin
JP6431035B2 (ja) 2013-03-13 2018-11-28 ジーンウィーブ バイオサイエンシズ，インコーポレイティド 非複製的形質導入粒子及び形質導入粒子に基づくレポーターシステム
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

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US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3724625A1 (de) * 1987-07-24 1989-02-02 Boehringer Mannheim Gmbh Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine

Also Published As

Publication number Publication date
FR2641793B1 (fr) 1993-10-01
DE68924174T2 (de) 1996-03-14
AU4834390A (en) 1990-08-01
CA2006549C (fr) 2000-09-05
CA2006549A1 (fr) 1990-06-26
ZA899902B (en) 1990-09-26
EP0449923B1 (de) 1995-09-06
JP3056524B2 (ja) 2000-06-26
US5965415A (en) 1999-10-12
JPH04503601A (ja) 1992-07-02
IL92856A0 (en) 1990-09-17
EP0449923A1 (de) 1991-10-09
IE72469B1 (en) 1997-04-09
IE894182L (en) 1990-06-26
WO1990007576A1 (fr) 1990-07-12
ES2077058T3 (es) 1995-11-16
US5912119A (en) 1999-06-15
DE68924174D1 (de) 1995-10-12
FR2641793A1 (fr) 1990-07-20
IL92856A (en) 2001-04-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
EELA Cancelled due to lapse of time