ATE127519T1 - Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen. - Google Patents

Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen.

Info

Publication number
ATE127519T1
ATE127519T1 AT90900900T AT90900900T ATE127519T1 AT E127519 T1 ATE127519 T1 AT E127519T1 AT 90900900 T AT90900900 T AT 90900900T AT 90900900 T AT90900900 T AT 90900900T AT E127519 T1 ATE127519 T1 AT E127519T1
Authority
AT
Austria
Prior art keywords
recombination
dna sequences
vivo
homologous dna
partially homologous
Prior art date
Application number
AT90900900T
Other languages
English (en)
Inventor
Miroslav Cnrs Radman
Christiane Rayssiguier
Original Assignee
Setratech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setratech filed Critical Setratech
Application granted granted Critical
Publication of ATE127519T1 publication Critical patent/ATE127519T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT90900900T 1988-12-26 1989-12-22 Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen. ATE127519T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817185A FR2641793B1 (fr) 1988-12-26 1988-12-26 Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases

Publications (1)

Publication Number Publication Date
ATE127519T1 true ATE127519T1 (de) 1995-09-15

Family

ID=9373422

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90900900T ATE127519T1 (de) 1988-12-26 1989-12-22 Verfahren zur rekombination in vivo von teilweise homologen dns-sequenzen.

Country Status (13)

Country Link
US (2) US5912119A (de)
EP (1) EP0449923B1 (de)
JP (1) JP3056524B2 (de)
AT (1) ATE127519T1 (de)
AU (1) AU4834390A (de)
CA (1) CA2006549C (de)
DE (1) DE68924174T2 (de)
ES (1) ES2077058T3 (de)
FR (1) FR2641793B1 (de)
IE (1) IE72469B1 (de)
IL (1) IL92856A (de)
WO (1) WO1990007576A1 (de)
ZA (1) ZA899902B (de)

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US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
CA2263958C (en) * 1995-07-26 2012-06-19 Mixis France Homologous recombination in mismatch repair inactivated eukaryotic cells
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6489145B1 (en) * 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
US6165718A (en) 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
AU1367897A (en) * 1996-01-10 1997-08-01 Novo Nordisk A/S A method for in vivo production of a mutant library in cells
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US7115413B2 (en) 1996-04-01 2006-10-03 Mixis France S.A. Meiotic recombination in vivo of partially homologous DNA sequences
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
EP0948615B1 (de) * 1996-12-20 2004-12-15 Novozymes A/S In vivo rekombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU743305C (en) 1997-01-17 2006-03-30 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
WO1998031816A1 (en) 1997-01-17 1998-07-23 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
EP1036198B1 (de) 1997-12-08 2012-09-26 California Institute Of Technology Verfahren zur Herstellung von Polynukleotid- und Polypeptidsequenzen
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) * 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
WO2000042559A1 (en) * 1999-01-18 2000-07-20 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
EP1130093A1 (de) 1999-01-19 2001-09-05 Maxygen, Inc. Oligonukleotiden-gesteuerte Nukleinsäurenrekombination
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
CN1341146A (zh) * 1999-02-24 2002-03-20 诺维信公司 具有灭活的dna错配修复系统的真菌细胞
US6518042B1 (en) 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
US7430477B2 (en) * 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US20020088021A1 (en) * 2000-09-18 2002-07-04 Mahajan Pramod B. Rice MLH1 ortholog and uses thereof
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
EP1474522B1 (de) * 2002-01-18 2012-03-07 Morphotek, Inc. Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
EP1333095B1 (de) * 2002-01-31 2006-03-08 Mixis France S.A. Methode zur reversiblen funktionellen Inaktivierung des Mismatch Reparatursystems
WO2003093426A2 (en) * 2002-05-02 2003-11-13 University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
MX2007000037A (es) * 2004-07-06 2007-03-27 Mixis France Sa Generacion de genes recombinantes en bacterifagos.
EP1734125A1 (de) * 2005-06-16 2006-12-20 Institut National De La Recherche Agronomique Homeologische Rekombination in MSH2 inaktivierten Pflanzen oder deren Zellen
US20080124355A1 (en) * 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2010111691A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Conjugates of biomolecules to nanoparticles
CN102933710A (zh) 2010-04-09 2013-02-13 艾威艾基克斯有限公司 产生基因嵌合体的方法
EP2677881B1 (de) 2011-02-24 2020-04-01 Erber Aktiengesellschaft Enzyme zur futtermittel behandlung
JP2014519831A (ja) 2011-06-21 2014-08-21 エヴィアジェニクス ソシエテ・アノニム 代謝的進化の方法
CN104105793A (zh) 2011-10-12 2014-10-15 埃微杰尼克斯有限公司 在真核细胞中产生基因嵌合体的方法
BR112015015594B1 (pt) 2012-12-27 2022-07-05 Rhodia Operations Célula de levedura, método de produção de uma célula de levedura, uso de uma célula de levedura e método de biossíntese heteróloga de um valinoide
EP2749644B1 (de) 2012-12-27 2018-08-22 Rhodia Operations Rekombinante Wirtszelle zur biosynthetischen Herstellung von Vanillin
EP3699592A1 (de) 2013-03-13 2020-08-26 Geneweave Biosciences Inc. Nichtreplikative transduktionspartikel und auf transduktionspartikeln basierende reportersysteme
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
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US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

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US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3724625A1 (de) * 1987-07-24 1989-02-02 Boehringer Mannheim Gmbh Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine

Also Published As

Publication number Publication date
DE68924174T2 (de) 1996-03-14
US5912119A (en) 1999-06-15
CA2006549C (fr) 2000-09-05
IL92856A (en) 2001-04-30
IL92856A0 (en) 1990-09-17
ZA899902B (en) 1990-09-26
FR2641793A1 (fr) 1990-07-20
WO1990007576A1 (fr) 1990-07-12
IE72469B1 (en) 1997-04-09
ES2077058T3 (es) 1995-11-16
EP0449923A1 (de) 1991-10-09
IE894182L (en) 1990-06-26
DE68924174D1 (de) 1995-10-12
CA2006549A1 (fr) 1990-06-26
EP0449923B1 (de) 1995-09-06
AU4834390A (en) 1990-08-01
JPH04503601A (ja) 1992-07-02
US5965415A (en) 1999-10-12
FR2641793B1 (fr) 1993-10-01
JP3056524B2 (ja) 2000-06-26

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Legal Events

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UEP Publication of translation of european patent specification
EEFA Change of the company name
EELA Cancelled due to lapse of time