DE3587519D1 - Verfahren zur herstellung von l-aminosaeuren. - Google Patents

Verfahren zur herstellung von l-aminosaeuren.

Info

Publication number
DE3587519D1
DE3587519D1 DE8585112621T DE3587519T DE3587519D1 DE 3587519 D1 DE3587519 D1 DE 3587519D1 DE 8585112621 T DE8585112621 T DE 8585112621T DE 3587519 T DE3587519 T DE 3587519T DE 3587519 D1 DE3587519 D1 DE 3587519D1
Authority
DE
Germany
Prior art keywords
producing
amino acids
acids
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585112621T
Other languages
English (en)
Other versions
DE3587519T2 (de
Inventor
Konosuke Sano
Chieko Oosumi
Kazuhiko Matsui
Kiyoshi Miwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE3587519D1 publication Critical patent/DE3587519D1/de
Application granted granted Critical
Publication of DE3587519T2 publication Critical patent/DE3587519T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/84—Brevibacterium

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE85112621T 1984-10-04 1985-10-04 Verfahren zur Herstellung von L-Aminosäuren. Expired - Lifetime DE3587519T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59208677A JPH0746994B2 (ja) 1984-10-04 1984-10-04 発酵法によるｌ−アミノ酸の製造法

Publications (2)

Publication Number Publication Date
DE3587519D1 true DE3587519D1 (de) 1993-09-16
DE3587519T2 DE3587519T2 (de) 1994-04-07

Family

ID=16560229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE85112621T Expired - Lifetime DE3587519T2 (de) 1984-10-04 1985-10-04 Verfahren zur Herstellung von L-Aminosäuren.

Country Status (4)

Country Link
US (1) US4980285A (de)
EP (1) EP0179338B1 (de)
JP (1) JPH0746994B2 (de)
DE (1) DE3587519T2 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6255089A (ja) * 1985-05-10 1987-03-10 Asahi Chem Ind Co Ltd ホスホエノ−ルピルビン酸カルボキシラ−ゼ産生遺伝子を含むｄｎａ断片
EP0204326B1 (de) * 1985-06-05 1992-03-25 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur Herstellung von L-Threonin und L-Isoleucin
JPS62186795A (ja) * 1986-02-12 1987-08-15 Kyowa Hakko Kogyo Co Ltd アミノ酸の製造法
US6649379B1 (en) 1987-06-12 2003-11-18 Massachusetts Institute Of Technology Method and deregulated enzyme for threonine production
WO1988009819A2 (en) * 1987-06-12 1988-12-15 Massachusetts Institute Of Technology C. glutamicum threonine biosynthetic pathway
US5185262A (en) * 1988-07-27 1993-02-09 Mitsubishi Petrochemical Co., Ltd. DNA fragment containing gene which encodes the function of stabilizing plasmid in host microorganism
JP2748418B2 (ja) * 1988-08-03 1998-05-06 味の素株式会社 組換えｄｎａ、該組換えｄｎａを有する微生物
GB2223754B (en) * 1988-09-12 1992-07-22 Degussa Dna encoding phosphoenolpyruvate carboxylase
JP2990735B2 (ja) * 1990-04-20 1999-12-13 味の素株式会社 Ｌ―リジンの発酵的製造法
US5776736A (en) * 1992-12-21 1998-07-07 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
JPH07155184A (ja) * 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
MY113040A (en) * 1994-02-24 2001-11-30 Ajinomoto Kk Novel gene derived from coryneform bacteria and use thereof
DE69534592T2 (de) * 1994-03-04 2006-08-10 Ajinomoto Co., Inc. Verfahren für die herstellung von l-lysin
ES2160167T3 (es) * 1994-06-14 2001-11-01 Ajinomoto Kk Gen de alfa-cetoglutarato-deshidrogenasa.
CN1117860C (zh) * 1995-06-13 2003-08-13 味之素株式会社 发酵生产l－赖氨酸的方法
JP4035855B2 (ja) * 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
US5939307A (en) * 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
AU756507B2 (en) * 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
RU2175351C2 (ru) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
DE19907567B4 (de) * 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
US6451564B1 (en) 1999-07-02 2002-09-17 Massachusetts Institute Of Technology Methods for producing L-isoleucine
US6927046B1 (en) 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
US7220571B2 (en) 2000-09-28 2007-05-22 Archer-Daniels-Midland Company Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation
RU2244007C2 (ru) * 2002-02-27 2005-01-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-треонина, штамм escherichia coli - продуцент треонина (варианты)
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
US20050255568A1 (en) * 2003-05-30 2005-11-17 Bailey Richard B Methods and compositions for amino acid production
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
JP5432524B2 (ja) * 2005-06-20 2014-03-05 アーチャー−ダニエルズ−ミッドランド カンパニー アスパラギン酸由来アミノ酸および化学物質の改善された生産のための改変グリオキシル酸シャント
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
US20090098529A1 (en) 2006-10-16 2009-04-16 Nanhai Chen Methods for attenuating virus strains for diagnostic and therapeutic uses
US20090117034A1 (en) * 2007-06-15 2009-05-07 Nanhai Chen Microorganisms for imaging and/or treatment of tumors
DE102010029973A1 (de) 2010-06-11 2011-12-15 Evonik Degussa Gmbh Mikrobiologische Herstellung von C4-Körpern aus Saccharose und Kohlendioxid
US20140087362A1 (en) 2012-03-16 2014-03-27 Aladar A. Szalay Methods for assessing effectiveness and monitoring oncolytic virus treatment
US20130280170A1 (en) 2012-04-20 2013-10-24 Aladar A. Szalay Imaging methods for oncolytic virus therapy
US10167490B2 (en) 2012-12-21 2019-01-01 Ergo Health Llc Ergothioneine production through metabolic engineering
US9937231B2 (en) 2013-03-27 2018-04-10 The General Hospital Corporation Methods and agents for treating Alzheimer's disease
EP3083658B1 (de) 2013-12-18 2019-05-08 President and Fellows of Harvard College Detektion gram-positiver bakterien mit crp
US10435457B2 (en) 2015-08-06 2019-10-08 President And Fellows Of Harvard College Microbe-binding molecules and uses thereof
TW201825674A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現雙特異性接合分子的溶瘤病毒
CA3040626A1 (en) 2017-04-05 2018-10-11 Centro De Neurociencias E Biologia Celular Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
EP3385373A1 (de) 2017-04-05 2018-10-10 Centro de Neurociências e Biologia Celular Zusammensetzungen zur umprogrammierung von zellen in dendritischen zellen oder antigen-präsentierende zellen, verfahren und verwendungen davon
CN112538491B (zh) * 2020-12-28 2022-12-06 宁夏伊品生物科技股份有限公司 一种基于yh66_08550基因的产l-异亮氨酸的重组菌株及其构建方法与应用
WO2022161355A1 (en) 2021-01-26 2022-08-04 Cytocares (Shanghai) Inc. Chimeric antigen receptor (car) constructs and nk cells expressing car constructs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3909353A (en) * 1973-03-12 1975-09-30 Ajinomoto Kk Method of producing L-phenylalanine by fermentation
US4371614A (en) * 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
JPS57183799A (en) * 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
JPS58126789A (ja) * 1981-12-29 1983-07-28 Kyowa Hakko Kogyo Co Ltd レースレオニンの製造法
JPS59192088A (ja) * 1982-09-29 1984-10-31 Hikari Kimura 遺伝子組換えで造成されるプラスミド
JPS59156292A (ja) * 1983-02-17 1984-09-05 Kyowa Hakko Kogyo Co Ltd トリプトフアンの製造法
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
JPH0783714B2 (ja) * 1983-08-29 1995-09-13 味の素株式会社 発酵法によるｌ―アミノ酸の製造法
JPS6062982A (ja) * 1983-09-14 1985-04-11 Ajinomoto Co Inc 組換えｄνａ，該組換えｄνａを有する細菌及び該細菌を用いるｌ−スレオニン又はｌ−イソロイシンの製造法
EP0204326B1 (de) * 1985-06-05 1992-03-25 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur Herstellung von L-Threonin und L-Isoleucin
WO1987001130A1 (en) * 1985-08-15 1987-02-26 Stauffer Chemical Company Tryptophan producing microorganism

Also Published As

Publication number Publication date
US4980285A (en) 1990-12-25
EP0179338B1 (de) 1993-08-11
EP0179338A2 (de) 1986-04-30
EP0179338A3 (en) 1987-11-19
JPH0746994B2 (ja) 1995-05-24
DE3587519T2 (de) 1994-04-07
JPS6188889A (ja) 1986-05-07

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