IL91952A - Piperidinyl benzimidazoles, their preparation and pharmaceutical preparations containing them - Google Patents

Piperidinyl benzimidazoles, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL91952A
IL91952A IL9195289A IL9195289A IL91952A IL 91952 A IL91952 A IL 91952A IL 9195289 A IL9195289 A IL 9195289A IL 9195289 A IL9195289 A IL 9195289A IL 91952 A IL91952 A IL 91952A
Authority
IL
Israel
Prior art keywords
formula
represented
piperidinyl
benzimidazole
derivative
Prior art date
Application number
IL9195289A
Other languages
English (en)
Hebrew (he)
Other versions
IL91952A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL91952A0 publication Critical patent/IL91952A0/xx
Publication of IL91952A publication Critical patent/IL91952A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)
IL9195289A 1988-10-13 1989-10-11 Piperidinyl benzimidazoles, their preparation and pharmaceutical preparations containing them IL91952A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/256,959 US4908372A (en) 1988-10-13 1988-10-13 Antihistaminic piperidinyl benzimidazoles

Publications (2)

Publication Number Publication Date
IL91952A0 IL91952A0 (en) 1990-06-10
IL91952A true IL91952A (en) 1994-06-24

Family

ID=22974308

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9195289A IL91952A (en) 1988-10-13 1989-10-11 Piperidinyl benzimidazoles, their preparation and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US4908372A (es)
EP (1) EP0363963B1 (es)
JP (1) JP2867151B2 (es)
KR (1) KR0157046B1 (es)
CN (1) CN1028103C (es)
AR (1) AR248018A1 (es)
AT (1) ATE121741T1 (es)
AU (1) AU619601B2 (es)
CA (1) CA2000468C (es)
DE (1) DE68922366T2 (es)
DK (1) DK506189A (es)
ES (1) ES2074067T3 (es)
FI (1) FI894834A0 (es)
HU (1) HU203340B (es)
IE (1) IE66112B1 (es)
IL (1) IL91952A (es)
NO (1) NO894086L (es)
NZ (1) NZ230956A (es)
PT (1) PT91968B (es)
ZA (1) ZA897676B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds
WO1992006086A1 (en) * 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
JP3112290B2 (ja) * 1990-12-14 2000-11-27 メレルダウファーマスーティカルズ インコーポレイテッド 抗アレルギー化合物
TW263504B (es) * 1991-10-03 1995-11-21 Pfizer
WO1993014083A1 (en) * 1992-01-09 1993-07-22 Janssen Pharmaceutica N.V. Pharmaceutically active substituted benzimidazole derivatives
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
CN1067385C (zh) 1994-08-25 2001-06-20 默里尔药物公司 用于治疗变应性疾病的新的取代的哌啶类化合物
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
JP2000507269A (ja) * 1996-03-15 2000-06-13 イーライ・リリー・アンド・カンパニー 一般かぜまたはアレルギー性鼻炎の処置方法
ES2291293T3 (es) * 2000-02-29 2008-03-01 Mitsubishi Pharma Corporation Nuevos derivados amida ciclicos.
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
CN101072561B (zh) * 2004-10-07 2011-05-11 生命医药公司 二氨基烷烃天冬氨酸蛋白酶抑制剂
CA2628570A1 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
TWI411607B (zh) * 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
JP2010503682A (ja) * 2006-09-18 2010-02-04 ビテ ファーマシューティカルズ， インコーポレイテッド レニン阻害剤としてのピペリジン誘導体
CL2007002689A1 (es) * 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
US20100160424A1 (en) * 2007-06-20 2010-06-24 Baldwin John J Renin inhibitors
WO2009096996A1 (en) * 2007-06-20 2009-08-06 Smithkline Beecham Corporation Renin inhibitors
US20110160300A1 (en) * 2008-06-20 2011-06-30 Marlys Hammond Renin Inhibitors and Methods of Use Thereof
WO2009158377A1 (en) * 2008-06-26 2009-12-30 Smith Kline Beecham Corporation Salts of methyl 2-((r))-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3((r)-tetrahydro-2h-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
AR077692A1 (es) * 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2447263A1 (en) * 2010-09-27 2012-05-02 Bioprojet Benzazole derivatives as histamine H4 receptor ligands
CN104428293B (zh) 2012-06-11 2018-06-08 Ucb生物制药私人有限公司 调节TNFα的苯并咪唑类
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds

Also Published As

Publication number Publication date
HU895305D0 (en) 1990-01-28
IE66112B1 (en) 1995-12-13
NZ230956A (en) 1991-03-26
CA2000468A1 (en) 1990-04-13
IL91952A0 (en) 1990-06-10
NO894086D0 (no) 1989-10-12
ES2074067T3 (es) 1995-09-01
KR0157046B1 (ko) 1998-11-16
US4908372A (en) 1990-03-13
ATE121741T1 (de) 1995-05-15
DE68922366D1 (de) 1995-06-01
EP0363963A1 (en) 1990-04-18
DK506189D0 (da) 1989-10-12
AU4273589A (en) 1990-04-26
CN1041940A (zh) 1990-05-09
ZA897676B (en) 1990-07-25
HUT51613A (en) 1990-05-28
JPH02134377A (ja) 1990-05-23
HU203340B (en) 1991-07-29
CN1028103C (zh) 1995-04-05
KR900006318A (ko) 1990-05-07
JP2867151B2 (ja) 1999-03-08
AU619601B2 (en) 1992-01-30
AR248018A1 (es) 1995-05-31
NO894086L (no) 1990-04-17
PT91968A (pt) 1990-04-30
IE893294L (en) 1990-04-13
FI894834A0 (fi) 1989-10-12
EP0363963B1 (en) 1995-04-26
DK506189A (da) 1990-04-14
CA2000468C (en) 2000-03-21
PT91968B (pt) 1995-05-31
DE68922366T2 (de) 1995-09-28

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Legal Events

Date Code Title Description
KB Patent renewed
RH1 Patent not in force
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.