DE68922366T2 - Piperidinyl-Benzimidazole als Antihistaminica. - Google Patents
Piperidinyl-Benzimidazole als Antihistaminica.Info
- Publication number
- DE68922366T2 DE68922366T2 DE68922366T DE68922366T DE68922366T2 DE 68922366 T2 DE68922366 T2 DE 68922366T2 DE 68922366 T DE68922366 T DE 68922366T DE 68922366 T DE68922366 T DE 68922366T DE 68922366 T2 DE68922366 T2 DE 68922366T2
- Authority
- DE
- Germany
- Prior art keywords
- benzimidazoles
- antihistamines
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/256,959 US4908372A (en) | 1988-10-13 | 1988-10-13 | Antihistaminic piperidinyl benzimidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68922366D1 DE68922366D1 (de) | 1995-06-01 |
DE68922366T2 true DE68922366T2 (de) | 1995-09-28 |
Family
ID=22974308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68922366T Expired - Fee Related DE68922366T2 (de) | 1988-10-13 | 1989-10-12 | Piperidinyl-Benzimidazole als Antihistaminica. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4908372A (de) |
EP (1) | EP0363963B1 (de) |
JP (1) | JP2867151B2 (de) |
KR (1) | KR0157046B1 (de) |
CN (1) | CN1028103C (de) |
AR (1) | AR248018A1 (de) |
AT (1) | ATE121741T1 (de) |
AU (1) | AU619601B2 (de) |
CA (1) | CA2000468C (de) |
DE (1) | DE68922366T2 (de) |
DK (1) | DK506189A (de) |
ES (1) | ES2074067T3 (de) |
FI (1) | FI894834A0 (de) |
HU (1) | HU203340B (de) |
IE (1) | IE66112B1 (de) |
IL (1) | IL91952A (de) |
NO (1) | NO894086L (de) |
NZ (1) | NZ230956A (de) |
PT (1) | PT91968B (de) |
ZA (1) | ZA897676B (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2022451C (en) * | 1989-08-03 | 2001-01-23 | Albert Anthony Carr | Anti-psychotic piperidynl benzimidazole compounds |
WO1992006086A1 (en) * | 1990-10-01 | 1992-04-16 | Janssen Pharmaceutica N.V. | Novel 4-piperidinylcarbonyl derivatives |
FR2668150B1 (fr) * | 1990-10-17 | 1994-11-18 | Theramex | Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant. |
CA2097317C (en) * | 1990-12-14 | 2002-02-12 | Albert A. Carr | Antiallergic piperdinyl benzimidazoles |
TW263504B (de) * | 1991-10-03 | 1995-11-21 | Pfizer | |
TW231291B (de) * | 1992-01-09 | 1994-10-01 | Janssen Pharmaceutica Nv | |
PT626968E (pt) * | 1992-02-13 | 2002-03-28 | Merrell Pharma Inc | Derivados de piperidinilo tiaciclicos |
MX9701305A (es) | 1994-08-25 | 1998-05-31 | Merrell Pharma Inc | Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas. |
US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
US5998439A (en) * | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
CN1218368A (zh) * | 1996-03-15 | 1999-06-02 | 伊莱利利公司 | 治疗感冒或过敏性鼻炎的方法 |
RU2257384C2 (ru) * | 2000-02-29 | 2005-07-27 | Мицубиси Фарма Корпорейшн | Новые производные циклического амида |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
JP5067968B2 (ja) * | 2004-10-07 | 2012-11-07 | ビテ ファーマシューティカルズ, インコーポレイテッド | ジアミノアルカンアスパラギン酸プロテアーゼ阻害剤 |
NZ568694A (en) | 2005-11-09 | 2011-09-30 | Zalicus Inc | Method, compositions, and kits for the treatment of medical conditions |
TWI411607B (zh) * | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | 天門冬胺酸蛋白酶抑制劑 |
ATE520690T1 (de) * | 2006-09-18 | 2011-09-15 | Vitae Pharmaceuticals Inc | Piperidinderivate als renin-inhibitoren |
CL2007002689A1 (es) | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
WO2009096996A1 (en) * | 2007-06-20 | 2009-08-06 | Smithkline Beecham Corporation | Renin inhibitors |
US20100160424A1 (en) * | 2007-06-20 | 2010-06-24 | Baldwin John J | Renin inhibitors |
JP2011525488A (ja) * | 2008-06-20 | 2011-09-22 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | レニン阻害剤およびその使用方法 |
CN102088850A (zh) * | 2008-06-26 | 2011-06-08 | 生命医药公司 | 甲基2-((r)-(3-氯苯基)((r)-1-((s)-2-(甲氨基)-3((r)-四氢-2h-吡喃-3-基)丙基氨甲酰基)哌啶-3-基)甲氧基)氨基甲酸乙酯的盐 |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
AR077692A1 (es) * | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
US20110130711A1 (en) * | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
EP2447263A1 (de) * | 2010-09-27 | 2012-05-02 | Bioprojet | Benzazolderivate als Histamin-H4-Rezeptorliganden |
US9550737B2 (en) | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
CA2022451C (en) * | 1989-08-03 | 2001-01-23 | Albert Anthony Carr | Anti-psychotic piperidynl benzimidazole compounds |
-
1988
- 1988-10-13 US US07/256,959 patent/US4908372A/en not_active Expired - Lifetime
-
1989
- 1989-10-09 AR AR89315117A patent/AR248018A1/es active
- 1989-10-09 ZA ZA897676A patent/ZA897676B/xx unknown
- 1989-10-10 AU AU42735/89A patent/AU619601B2/en not_active Ceased
- 1989-10-10 NZ NZ230956A patent/NZ230956A/en unknown
- 1989-10-11 IL IL9195289A patent/IL91952A/en not_active IP Right Cessation
- 1989-10-11 CA CA002000468A patent/CA2000468C/en not_active Expired - Fee Related
- 1989-10-11 KR KR1019890014536A patent/KR0157046B1/ko not_active IP Right Cessation
- 1989-10-12 CN CN89107837A patent/CN1028103C/zh not_active Expired - Fee Related
- 1989-10-12 NO NO89894086A patent/NO894086L/no unknown
- 1989-10-12 IE IE329489A patent/IE66112B1/en not_active IP Right Cessation
- 1989-10-12 FI FI894834A patent/FI894834A0/fi not_active Application Discontinuation
- 1989-10-12 EP EP89118987A patent/EP0363963B1/de not_active Expired - Lifetime
- 1989-10-12 HU HU895305A patent/HU203340B/hu not_active IP Right Cessation
- 1989-10-12 PT PT91968A patent/PT91968B/pt not_active IP Right Cessation
- 1989-10-12 AT AT89118987T patent/ATE121741T1/de not_active IP Right Cessation
- 1989-10-12 DK DK506189A patent/DK506189A/da not_active Application Discontinuation
- 1989-10-12 DE DE68922366T patent/DE68922366T2/de not_active Expired - Fee Related
- 1989-10-12 ES ES89118987T patent/ES2074067T3/es not_active Expired - Lifetime
- 1989-10-13 JP JP1267959A patent/JP2867151B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR900006318A (ko) | 1990-05-07 |
AU4273589A (en) | 1990-04-26 |
AU619601B2 (en) | 1992-01-30 |
CA2000468A1 (en) | 1990-04-13 |
JPH02134377A (ja) | 1990-05-23 |
ZA897676B (en) | 1990-07-25 |
IE893294L (en) | 1990-04-13 |
IL91952A0 (en) | 1990-06-10 |
DK506189A (da) | 1990-04-14 |
KR0157046B1 (ko) | 1998-11-16 |
NZ230956A (en) | 1991-03-26 |
HU895305D0 (en) | 1990-01-28 |
EP0363963A1 (de) | 1990-04-18 |
DE68922366D1 (de) | 1995-06-01 |
FI894834A0 (fi) | 1989-10-12 |
NO894086D0 (no) | 1989-10-12 |
HUT51613A (en) | 1990-05-28 |
ES2074067T3 (es) | 1995-09-01 |
US4908372A (en) | 1990-03-13 |
CN1028103C (zh) | 1995-04-05 |
PT91968A (pt) | 1990-04-30 |
ATE121741T1 (de) | 1995-05-15 |
IL91952A (en) | 1994-06-24 |
AR248018A1 (es) | 1995-05-31 |
NO894086L (no) | 1990-04-17 |
HU203340B (en) | 1991-07-29 |
JP2867151B2 (ja) | 1999-03-08 |
CN1041940A (zh) | 1990-05-09 |
CA2000468C (en) | 2000-03-21 |
PT91968B (pt) | 1995-05-31 |
DK506189D0 (da) | 1989-10-12 |
EP0363963B1 (de) | 1995-04-26 |
IE66112B1 (en) | 1995-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |