IL90973A - Medicinal preparations containing a history of benzapine for the treatment of neurological diseases - Google Patents

Medicinal preparations containing a history of benzapine for the treatment of neurological diseases

Info

Publication number
IL90973A
IL90973A IL9097389A IL9097389A IL90973A IL 90973 A IL90973 A IL 90973A IL 9097389 A IL9097389 A IL 9097389A IL 9097389 A IL9097389 A IL 9097389A IL 90973 A IL90973 A IL 90973A
Authority
IL
Israel
Prior art keywords
hydroxy
hydrogen
hexahydro
azepine
alkyl
Prior art date
Application number
IL9097389A
Other languages
English (en)
Hebrew (he)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL90973A publication Critical patent/IL90973A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9097389A 1988-07-18 1989-07-14 Medicinal preparations containing a history of benzapine for the treatment of neurological diseases IL90973A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/223,739 US4973586A (en) 1986-01-16 1988-07-18 Fused benzazepines, compositions of, and medical use thereof

Publications (1)

Publication Number Publication Date
IL90973A true IL90973A (en) 1994-04-12

Family

ID=22837795

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9097389A IL90973A (en) 1988-07-18 1989-07-14 Medicinal preparations containing a history of benzapine for the treatment of neurological diseases

Country Status (13)

Country Link
US (1) US4973586A (fr)
EP (2) EP0351733B1 (fr)
JP (1) JPH0662420B2 (fr)
KR (1) KR900701275A (fr)
AT (1) ATE131056T1 (fr)
AU (1) AU634973B2 (fr)
CA (1) CA1336823C (fr)
DE (1) DE68925004T2 (fr)
DK (1) DK302190A (fr)
ES (1) ES2080736T3 (fr)
IL (1) IL90973A (fr)
WO (1) WO1990000853A2 (fr)
ZA (1) ZA895343B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
US5091526A (en) * 1988-07-29 1992-02-25 Schering Corporation Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines
CA2016465A1 (fr) * 1989-06-02 1990-12-02 Zola Phillip Horovitz Methode de prevention ou de traitement de l'anxiete par l'emploi d'un bloqueur des canaux calciques
EP0513174B1 (fr) * 1990-02-02 1995-08-16 Schering Corporation Derives de 4,5-cycloalcano-3-benzazepin-7-ol et leurs utilisations
US5312819A (en) * 1990-08-20 1994-05-17 Sandoz Ltd. Pharmaceutical compositions comprising clozapine and a radical scavenger
US5461147A (en) * 1993-09-27 1995-10-24 Schering Corporation Process for preparing benzazepine intermediates for the synthesis of D1 antagonists
US5461148A (en) * 1993-09-27 1995-10-24 Schering Corporation Process for preparing benzazepine intermediates for the synthesis of D1 antagonists
US5463051A (en) * 1993-09-27 1995-10-31 Schering Corporation Process for preparing benzazepine intermediates for the synthesis of D1 antagonists
CA2304592A1 (fr) * 1997-09-24 1999-04-01 The General Hospital Corporation Inhibition de l'etat de besoin induit par les psychostimulants ou la nicotine
US6410527B1 (en) 1998-03-02 2002-06-25 Schering Corporation Method of treating obsessive compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism
US6875866B2 (en) * 2002-02-21 2005-04-05 Schering Corporation Process for synthesis of D1 receptor antagonists
AU2003262926A1 (en) * 2002-08-29 2004-03-19 Schering Corporation Selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders
US7504391B2 (en) * 2003-05-22 2009-03-17 Schering Corporation Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders
LT2872145T (lt) 2012-07-12 2022-06-27 Emalex Biosciences, Inc. Sujungti benzazepinai tureto sindromui gydyti
PL3057595T3 (pl) 2013-10-18 2021-03-08 Emalex Biosciences, Inc. Skondensowane benzazepiny do leczenia jąkania

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
FR2137627A1 (fr) * 1971-05-10 1972-12-29 Hoffmann La Roche
US3983234A (en) * 1974-07-04 1976-09-28 Sandoz Ltd. Treatment of dyskinesias
US3939165A (en) * 1974-11-14 1976-02-17 Morton-Norwich Products, Inc. 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives
US4284555A (en) * 1979-04-27 1981-08-18 Schering Corporation 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4315926A (en) * 1979-12-26 1982-02-16 Ciba-Geigy Corporation Dibenz[c,e]azepines
US4477378A (en) * 1980-02-05 1984-10-16 Schering Corp. Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DE3007710C2 (de) * 1980-02-29 1982-04-15 Gödecke AG, 1000 Berlin 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonin-derivate, Verfahren zu deren Herstellung und Arzneimittel
KR900007781B1 (ko) 1986-01-16 1990-10-20 쉐링 코포레이션 융합된 벤즈아제핀
EP0363353B1 (fr) 1987-07-15 1992-07-22 Schering Corporation Benzazepines fusionnees

Also Published As

Publication number Publication date
US4973586A (en) 1990-11-27
JPH0662420B2 (ja) 1994-08-17
DE68925004T2 (de) 1996-05-15
DK302190D0 (da) 1990-12-20
AU3988489A (en) 1990-02-19
EP0434695A1 (fr) 1991-07-03
ZA895343B (en) 1991-03-27
AU634973B2 (en) 1993-03-11
KR900701275A (ko) 1990-12-01
EP0351733A1 (fr) 1990-01-24
DK302190A (da) 1991-01-11
ES2080736T3 (es) 1996-02-16
EP0351733B1 (fr) 1995-12-06
JPH03502100A (ja) 1991-05-16
WO1990000853A2 (fr) 1990-02-08
ATE131056T1 (de) 1995-12-15
WO1990000853A8 (fr) 2005-06-16
DE68925004D1 (de) 1996-01-18
CA1336823C (fr) 1995-08-29

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Legal Events

Date Code Title Description
RH Patent void