IL86258A - Stabilized hemoglobin, its preparation and a pasteurized blood substitute that prepares it - Google Patents

Stabilized hemoglobin, its preparation and a pasteurized blood substitute that prepares it

Info

Publication number
IL86258A
IL86258A IL8625888A IL8625888A IL86258A IL 86258 A IL86258 A IL 86258A IL 8625888 A IL8625888 A IL 8625888A IL 8625888 A IL8625888 A IL 8625888A IL 86258 A IL86258 A IL 86258A
Authority
IL
Israel
Prior art keywords
hemoglobin
stabilized
hemosafe
tetrameric
product
Prior art date
Application number
IL8625888A
Other languages
English (en)
Hebrew (he)
Other versions
IL86258A0 (en
Original Assignee
Hemosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemosol Inc filed Critical Hemosol Inc
Publication of IL86258A0 publication Critical patent/IL86258A0/xx
Publication of IL86258A publication Critical patent/IL86258A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
IL8625888A 1987-05-05 1988-05-03 Stabilized hemoglobin, its preparation and a pasteurized blood substitute that prepares it IL86258A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878710598A GB8710598D0 (en) 1987-05-05 1987-05-05 Hemoglobin based blood substitute

Publications (2)

Publication Number Publication Date
IL86258A0 IL86258A0 (en) 1988-11-15
IL86258A true IL86258A (en) 1994-11-28

Family

ID=10616838

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8625888A IL86258A (en) 1987-05-05 1988-05-03 Stabilized hemoglobin, its preparation and a pasteurized blood substitute that prepares it

Country Status (15)

Country Link
US (2) US4857636A (ko)
EP (1) EP0290252B1 (ko)
JP (1) JPS63297330A (ko)
KR (1) KR910009343B1 (ko)
CN (1) CN1032471C (ko)
AT (1) ATE84970T1 (ko)
AU (1) AU610883B2 (ko)
CA (1) CA1306583C (ko)
DE (1) DE3877811T2 (ko)
DK (1) DK174286B1 (ko)
ES (1) ES2053729T3 (ko)
GB (1) GB8710598D0 (ko)
IL (1) IL86258A (ko)
NZ (1) NZ224479A (ko)
ZA (1) ZA883171B (ko)

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* Cited by examiner, † Cited by third party
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US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
JP2962731B2 (ja) * 1986-11-10 1999-10-12 バイオピュアー、コーポレーション 超純枠半合成代用血液
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
ES2086532T3 (es) * 1989-12-29 1996-07-01 Univ Texas Tech Polihemoglobina esterilizada por derivados de la purina y glutation.
DK0519953T3 (da) * 1990-03-14 1996-07-01 Univ Toronto Acylphosphatestere og modificering af proteiner dermed
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
WO1992008478A1 (en) * 1990-11-20 1992-05-29 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
ES2069908T3 (es) * 1990-11-29 1995-05-16 Upjohn Co Composiciones de hemoglobina entrecruzada con imidoesteres.
ATE173273T1 (de) * 1991-02-12 1998-11-15 Univ Texas Tech Verbesserter blutersatz
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
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US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality
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US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
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US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
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US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5691452A (en) * 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
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US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
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DE69831248T2 (de) * 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
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CN105188761B (zh) 2013-03-15 2020-05-15 桑加特公司 聚环氧烷戊酸酯血红蛋白缀合物
JP6807740B2 (ja) 2013-05-03 2021-01-06 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 血液代用組成物及びその使用方法
CN103387613B (zh) * 2013-08-02 2016-12-28 西北大学 一种血红蛋白及血红蛋白氧载体病毒灭活的方法
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Also Published As

Publication number Publication date
IL86258A0 (en) 1988-11-15
CN1032471C (zh) 1996-08-07
JPH0532372B2 (ko) 1993-05-14
DE3877811T2 (de) 1993-05-27
ES2053729T3 (es) 1994-08-01
DK174286B1 (da) 2002-11-11
NZ224479A (en) 1991-04-26
US5364932A (en) 1994-11-15
CA1306583C (en) 1992-08-18
GB8710598D0 (en) 1987-06-10
US4857636A (en) 1989-08-15
EP0290252A2 (en) 1988-11-09
DE3877811D1 (ko) 1993-03-11
EP0290252A3 (en) 1989-01-18
AU1563588A (en) 1988-11-10
ZA883171B (en) 1989-03-29
CN1030425A (zh) 1989-01-18
EP0290252B1 (en) 1993-01-27
KR880013571A (ko) 1988-12-21
JPS63297330A (ja) 1988-12-05
KR910009343B1 (ko) 1991-11-12
DK242888D0 (da) 1988-05-04
AU610883B2 (en) 1991-05-30
ATE84970T1 (de) 1993-02-15
DK242888A (da) 1988-11-06

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