IL85963A - Pharmaceutical compositions for the prophylaxis or treatment of disorders or diseases of the gastrointestinal tract, comprising antigenic substances - Google Patents
Pharmaceutical compositions for the prophylaxis or treatment of disorders or diseases of the gastrointestinal tract, comprising antigenic substancesInfo
- Publication number
- IL85963A IL85963A IL8596388A IL8596388A IL85963A IL 85963 A IL85963 A IL 85963A IL 8596388 A IL8596388 A IL 8596388A IL 8596388 A IL8596388 A IL 8596388A IL 85963 A IL85963 A IL 85963A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical composition
- composition according
- protein
- antigenic
- gastrointestinal tract
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract description 73
- 230000000890 antigenic effect Effects 0.000 title claims abstract description 56
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 36
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 27
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- 208000035475 disorder Diseases 0.000 title claims abstract description 18
- 238000011321 prophylaxis Methods 0.000 title claims abstract description 16
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 25
- 238000011282 treatment Methods 0.000 title claims description 10
- 239000000427 antigen Substances 0.000 claims abstract description 56
- 102000036639 antigens Human genes 0.000 claims abstract description 52
- 108091007433 antigens Proteins 0.000 claims abstract description 52
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- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 11
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- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 27
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 19
- 108010046377 Whey Proteins Proteins 0.000 claims description 19
- JYJIMEQNTHFXMT-UHFFFAOYSA-N 2-nitro-2-phenylacetic acid Chemical compound OC(=O)C([N+]([O-])=O)C1=CC=CC=C1 JYJIMEQNTHFXMT-UHFFFAOYSA-N 0.000 claims description 18
- 102000007544 Whey Proteins Human genes 0.000 claims description 17
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- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 22
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241001514645 Agonis Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 description 1
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- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
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- 241000282849 Ruminantia Species 0.000 description 1
- 235000019755 Starter Diet Nutrition 0.000 description 1
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- 210000002406 gastrin-secreting cell Anatomy 0.000 description 1
- OKGNKPYIPKMGLR-ZPCKCTIPSA-N gastrins Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1NC(=O)CC1)C1=CN=CN1 OKGNKPYIPKMGLR-ZPCKCTIPSA-N 0.000 description 1
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- 229960001340 histamine Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
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- 230000008338 local blood flow Effects 0.000 description 1
- 230000007108 local immune response Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000007433 macroscopic evaluation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 239000000712 neurohormone Substances 0.000 description 1
- 102000008434 neuropeptide hormone activity proteins Human genes 0.000 description 1
- 108040002669 neuropeptide hormone activity proteins Proteins 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
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- 238000009374 poultry farming Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873712890 DE3712890A1 (de) | 1987-04-15 | 1987-04-15 | Verwendung antigener substanzen zur prophylaxe oder therapie von stoerungen und krankheiten im verdauungstrakt von tieren und menschen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL85963A0 IL85963A0 (en) | 1988-09-30 |
| IL85963A true IL85963A (en) | 1994-06-24 |
Family
ID=6325743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL8596388A IL85963A (en) | 1987-04-15 | 1988-04-01 | Pharmaceutical compositions for the prophylaxis or treatment of disorders or diseases of the gastrointestinal tract, comprising antigenic substances |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0286847B1 (da) |
| JP (1) | JP2656063B2 (da) |
| CN (1) | CN88102141A (da) |
| AR (1) | AR243384A1 (da) |
| AT (1) | ATE113478T1 (da) |
| AU (3) | AU1370088A (da) |
| CA (1) | CA1325592C (da) |
| DE (2) | DE3712890A1 (da) |
| DK (1) | DK185988A (da) |
| ES (1) | ES2065894T3 (da) |
| IE (1) | IE66559B1 (da) |
| IL (1) | IL85963A (da) |
| MX (1) | MX170929B (da) |
| NO (1) | NO881629L (da) |
| ZA (1) | ZA882504B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811128A (en) * | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| DE3712890A1 (de) * | 1987-04-15 | 1988-10-27 | Teichmann Reinhard K Priv Doz | Verwendung antigener substanzen zur prophylaxe oder therapie von stoerungen und krankheiten im verdauungstrakt von tieren und menschen |
| US5725861A (en) * | 1987-04-15 | 1998-03-10 | Effem Gmbh | Products and processes for gastric cascade and gastrointestinal disorder treatment with same |
| DE3733899A1 (de) * | 1987-10-07 | 1989-06-15 | Teichmann Reinhard Prof Dr Med | Erzeugnisse und verfahren zur steigerung von wachstumsgeschwindigkeit und/oder nutzung von futter- oder nahrungsmitteln und/oder resistenz bei tieren und menschen |
| JP2849671B2 (ja) * | 1988-11-18 | 1999-01-20 | エッフェム ゲゼルシャフト・ミット・ベシュレンクテル・ハフトウング | 動物又はヒトにおいて成長率及び／又は飼料又は食物の利用及び／又は抵抗性を増加させる製品及びその方法 |
| US6027735A (en) * | 1992-07-28 | 2000-02-22 | Effem Gmbh | Products and processes for gastric cascade and gastrointestinal disorder treatment with same |
| US6815419B1 (en) | 1999-07-28 | 2004-11-09 | Morinaga Milk Industry Co., Ltd. | Antiulcer agent |
| AU2001297937A1 (en) * | 2000-02-21 | 2003-03-03 | Andries Philippus Pretorius | Herbal composition |
| CN102229898B (zh) * | 2011-05-06 | 2012-11-14 | 首都医科大学附属北京友谊医院 | 用于治疗菌群失调症菌群紊乱症的大肠埃希氏菌、制剂及其制备方法 |
| ITFI20130131A1 (it) * | 2013-05-31 | 2014-12-01 | Scapecchi Giorgio | Composizione farmaceutica per la prevenzione ed il trattamento di patologie ad eziologia infettiva |
| CN104777310A (zh) * | 2015-01-23 | 2015-07-15 | 郑振海 | 一种肿瘤相关抗体定量检测试剂盒 |
| CN110551220A (zh) * | 2019-08-29 | 2019-12-10 | 北京勤邦生物技术有限公司 | 一种滴滴涕单克隆抗体的制备及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2825619A1 (de) * | 1977-06-22 | 1979-01-11 | Sandoz Ag | Vakzinen gegen ferkel-colibacillose und verfahren zu ihrer herstellung |
| FR2408351A1 (fr) * | 1977-11-14 | 1979-06-08 | Unilever Nv | Procede et composition destines a la lutte contre la coccidiose chez la volaille |
| EP0059521B1 (en) * | 1981-03-03 | 1985-01-02 | Centraal Diergeneeskundig Instituut | Water-in-oil emulsion for use in the potentation of the immune system of animals |
| NZ199866A (en) * | 1981-03-09 | 1984-11-09 | Cetus Corp | Vaccine for prevention of gastroenteric disease:non-pathogenic strain genetically engineered to comprise genes for adhesin and/or toxoids |
| DE3132412A1 (de) * | 1981-08-17 | 1983-02-24 | Vilas V. Boston Mass. Likhite | Antigene mit immunstimulierenden adjuvanzien und ihre verwendung in der immunotherapie |
| GB2132466B (en) * | 1982-12-22 | 1986-10-15 | Impro Products Inc | Whey product and method for obtaining same |
| US4472302A (en) * | 1983-03-09 | 1984-09-18 | Merck & Co., Inc. | Heat shock process for the isolation of bacterial protein |
| GB8314645D0 (en) * | 1983-05-26 | 1983-06-29 | Wellcome Found | Bivalent vaccines |
| FR2551088B1 (da) * | 1983-08-29 | 1985-12-06 | Pasteur Institut | |
| EP0138242A1 (en) * | 1983-09-07 | 1985-04-24 | Duphar International Research B.V | Method of preparing DNA complementary to the genome of coronaviruses |
| DE3712890A1 (de) * | 1987-04-15 | 1988-10-27 | Teichmann Reinhard K Priv Doz | Verwendung antigener substanzen zur prophylaxe oder therapie von stoerungen und krankheiten im verdauungstrakt von tieren und menschen |
| DE3733899A1 (de) * | 1987-10-07 | 1989-06-15 | Teichmann Reinhard Prof Dr Med | Erzeugnisse und verfahren zur steigerung von wachstumsgeschwindigkeit und/oder nutzung von futter- oder nahrungsmitteln und/oder resistenz bei tieren und menschen |
-
1987
- 1987-04-15 DE DE19873712890 patent/DE3712890A1/de not_active Withdrawn
-
1988
- 1988-03-14 ES ES88104015T patent/ES2065894T3/es not_active Expired - Lifetime
- 1988-03-14 EP EP88104015A patent/EP0286847B1/de not_active Expired - Lifetime
- 1988-03-14 AT AT88104015T patent/ATE113478T1/de active
- 1988-03-14 DE DE3851971T patent/DE3851971D1/de not_active Expired - Fee Related
- 1988-03-24 AU AU13700/88A patent/AU1370088A/en not_active Abandoned
- 1988-04-01 IL IL8596388A patent/IL85963A/en not_active IP Right Cessation
- 1988-04-06 DK DK185988A patent/DK185988A/da not_active Application Discontinuation
- 1988-04-11 ZA ZA882504A patent/ZA882504B/xx unknown
- 1988-04-13 AR AR88310555A patent/AR243384A1/es active
- 1988-04-14 CN CN198888102141A patent/CN88102141A/zh active Pending
- 1988-04-14 NO NO881629A patent/NO881629L/no unknown
- 1988-04-14 IE IE112188A patent/IE66559B1/en not_active IP Right Cessation
- 1988-04-14 JP JP63092647A patent/JP2656063B2/ja not_active Expired - Lifetime
- 1988-04-15 MX MX011130A patent/MX170929B/es unknown
- 1988-04-15 CA CA000564305A patent/CA1325592C/en not_active Expired - Fee Related
-
1992
- 1992-03-12 AU AU12843/92A patent/AU1284392A/en not_active Abandoned
-
1994
- 1994-10-20 AU AU75951/94A patent/AU684824B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2656063B2 (ja) | 1997-09-24 |
| EP0286847A3 (en) | 1990-09-05 |
| EP0286847B1 (de) | 1994-11-02 |
| ES2065894T3 (es) | 1995-03-01 |
| IL85963A0 (en) | 1988-09-30 |
| AR243384A1 (es) | 1993-08-31 |
| DE3851971D1 (de) | 1994-12-08 |
| CN88102141A (zh) | 1988-12-21 |
| ATE113478T1 (de) | 1994-11-15 |
| CA1325592C (en) | 1993-12-28 |
| IE881121L (en) | 1988-10-15 |
| AU1284392A (en) | 1992-05-14 |
| DK185988D0 (da) | 1988-04-06 |
| ZA882504B (en) | 1988-10-11 |
| EP0286847A2 (de) | 1988-10-19 |
| MX170929B (es) | 1993-09-22 |
| AU1370088A (en) | 1988-10-20 |
| JPH01268644A (ja) | 1989-10-26 |
| DE3712890A1 (de) | 1988-10-27 |
| AU7595194A (en) | 1995-01-05 |
| DK185988A (da) | 1988-10-16 |
| AU684824B2 (en) | 1998-01-08 |
| NO881629D0 (no) | 1988-04-14 |
| IE66559B1 (en) | 1996-01-24 |
| NO881629L (no) | 1988-10-17 |
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| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |