IL85328A - Pharmaceutical compositions containing 2,3-dihydroxy- (phenyl, pyridyl or cyclohexenanyl)- quinoxaline derivatives, their preparation and certain novel such quinoxalines - Google Patents
Pharmaceutical compositions containing 2,3-dihydroxy- (phenyl, pyridyl or cyclohexenanyl)- quinoxaline derivatives, their preparation and certain novel such quinoxalinesInfo
- Publication number
- IL85328A IL85328A IL85328A IL8532888A IL85328A IL 85328 A IL85328 A IL 85328A IL 85328 A IL85328 A IL 85328A IL 8532888 A IL8532888 A IL 8532888A IL 85328 A IL85328 A IL 85328A
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- cyclohexenanyl
- quinoxalines
- dihydroxy
- pyridyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 125000004076 pyridyl group Chemical group 0.000 title 1
- 125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 Heterocyclic dihydroxyquinoxaline compounds Chemical class 0.000 abstract 1
- 229910003204 NH2 Inorganic materials 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002964 excitative effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK146787A DK146787A (da) | 1987-03-23 | 1987-03-23 | Heterocykliske forbindelser, deres fremstilling og anvendelse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL85328A true IL85328A (en) | 1993-06-10 |
Family
ID=8105140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL85328A IL85328A (en) | 1987-03-23 | 1988-02-05 | Pharmaceutical compositions containing 2,3-dihydroxy- (phenyl, pyridyl or cyclohexenanyl)- quinoxaline derivatives, their preparation and certain novel such quinoxalines |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4889855A (de) |
| EP (1) | EP0283959B1 (de) |
| KR (1) | KR960003324B1 (de) |
| AT (1) | ATE71090T1 (de) |
| AU (1) | AU596737B2 (de) |
| CA (1) | CA1315789C (de) |
| DE (1) | DE3867268D1 (de) |
| DK (1) | DK146787A (de) |
| ES (1) | ES2037753T3 (de) |
| FI (1) | FI92582C (de) |
| GR (1) | GR3003910T3 (de) |
| IE (1) | IE60002B1 (de) |
| IL (1) | IL85328A (de) |
| NO (1) | NO174549C (de) |
| NZ (1) | NZ223776A (de) |
| PH (1) | PH23979A (de) |
| PT (1) | PT87063B (de) |
| ZA (1) | ZA881139B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743607A (en) * | 1987-05-29 | 1988-05-10 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic tricyclic imidazolones |
| NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
| DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| US5308845A (en) * | 1988-12-22 | 1994-05-03 | Novo Nordisk A/S | Quinoxaline compounds and their preparation and use |
| PT99864B (pt) | 1990-12-21 | 1999-06-30 | Schering Ag | Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato |
| DK73091D0 (da) * | 1991-04-22 | 1991-04-22 | Novo Nordisk As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK0603301T3 (da) * | 1991-09-09 | 1998-09-14 | Warner Lambert Co | Farmaceutisk præparat indeholdende et urikosurikon og en excitatorisk-aminosyre-antagonist |
| DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
| ATE404201T1 (de) * | 1992-06-22 | 2008-08-15 | Univ California | Glycinrezeptorantagonisten und ihre verwendung |
| DE69313866T2 (de) * | 1992-10-13 | 1998-03-05 | Warner Lambert Co | Chinoxalinderivate als eaa antagonisten |
| DK12293D0 (da) * | 1993-02-02 | 1993-02-02 | Novo Nordisk As | Heterocykliske forbindelser og deres fremstilling og anvendelse |
| US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
| ATE161259T1 (de) * | 1993-05-13 | 1998-01-15 | Neurosearch As | Ampa antagonisten und behandlungsmethode |
| US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
| GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
| DE4436852A1 (de) * | 1994-10-14 | 1996-04-18 | Basf Ag | Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung |
| AU4152296A (en) * | 1994-12-07 | 1996-06-26 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones |
| US5721234A (en) * | 1994-12-07 | 1998-02-24 | Warner-Lambert Company | Glutamate receptor antagonists: fused cycloalkylouinoxalinediones |
| ATE204852T1 (de) * | 1995-02-15 | 2001-09-15 | Bearsden Bio Inc | Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor |
| AU4423496A (en) | 1995-03-14 | 1996-10-02 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
| US5719153A (en) * | 1995-08-15 | 1998-02-17 | American Home Products Corporation | 5H,8H-2-oxa-1,3,5,8-tetraaza-cyclopenta b!-naphthalene-6,7-diones |
| WO1998005651A1 (en) * | 1996-08-01 | 1998-02-12 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
| FR2752163B1 (fr) * | 1996-08-12 | 1998-10-30 | Pf Medicament | Utilisation de l'efaroxan pour la fabricaton de medicament destine au traitement de la maladie de huntington |
| US5968928A (en) * | 1996-09-19 | 1999-10-19 | Warner-Lambert Company | Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof |
| EP3427729A1 (de) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen |
| EP4403185A4 (de) | 2021-09-15 | 2025-10-08 | Univ Of The Ryukyus | Pharmazeutische zusammensetzung zur behandlung von kognitivem verfall oder zur behandlung von übergewicht oder adipositas |
| US20240398775A1 (en) | 2021-09-15 | 2024-12-05 | University Of The Ryukyus | Pharmaceutical composition for use in treating cognitive decline or for use in treating overweight or obesity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3431111A (en) * | 1963-06-10 | 1969-03-04 | Eastman Kodak Co | Cyanine dyes |
| US3772273A (en) * | 1969-01-17 | 1973-11-13 | Allied Chem | Derivatives of quinoxaline |
| US3962440A (en) * | 1973-12-26 | 1976-06-08 | Eli Lilly And Company | Quinoxaline compounds as hypnotic agents |
| US4430502A (en) * | 1982-08-13 | 1984-02-07 | The Upjohn Company | Pyridinyl substituted benzimidazoles and quinoxalines |
| FR2583751B1 (fr) * | 1985-06-20 | 1989-10-13 | Panmedica | Nouveaux antibacteriens contenant des derives des acides oxo-4-pyridine carboxyliques et leur procede de preparation |
-
1987
- 1987-03-23 DK DK146787A patent/DK146787A/da not_active IP Right Cessation
-
1988
- 1988-02-05 IL IL85328A patent/IL85328A/xx not_active IP Right Cessation
- 1988-02-16 US US07/156,539 patent/US4889855A/en not_active Expired - Lifetime
- 1988-02-18 ZA ZA881139A patent/ZA881139B/xx unknown
- 1988-02-18 IE IE43988A patent/IE60002B1/en not_active IP Right Cessation
- 1988-02-22 FI FI880816A patent/FI92582C/fi not_active IP Right Cessation
- 1988-02-26 PH PH36561A patent/PH23979A/en unknown
- 1988-03-07 NZ NZ223776A patent/NZ223776A/xx unknown
- 1988-03-17 CA CA000561757A patent/CA1315789C/en not_active Expired - Fee Related
- 1988-03-18 AT AT88104379T patent/ATE71090T1/de not_active IP Right Cessation
- 1988-03-18 ES ES198888104379T patent/ES2037753T3/es not_active Expired - Lifetime
- 1988-03-18 AU AU13260/88A patent/AU596737B2/en not_active Ceased
- 1988-03-18 DE DE8888104379T patent/DE3867268D1/de not_active Expired - Lifetime
- 1988-03-18 EP EP88104379A patent/EP0283959B1/de not_active Expired - Lifetime
- 1988-03-22 KR KR1019880003024A patent/KR960003324B1/ko not_active Expired - Fee Related
- 1988-03-22 NO NO881264A patent/NO174549C/no unknown
- 1988-03-23 PT PT87063A patent/PT87063B/pt active IP Right Grant
-
1989
- 1989-05-03 US US07/347,141 patent/US4912108A/en not_active Expired - Lifetime
-
1992
- 1992-02-27 GR GR920400325T patent/GR3003910T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3867268D1 (de) | 1992-02-13 |
| US4889855A (en) | 1989-12-26 |
| NO174549B (no) | 1994-02-14 |
| EP0283959A1 (de) | 1988-09-28 |
| NO174549C (no) | 1994-05-25 |
| ES2037753T3 (es) | 1993-07-01 |
| PT87063A (pt) | 1988-04-01 |
| IE60002B1 (en) | 1994-05-18 |
| DK146787A (da) | 1988-09-24 |
| FI92582C (fi) | 1994-12-12 |
| FI92582B (fi) | 1994-08-31 |
| NO881264D0 (no) | 1988-03-22 |
| DK146787D0 (da) | 1987-03-23 |
| FI880816A0 (fi) | 1988-02-22 |
| NO881264L (no) | 1988-09-26 |
| KR880011125A (ko) | 1988-10-26 |
| ZA881139B (en) | 1988-08-15 |
| IE880439L (en) | 1988-09-23 |
| AU596737B2 (en) | 1990-05-10 |
| NZ223776A (en) | 1990-10-26 |
| PH23979A (en) | 1990-02-09 |
| KR960003324B1 (ko) | 1996-03-08 |
| PT87063B (pt) | 1992-07-31 |
| ATE71090T1 (de) | 1992-01-15 |
| US4912108A (en) | 1990-03-27 |
| GR3003910T3 (de) | 1993-03-16 |
| AU1326088A (en) | 1988-09-22 |
| FI880816A7 (fi) | 1988-09-24 |
| CA1315789C (en) | 1993-04-06 |
| EP0283959B1 (de) | 1992-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |