IL85004A - 1,4 dihydro-beta-oxo-1-substituted-(1)-benzo(thio)-pyrano-(4,3-c)pyrazole-3-poropanenitrile derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

1,4 dihydro-beta-oxo-1-substituted-(1)-benzo(thio)-pyrano-(4,3-c)pyrazole-3-poropanenitrile derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL85004A
IL85004A IL85004A IL8500488A IL85004A IL 85004 A IL85004 A IL 85004A IL 85004 A IL85004 A IL 85004A IL 8500488 A IL8500488 A IL 8500488A IL 85004 A IL85004 A IL 85004A
Authority
IL
Israel
Prior art keywords
poropanenitrile
pyrano
pyrazole
benzo
thio
Prior art date
Application number
IL85004A
Other languages
English (en)
Other versions
IL85004A0 (en
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878700477A external-priority patent/GB8700477D0/en
Priority claimed from GB878717282A external-priority patent/GB8717282D0/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL85004A0 publication Critical patent/IL85004A0/xx
Publication of IL85004A publication Critical patent/IL85004A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL85004A 1987-01-09 1988-01-01 1,4 dihydro-beta-oxo-1-substituted-(1)-benzo(thio)-pyrano-(4,3-c)pyrazole-3-poropanenitrile derivatives,their preparation and pharmaceutical compositions containing them IL85004A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878700477A GB8700477D0 (en) 1987-01-09 1987-01-09 Heteroaryl 2-cyano-3-oxo-propanamide derivatives
GB878717282A GB8717282D0 (en) 1987-07-22 1987-07-22 Heteroaryl 3-oxo-propanenitrile derivatives

Publications (2)

Publication Number Publication Date
IL85004A0 IL85004A0 (en) 1988-06-30
IL85004A true IL85004A (en) 1991-11-21

Family

ID=26291768

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85004A IL85004A (en) 1987-01-09 1988-01-01 1,4 dihydro-beta-oxo-1-substituted-(1)-benzo(thio)-pyrano-(4,3-c)pyrazole-3-poropanenitrile derivatives,their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US4816467A (da)
EP (1) EP0274443B1 (da)
JP (1) JP2672312B2 (da)
KR (1) KR960002852B1 (da)
CN (1) CN1025500C (da)
AU (1) AU598893B2 (da)
CA (1) CA1310647C (da)
CZ (1) CZ277972B6 (da)
DE (1) DE3862937D1 (da)
DK (1) DK8088A (da)
ES (1) ES2029003T3 (da)
FI (1) FI89489C (da)
GR (1) GR3002032T3 (da)
HU (1) HU198722B (da)
IE (1) IE60620B1 (da)
IL (1) IL85004A (da)
MY (1) MY103348A (da)
NO (1) NO165841C (da)
NZ (1) NZ223113A (da)
PH (1) PH27000A (da)
PT (1) PT86516B (da)
SU (1) SU1695826A3 (da)
YU (2) YU46787B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2061644T3 (es) * 1987-04-09 1994-12-16 Du Pont Indazoles sustituidos insecticidas.
GB8814586D0 (en) * 1988-06-20 1988-07-27 Erba Carlo Spa Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
GB8814587D0 (en) * 1988-06-20 1988-07-27 Erba Carlo Spa Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
GB2227741B (en) * 1989-02-06 1992-08-05 Erba Carlo Spa Condensed 3-oxo-propanenitrile derivatives and process for their preparation
GB8907799D0 (en) * 1989-04-06 1989-05-17 Erba Carlo Spa Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
US5260328A (en) * 1989-04-06 1993-11-09 Farmitalia Carlo Erba Srl Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis
GB8916290D0 (en) * 1989-07-17 1989-08-31 Erba Carlo Spa Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis
DE59010701D1 (de) * 1990-05-18 1997-05-22 Hoechst Ag Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung
US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5886016A (en) * 1995-09-15 1999-03-23 G.D. Searle & Co. Benzopyranopyrazolyl derivatives for the treatment of inflammation
KR100360614B1 (ko) * 1995-11-06 2003-06-02 오르토-맥네일 파마슈티칼, 인코퍼레이티드 1-아릴설포닐,아릴(티오)카르보닐-피리다지노유도체및제조방법
GB9720899D0 (en) * 1997-10-01 1997-12-03 Pharmacia & Upjohn Spa Condensed heterocyclic compounds
CN101289511A (zh) * 2000-04-11 2008-10-22 杰南技术公司 多价抗体及其应用
ATE363473T1 (de) * 2001-09-19 2007-06-15 Pharmacia Corp Substituierte pyrazoloverbindungen zur behandlung von entzündungen
WO2005014051A1 (en) * 2003-08-08 2005-02-17 Barnes-Jewish Hospital Emulsion particles for imaging and therapy and methods of use thereof
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
AU2007244705A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
KR20130049766A (ko) * 2009-11-13 2013-05-14 메르크 세로노 에스. 에이. 트리사이클릭 피라졸 아민 유도체
CN102086212B (zh) * 2009-12-03 2013-06-12 沈阳药科大学 抗真菌剂-2，3，4，5-四氢-4H-苯并[b]噻喃并[4，3-c]吡唑-2-甲酰胺衍生物
US11149082B2 (en) 2016-10-17 2021-10-19 University Of Maryland, College Park Multispecific antibodies targeting human immunodeficiency virus and methods of using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
EP0022446A1 (de) * 1979-04-06 1981-01-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Biotinestern und von Biotin
EP0057932A1 (en) * 1981-02-11 1982-08-18 E.I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 3,4-dihydro(or 1,4-dihydro)-2-((substituted)thiol)-(1)-benzopyrano(3,4-d)imidazoles and their corresponding sulfoxides and sulfones
PH21213A (en) * 1984-10-26 1987-08-21 Fujisawa Pharmaceutical Co Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
NZ223113A (en) 1989-07-27
CZ277972B6 (en) 1993-07-14
YU46787B (sh) 1994-06-10
NO880068D0 (no) 1988-01-08
DE3862937D1 (de) 1991-07-04
HU198722B (en) 1989-11-28
EP0274443A1 (en) 1988-07-13
CA1310647C (en) 1992-11-24
JP2672312B2 (ja) 1997-11-05
NO880068L (no) 1988-07-11
NO165841B (no) 1991-01-07
IE60620B1 (en) 1994-07-27
HUT47113A (en) 1989-01-30
NO165841C (no) 1991-04-17
IL85004A0 (en) 1988-06-30
FI89489C (fi) 1993-10-11
MY103348A (en) 1993-06-30
AU598893B2 (en) 1990-07-05
FI880078A0 (fi) 1988-01-08
FI880078A7 (fi) 1988-07-10
FI89489B (fi) 1993-06-30
PT86516A (en) 1988-02-01
CZ17988A3 (en) 1993-02-17
YU1088A (en) 1989-08-31
CN1025500C (zh) 1994-07-20
CN88100153A (zh) 1988-07-27
SU1695826A3 (ru) 1991-11-30
PH27000A (en) 1993-02-01
JPS63174988A (ja) 1988-07-19
IE880002L (en) 1988-07-09
PT86516B (pt) 1991-12-31
KR960002852B1 (ko) 1996-02-27
ES2029003T3 (es) 1992-07-16
AU1003788A (en) 1988-07-14
YU79489A (en) 1989-10-31
GR3002032T3 (en) 1992-12-30
KR880008987A (ko) 1988-09-13
DK8088A (da) 1988-07-10
US4816467A (en) 1989-03-28
DK8088D0 (da) 1988-01-08
EP0274443B1 (en) 1991-05-29

Similar Documents

Publication Publication Date Title
IL85004A (en) 1,4 dihydro-beta-oxo-1-substituted-(1)-benzo(thio)-pyrano-(4,3-c)pyrazole-3-poropanenitrile derivatives,their preparation and pharmaceutical compositions containing them
IL86923A0 (en) Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
IL86798A (en) 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
IL76405A0 (en) 1,3-diacyl-2-oxyindole derivatives,their preparation and pharmaceutical compositions containing them
IL71243A (en) 1,3-dihydro-3,3-disubstituted-6-methylfuro(3,4-c)pyridin-7-ol derivatives,their preparation and pharmaceutical compositions containing them
NZ224236A (en) Trans 3,4 pyridine derivatives and pharmaceutical compositions
IL81209A (en) Substituted 6h-indolo(2,3-b)-quinoxalines,their preparation and pharmaceutical compositions comprising them
IL87949A0 (en) Dideoxycytidine derivatives,their preparation and pharmaceutical compositions containing them
IL74694A0 (en) N-alkenyl-3-hydroxybenzo(b)thiophene-2-carboxamide derivatives,their preparation and pharmaceutical compositions containing them
IL93136A0 (en) Tetrahydroimidazo(1,4)benzodiazepin-2-thione derivatives,their preparation and pharmaceutical compositions containing them
IL88035A0 (en) Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
IL75135A (en) Hexa-and tetrahydrobenzo(thio)pyrano(3,4-b)pyridines,their preparation and pharmaceutical compositions containing them
IL86890A0 (en) Thiourea derivatives,their preparation and pharmaceutical compositions containing them
IL88002A0 (en) 2,2-dimethylchromene derivatives,their preparation and pharmaceutical compositions containing them
ZA887211B (en) Alkadiene derivatives,their preparation,and pharmaceutical compositions containing them
IL85722A0 (en) Propiolophenone derivatives,their manufacture and pharmaceutical compositions containing them
IL88827A (en) 5,5-dimethyl-3-styryl -2-cyclohexene-1-one oxime derivatives, their preparation and pharmaceutical compositions containing them
IL86888A0 (en) 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives and pharmaceutical compositions containing them
NZ227235A (en) Substituted 1,5-benzothiazepin-4-one derivatives and pharmaceutical compositions
NZ218207A (en) Hexahydro-(1)-benzo(pyrano and thiopyrano)(4,3-c)- pyridines and pharmaceutical compositions
IL90231A0 (en) 1,1-dioxo-cephem-4-carbothiolic acid derivatives,their preparation and pharmaceutical compositions containing them
IL79046A0 (en) Steroido(3,2-c)pyrazoles,their preparation and pharmaceutical compositions containing them
IL76619A0 (en) Thieno-and furo(2,3-c)pyrrole derivatives,their preparation and pharmaceutical compositions containing them
NZ230615A (en) (thio)morpholine-substituted quinoline derivatives and pharmaceutical compositions
IL75527A (en) 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees