IL83433A - Substituted heterocyclic compounds,their preparation and pharmaceutical compositions containing them - Google Patents
Substituted heterocyclic compounds,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL83433A IL83433A IL83433A IL8343387A IL83433A IL 83433 A IL83433 A IL 83433A IL 83433 A IL83433 A IL 83433A IL 8343387 A IL8343387 A IL 8343387A IL 83433 A IL83433 A IL 83433A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- halo
- substituted
- hydrogen
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, carboxy Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868619433A GB8619433D0 (en) | 1986-08-08 | 1986-08-08 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL83433A0 IL83433A0 (en) | 1988-01-31 |
| IL83433A true IL83433A (en) | 1992-03-29 |
Family
ID=10602474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL83433A IL83433A (en) | 1986-08-08 | 1987-08-04 | Substituted heterocyclic compounds,their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4983619A (pt) |
| EP (1) | EP0259972B1 (pt) |
| JP (1) | JPS63246364A (pt) |
| CN (1) | CN1021050C (pt) |
| AT (1) | ATE91489T1 (pt) |
| AU (1) | AU605498B2 (pt) |
| CA (1) | CA1290335C (pt) |
| DE (1) | DE3786507T2 (pt) |
| DK (1) | DK414087A (pt) |
| EG (1) | EG18231A (pt) |
| ES (1) | ES2058118T3 (pt) |
| GB (1) | GB8619433D0 (pt) |
| HU (1) | HU204520B (pt) |
| IL (1) | IL83433A (pt) |
| MX (1) | MX173324B (pt) |
| NZ (1) | NZ221353A (pt) |
| PH (1) | PH23488A (pt) |
| PT (1) | PT85477B (pt) |
| SU (1) | SU1593568A3 (pt) |
| ZA (1) | ZA875812B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5108999A (en) * | 1990-02-02 | 1992-04-28 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| ES2102367T3 (es) * | 1990-05-18 | 1997-08-01 | Hoechst Ag | Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion. |
| US5349068A (en) * | 1992-04-15 | 1994-09-20 | Sterling Winthrop Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| JPH06135948A (ja) * | 1992-10-30 | 1994-05-17 | Taiho Yakuhin Kogyo Kk | スチレン誘導体又はその塩 |
| EP0750496A1 (en) * | 1994-03-14 | 1997-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| KR20160079123A (ko) | 2013-11-22 | 2016-07-05 | 젠자임 코포레이션 | 신경변성 질병을 치료하기 위한 신규한 방법 |
| WO2021050556A1 (en) * | 2019-09-09 | 2021-03-18 | Rutgers, The State University Of New Jersey | Compositions and methods for inhibiting ribosome inactivating proteins |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DK545976A (da) * | 1975-12-11 | 1977-06-12 | Hoechst Ag | Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser |
| DE2655009A1 (de) * | 1976-12-04 | 1978-06-15 | Hoechst Ag | Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| GB1598900A (en) * | 1978-05-23 | 1981-09-23 | Lilly Industries Ltd | Heterocyclic amino derivatives |
| IL60269A (en) * | 1979-06-11 | 1983-12-30 | Ciba Geigy | Alpha-carbamoyl-pyrrolpropionitriles,their preparation and pharmaceutical compositions containing them |
| DE3331874A1 (de) * | 1982-09-13 | 1984-04-05 | Sandoz-Patent-GmbH, 7850 Lörrach | Neue thiophenderivate |
| DE3609542A1 (de) * | 1986-03-21 | 1987-10-01 | Bayer Ag | 5-acylamino-pyrazol-derivate |
-
1986
- 1986-08-08 GB GB868619433A patent/GB8619433D0/en active Pending
-
1987
- 1987-08-02 EG EG449/87A patent/EG18231A/xx active
- 1987-08-03 PH PH35614A patent/PH23488A/en unknown
- 1987-08-04 PT PT85477A patent/PT85477B/pt not_active IP Right Cessation
- 1987-08-04 IL IL83433A patent/IL83433A/xx not_active IP Right Cessation
- 1987-08-05 CA CA000543738A patent/CA1290335C/en not_active Expired - Fee Related
- 1987-08-05 NZ NZ221353A patent/NZ221353A/en unknown
- 1987-08-06 MX MX007667A patent/MX173324B/es unknown
- 1987-08-06 ES ES87306989T patent/ES2058118T3/es not_active Expired - Lifetime
- 1987-08-06 AT AT87306989T patent/ATE91489T1/de active
- 1987-08-06 SU SU874203115A patent/SU1593568A3/ru active
- 1987-08-06 DE DE87306989T patent/DE3786507T2/de not_active Expired - Fee Related
- 1987-08-06 ZA ZA875812A patent/ZA875812B/xx unknown
- 1987-08-06 EP EP87306989A patent/EP0259972B1/en not_active Expired - Lifetime
- 1987-08-07 HU HU873600A patent/HU204520B/hu not_active IP Right Cessation
- 1987-08-07 DK DK414087A patent/DK414087A/da not_active Application Discontinuation
- 1987-08-07 AU AU76680/87A patent/AU605498B2/en not_active Ceased
- 1987-08-07 JP JP62198007A patent/JPS63246364A/ja active Pending
- 1987-08-07 CN CN87105515A patent/CN1021050C/zh not_active Expired - Fee Related
-
1990
- 1990-01-11 US US07/464,644 patent/US4983619A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0259972A2 (en) | 1988-03-16 |
| IL83433A0 (en) | 1988-01-31 |
| GB8619433D0 (en) | 1986-09-17 |
| ES2058118T3 (es) | 1994-11-01 |
| MX173324B (es) | 1994-02-16 |
| DE3786507D1 (de) | 1993-08-19 |
| CN87105515A (zh) | 1988-03-23 |
| HUT46684A (en) | 1988-11-28 |
| SU1593568A3 (ru) | 1990-09-15 |
| CN1021050C (zh) | 1993-06-02 |
| EP0259972A3 (en) | 1990-05-02 |
| NZ221353A (en) | 1990-04-26 |
| EP0259972B1 (en) | 1993-07-14 |
| PH23488A (en) | 1989-08-16 |
| CA1290335C (en) | 1991-10-08 |
| PT85477A (en) | 1987-09-01 |
| ATE91489T1 (de) | 1993-07-15 |
| AU605498B2 (en) | 1991-01-17 |
| MX7667A (es) | 1993-09-01 |
| DE3786507T2 (de) | 1993-11-11 |
| DK414087A (da) | 1988-02-09 |
| HU204520B (en) | 1992-01-28 |
| EG18231A (en) | 1992-10-30 |
| DK414087D0 (da) | 1987-08-07 |
| ZA875812B (en) | 1989-04-26 |
| US4983619A (en) | 1991-01-08 |
| AU7668087A (en) | 1988-02-11 |
| PT85477B (pt) | 1990-06-29 |
| JPS63246364A (ja) | 1988-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH25859A (en) | Composition for treatment of ischemic disorder | |
| GR3015818T3 (en) | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use. | |
| IL103944A0 (en) | Piperazine derivatives,their preparation and pharmaceutical compositions containing them | |
| NZ225408A (en) | Acetohydroxamic acid derivatives and compositions thereof | |
| EP0228845A3 (en) | N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | |
| IL83433A0 (en) | Substituted heterocyclic compounds,their preparation and pharmaceutical compositions containing them | |
| ATE109770T1 (de) | Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten. | |
| DE3362504D1 (en) | 1-carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use | |
| IL86080A0 (en) | Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same | |
| EP0288969A3 (en) | Antiulcer composition | |
| IL73878A0 (en) | Naphthalene derivatives,their preparation and pharmaceutical compositions containing them | |
| IE56000B1 (en) | 1-arylcyclobutylalkylamine compounds | |
| IL74162A0 (en) | Naphthalene derivatives,their preparation and pharmaceutical compositions containing them | |
| HUT50176A (en) | Process for production of derivatives of heterocyclic lactane and medical compositions containing them as active substance | |
| ES8506026A1 (es) | Un procedimiento para la preparacion de un compuesto de b-lactama | |
| IL72491A0 (en) | Aminopyrimidinone derivatives,pharmaceutical compositions containing them,their use as histamine h2-antagonists,processes for their preparation and intermediates therefor | |
| ES8602764A1 (es) | Un procedimiento para preparar derivados de tiadiazina | |
| IL90879A0 (en) | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them | |
| GR3000488T3 (en) | Novel 1,4-dihydropyridines containing fluorine, process for their preparation and their use as medicaments | |
| HUT43930A (en) | Fungicides comprising naphthimidazolone derivatives as active substance and process for preparing the active substance | |
| ES8103092A1 (es) | Un procedimiento para la preparacion de derivados del acido aminodesoxi-clavulanico | |
| GR3004321T3 (pt) | ||
| EP0271192A3 (en) | Purine histamine h1 antagonists, their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |