DE3786507D1 - Heterocyclische propenamid-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents

Heterocyclische propenamid-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Info

Publication number
DE3786507D1
DE3786507D1 DE8787306989T DE3786507T DE3786507D1 DE 3786507 D1 DE3786507 D1 DE 3786507D1 DE 8787306989 T DE8787306989 T DE 8787306989T DE 3786507 T DE3786507 T DE 3786507T DE 3786507 D1 DE3786507 D1 DE 3786507D1
Authority
DE
Germany
Prior art keywords
alkyl
halo
substituted
hydrogen
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787306989T
Other languages
English (en)
Other versions
DE3786507T2 (de
Inventor
Peter Thaddeus Gallagher
Terence Alan Hicks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of DE3786507D1 publication Critical patent/DE3786507D1/de
Publication of DE3786507T2 publication Critical patent/DE3786507T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
DE87306989T 1986-08-08 1987-08-06 Heterocyclische Propenamid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel. Expired - Fee Related DE3786507T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619433A GB8619433D0 (en) 1986-08-08 1986-08-08 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
DE3786507D1 true DE3786507D1 (de) 1993-08-19
DE3786507T2 DE3786507T2 (de) 1993-11-11

Family

ID=10602474

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87306989T Expired - Fee Related DE3786507T2 (de) 1986-08-08 1987-08-06 Heterocyclische Propenamid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.

Country Status (20)

Country Link
US (1) US4983619A (de)
EP (1) EP0259972B1 (de)
JP (1) JPS63246364A (de)
CN (1) CN1021050C (de)
AT (1) ATE91489T1 (de)
AU (1) AU605498B2 (de)
CA (1) CA1290335C (de)
DE (1) DE3786507T2 (de)
DK (1) DK414087A (de)
EG (1) EG18231A (de)
ES (1) ES2058118T3 (de)
GB (1) GB8619433D0 (de)
HU (1) HU204520B (de)
IL (1) IL83433A (de)
MX (1) MX173324B (de)
NZ (1) NZ221353A (de)
PH (1) PH23488A (de)
PT (1) PT85477B (de)
SU (1) SU1593568A3 (de)
ZA (1) ZA875812B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
HU222234B1 (hu) * 1990-05-18 2003-05-28 Aventis Pharma Deutschland Gmbh. Eljárás izoxazol-4-karbonsav-amidok és hidroxi-alkilidén-cián-ecetsav-amidok, a vegyületeket tartalmazó gyógyászati készítmények és az ismert vegyületeket tartalmazó rákellenes hatású gyógyszerkészítmények előállítására
JPH06135948A (ja) * 1992-10-30 1994-05-17 Taiho Yakuhin Kogyo Kk スチレン誘導体又はその塩
WO1995024894A2 (en) * 1994-03-14 1995-09-21 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
WO2015077535A2 (en) 2013-11-22 2015-05-28 Genzyme Corporation Novel methods for treating neurodegenerative diseases
WO2021050556A1 (en) * 2019-09-09 2021-03-18 Rutgers, The State University Of New Jersey Compositions and methods for inhibiting ribosome inactivating proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DK545976A (da) * 1975-12-11 1977-06-12 Hoechst Ag Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
GB1598900A (en) * 1978-05-23 1981-09-23 Lilly Industries Ltd Heterocyclic amino derivatives
PT71367A (en) * 1979-06-11 1980-07-01 Ciba Geigy Ag Process for preparing alphacarbamoyl-pyrrolpropionitriles
DE3331874A1 (de) * 1982-09-13 1984-04-05 Sandoz-Patent-GmbH, 7850 Lörrach Neue thiophenderivate
DE3609542A1 (de) * 1986-03-21 1987-10-01 Bayer Ag 5-acylamino-pyrazol-derivate

Also Published As

Publication number Publication date
DK414087D0 (da) 1987-08-07
ES2058118T3 (es) 1994-11-01
ZA875812B (en) 1989-04-26
EG18231A (en) 1992-10-30
CN87105515A (zh) 1988-03-23
PT85477A (en) 1987-09-01
AU605498B2 (en) 1991-01-17
EP0259972A2 (de) 1988-03-16
DK414087A (da) 1988-02-09
EP0259972B1 (de) 1993-07-14
ATE91489T1 (de) 1993-07-15
US4983619A (en) 1991-01-08
IL83433A0 (en) 1988-01-31
EP0259972A3 (en) 1990-05-02
AU7668087A (en) 1988-02-11
PT85477B (pt) 1990-06-29
HU204520B (en) 1992-01-28
NZ221353A (en) 1990-04-26
IL83433A (en) 1992-03-29
GB8619433D0 (en) 1986-09-17
PH23488A (en) 1989-08-16
JPS63246364A (ja) 1988-10-13
MX7667A (es) 1993-09-01
CN1021050C (zh) 1993-06-02
SU1593568A3 (ru) 1990-09-15
MX173324B (es) 1994-02-16
DE3786507T2 (de) 1993-11-11
HUT46684A (en) 1988-11-28
CA1290335C (en) 1991-10-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee