IL82908A - Pharmaceutical compositions containing neutral metalloendopeptidase inhibitors for treatment of hypertension and their preparation - Google Patents
Pharmaceutical compositions containing neutral metalloendopeptidase inhibitors for treatment of hypertension and their preparationInfo
- Publication number
- IL82908A IL82908A IL82908A IL8290887A IL82908A IL 82908 A IL82908 A IL 82908A IL 82908 A IL82908 A IL 82908A IL 8290887 A IL8290887 A IL 8290887A IL 82908 A IL82908 A IL 82908A
- Authority
- IL
- Israel
- Prior art keywords
- hypertension
- preparation
- treatment
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/876,610 US4749688A (en) | 1986-06-20 | 1986-06-20 | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension |
US07032153 US4801609B1 (en) | 1987-03-27 | 1987-03-27 | Mercapto-acylamino acid antihypertensives |
Publications (2)
Publication Number | Publication Date |
---|---|
IL82908A0 IL82908A0 (en) | 1987-12-20 |
IL82908A true IL82908A (en) | 1991-09-16 |
Family
ID=26708050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL82908A IL82908A (en) | 1986-06-20 | 1987-06-18 | Pharmaceutical compositions containing neutral metalloendopeptidase inhibitors for treatment of hypertension and their preparation |
Country Status (14)
Country | Link |
---|---|
US (1) | US5061710A (de) |
EP (1) | EP0254032A3 (de) |
JP (3) | JP2542620B2 (de) |
KR (1) | KR940001769B1 (de) |
AU (1) | AU636423B2 (de) |
DK (1) | DK313887A (de) |
FI (1) | FI872720A (de) |
HU (1) | HU208952B (de) |
IL (1) | IL82908A (de) |
MY (1) | MY100641A (de) |
NO (1) | NO872589L (de) |
NZ (1) | NZ220753A (de) |
OA (1) | OA08617A (de) |
PT (1) | PT85124B (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262436A (en) * | 1987-03-27 | 1993-11-16 | Schering Corporation | Acylamino acid antihypertensives in the treatment of congestive heart failure |
CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
CA1330613C (en) * | 1988-05-06 | 1994-07-05 | Masanori Kawamura | Amino acid derivatives |
US5202340A (en) * | 1988-05-06 | 1993-04-13 | Ono Pharmaceutical Co., Ltd. | Amino acid derivatives |
WO1990001940A1 (en) * | 1988-08-18 | 1990-03-08 | California Biotechnology Inc. | Atrial natriuretic peptide clearance inhibitors |
FR2651229B1 (fr) * | 1989-08-24 | 1991-12-13 | Inst Nat Sante Rech Med | Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique. |
AU6503390A (en) * | 1989-10-13 | 1991-05-16 | Schering Corporation | Carboxyalkyl dipeptide inhibitors of endopeptidases |
FI922867A (fi) * | 1991-06-21 | 1992-12-22 | Tanabe Seiyaku Co | Dikarbonsyraderivat och foerfarande foer framstaellning av dem |
US5225401A (en) * | 1991-08-12 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Treatment of congestive heart failure |
WO1993005809A1 (en) * | 1991-09-16 | 1993-04-01 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
US5977160A (en) * | 1992-04-10 | 1999-11-02 | Brigham And Women's Hospital, Inc. | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims |
WO1994007481A1 (en) * | 1992-10-02 | 1994-04-14 | Merck & Co., Inc. | N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
JPH06199850A (ja) * | 1992-12-28 | 1994-07-19 | Tanabe Seiyaku Co Ltd | インドール含有ペプチド及びその製法 |
US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
US5616775A (en) * | 1994-05-05 | 1997-04-01 | Bristol-Myers Squibb Co. | Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
WO1996027585A1 (fr) * | 1995-03-07 | 1996-09-12 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives aminoacides ayant un groupe n,n-dialkylaminophenyle |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US6046235A (en) * | 1996-09-05 | 2000-04-04 | Santen Pharmaceutical Co., Ltd. | Sulfur-containing amino acid derivatives |
DE19906310A1 (de) * | 1999-02-16 | 2000-08-17 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von Bluthochdruck |
JP2005516054A (ja) * | 2002-01-29 | 2005-06-02 | ワイス | コネキシンヘミチャンネルを調節する組成物及びその方法 |
US7105539B2 (en) | 2002-12-03 | 2006-09-12 | Enobia Pharma | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex |
US7045653B2 (en) | 2002-12-23 | 2006-05-16 | Pfizer, Inc. | Pharmaceuticals |
CA2523718A1 (en) * | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
MXPA06005547A (es) * | 2003-11-18 | 2006-08-17 | Solvay Pharm Gmbh | Composiciones farmaceuticas para el tratamiento de disfuncion, enfermedad o trastorno renal, en particular, en pacientes diabeticos. |
US7875268B2 (en) | 2004-04-06 | 2011-01-25 | L'oreal S.A. | Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith |
US7816347B2 (en) | 2004-12-15 | 2010-10-19 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors |
WO2007078990A2 (en) | 2005-12-23 | 2007-07-12 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
EP2074087A2 (de) | 2006-12-21 | 2009-07-01 | Wyeth | Synthese von pyrrolidinverbindungen |
US20090298923A1 (en) * | 2008-05-13 | 2009-12-03 | Genmedica Therapeutics Sl | Salicylate Conjugates Useful for Treating Metabolic Disorders |
CN102421424A (zh) * | 2009-03-16 | 2012-04-18 | 根梅迪卡治疗公司 | 用于治疗代谢性疾病的组合疗法 |
WO2010106082A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
EP3087054A4 (de) | 2013-12-27 | 2017-10-25 | Novus International Inc. | Ethoxylierte tenside |
CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
CN108191969B (zh) * | 2018-01-19 | 2021-01-01 | 渤海大学 | 两种来源于大西洋鳟鱼胶原蛋白的ace抑制肽 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US32153A (en) | 1861-04-23 | Improvement in steam-plows | ||
US4105776A (en) | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
US4228077A (en) * | 1976-12-03 | 1980-10-14 | E. R. Squibb & Sons, Inc. | N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes |
CH637374A5 (en) * | 1977-12-02 | 1983-07-29 | Squibb & Sons Inc | Substituted amino acids |
IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4256761A (en) | 1979-07-13 | 1981-03-17 | Usv Pharmaceutical Corporation | Antihypertensive amides |
US4508729A (en) | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
IE52663B1 (en) | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
JPS56158746A (en) * | 1980-04-11 | 1981-12-07 | Wellcome Found | Pharmaceutical amide |
FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
EP0278530A3 (de) | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4470972A (en) | 1981-04-28 | 1984-09-11 | Schering Corporation | 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids |
ATE20469T1 (de) | 1980-10-23 | 1986-07-15 | Schering Corp | Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. |
US4374847A (en) | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
US4462943A (en) | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
US4610816A (en) | 1980-12-18 | 1986-09-09 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
US4820729A (en) | 1981-03-30 | 1989-04-11 | Rorer Pharmaceutical Corporation | N-substituted-amido-amino acids |
US4329495A (en) | 1981-05-18 | 1982-05-11 | Pfizer Inc. | Enkephalinase enzyme inhibiting compounds |
US4401677A (en) * | 1981-10-09 | 1983-08-30 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
US4410520A (en) | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
EP0079522B1 (de) | 1981-11-09 | 1986-05-07 | Merck & Co. Inc. | Antihypertonische N-Carboxymethyl(amidino)-lysyl-prolin-Wirkstoffe |
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
JPS58140065A (ja) * | 1982-02-10 | 1983-08-19 | Meito Sangyo Kk | メルカプトベンジル脂肪酸誘導体類及びその製法 |
GB2128984B (en) | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
US4468519A (en) | 1982-06-14 | 1984-08-28 | E. R. Squibb & Sons, Inc. | Esters of phosphinylalkanoyl substituted prolines |
US4470973A (en) | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
DE3243370A1 (de) * | 1982-11-24 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | Benzoylthioverbindungen, ihre herstellung und verwendung als arzneimittel |
PH22224A (en) | 1983-01-28 | 1988-07-01 | Schering Corp | Phosphorus containing amide compounds and pharmaceutical compositions containing them |
DE3467754D1 (de) * | 1983-10-03 | 1988-01-07 | Squibb & Sons Inc | Enkephalinase inhibitors |
JPS61165362A (ja) * | 1985-01-18 | 1986-07-26 | Meito Sangyo Kk | メルカプト脂肪酸類誘導体およびその利用 |
US4740499A (en) * | 1986-07-28 | 1988-04-26 | Monsanto Company | Method of enhancing the bioactivity of atrial peptides |
CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
-
1987
- 1987-06-17 EP EP19870108730 patent/EP0254032A3/de not_active Withdrawn
- 1987-06-18 NZ NZ220753A patent/NZ220753A/en unknown
- 1987-06-18 IL IL82908A patent/IL82908A/xx not_active IP Right Cessation
- 1987-06-18 OA OA59144A patent/OA08617A/xx unknown
- 1987-06-18 MY MYPI87000833A patent/MY100641A/en unknown
- 1987-06-18 HU HU872786A patent/HU208952B/hu not_active IP Right Cessation
- 1987-06-18 FI FI872720A patent/FI872720A/fi not_active Application Discontinuation
- 1987-06-19 KR KR1019870006214A patent/KR940001769B1/ko not_active IP Right Cessation
- 1987-06-19 PT PT85124A patent/PT85124B/pt not_active IP Right Cessation
- 1987-06-19 NO NO872589A patent/NO872589L/no unknown
- 1987-06-19 JP JP62153219A patent/JP2542620B2/ja not_active Expired - Lifetime
- 1987-06-19 DK DK313887A patent/DK313887A/da not_active Application Discontinuation
- 1987-12-16 US US07/133,669 patent/US5061710A/en not_active Expired - Fee Related
-
1990
- 1990-12-27 AU AU68517/90A patent/AU636423B2/en not_active Ceased
-
1995
- 1995-08-21 JP JP7246554A patent/JPH08176100A/ja active Pending
- 1995-08-21 JP JP7246555A patent/JP2609443B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU7445887A (en) | 1987-12-24 |
JPS6339855A (ja) | 1988-02-20 |
JP2542620B2 (ja) | 1996-10-09 |
MY100641A (en) | 1990-12-29 |
KR940001769B1 (ko) | 1994-03-05 |
NO872589D0 (no) | 1987-06-19 |
US5061710A (en) | 1991-10-29 |
KR880000103A (ko) | 1988-03-23 |
PT85124B (pt) | 1990-08-31 |
PT85124A (en) | 1987-07-01 |
AU636423B2 (en) | 1993-04-29 |
NZ220753A (en) | 1992-02-25 |
JPH08176100A (ja) | 1996-07-09 |
HUT44940A (en) | 1988-05-30 |
EP0254032A2 (de) | 1988-01-27 |
IL82908A0 (en) | 1987-12-20 |
AU6851790A (en) | 1991-07-18 |
DK313887D0 (da) | 1987-06-19 |
AU602701B2 (en) | 1990-10-25 |
HU208952B (en) | 1994-02-28 |
JPH08283153A (ja) | 1996-10-29 |
JP2609443B2 (ja) | 1997-05-14 |
FI872720A0 (fi) | 1987-06-18 |
NO872589L (no) | 1987-12-21 |
DK313887A (da) | 1987-12-21 |
EP0254032A3 (de) | 1990-09-05 |
OA08617A (fr) | 1988-11-30 |
FI872720A (fi) | 1987-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL82908A (en) | Pharmaceutical compositions containing neutral metalloendopeptidase inhibitors for treatment of hypertension and their preparation | |
IL80411A (en) | Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them | |
PT84936A (en) | Process for the preparation of tetrahydronaphthaline and indanederivatives and of pharmaceutical compositions containing the same | |
PT84860A (en) | Process for the preparation of novel tetrahydronaphtalene derivatives and of pharmaceutical compositions containing the same | |
PT86366A (en) | Process for the preparation of phosphinic acid derivatives and of pharmaceutical compositions containing the same | |
PT86311A (en) | Process for the preparation of tetra-hydro-pyridine-oxime o replaced of cholinergic agents and of pharmaceutical compositions containing them | |
NZ222373A (en) | Antihypertensive agents and pharmaceutical compositions containing nor-statine and cyclostatine | |
NZ220345A (en) | Imidazoquinolinylether derivatives and pharmaceutical compositions containing them | |
AU7211787A (en) | Intraocular dosage compositions and method of use | |
PT86365A (en) | Process for the preparation of pyridazodiazepine derivatives and of pharmaceutical compositions containing the same | |
NZ229856A (en) | Derivatives of (aza)naphthalenesultam and pharmaceutical compositions; processes for preparation | |
IL84309A (en) | Esters of hexahydro-8-hydroxy-2,6-methano-2h-quino-lizin-3(4h)-one and related compounds,processes for their preparation and pharmaceutical compositions containing them | |
PT86516A (en) | Process for the preparation of heteroaryl-3-oxo-propani-nitrile derivatives and of pharmaceutical compositions containing the same | |
PT86419A (en) | Process for the preparation of novel chroman derivatives and of pharmaceutical compositions containing the same | |
PT84358A (en) | Process for the preparation of naphthothiazepinones and of pharmaceutical compositions containing the same | |
IL87089A (en) | Derivatives of n-aminobutyl-n- phenylarylamides, their preparation and pharmaceutical compositions containing them | |
PT82984A (en) | Process for the preparation of poly-4-aminopyrrole-2-carboxamido derivatives and of pharmaceutical compositions containing the same | |
PT86407A (en) | Process for the preparation of new alkanesulfonanilide derivatives and pharmaceutical compositions comprising the same | |
PT83495A (en) | Process for the preparation of n-substituted diphenylpiperidines and of pharmaceutical compositions containing the same | |
PT83604A (en) | Process for the preparation of flavone derivatives and of pharmaceutical compositions containing the same | |
PT83188A (en) | Process for the preparation of benzimidazole derivatives and of pharmaceutical compositions containing the same | |
PT85906A (en) | Process for the preparation of 3-propenylcephem derivate and respective pharmaceutical compositions | |
PT85513A (en) | Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same | |
PT83565A (en) | Process for the preparation of acid aryl-heterocyclic-alcoxi-acetic derivatives and of pharmaceutical compositions containing same | |
PT85522A (en) | Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |