NO872589L - AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon. - Google Patents

AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon.

Info

Publication number
NO872589L
NO872589L NO872589A NO872589A NO872589L NO 872589 L NO872589 L NO 872589L NO 872589 A NO872589 A NO 872589A NO 872589 A NO872589 A NO 872589A NO 872589 L NO872589 L NO 872589L
Authority
NO
Norway
Prior art keywords
talloendopeptidase
ntral
hypertension
preparation
treatment
Prior art date
Application number
NO872589A
Other languages
English (en)
Other versions
NO872589D0 (no
Inventor
Martin F Haslanger
Edmund J Sybertz Jr
Bernard R Neustadt
Elizabeth M Smith
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/876,610 external-priority patent/US4749688A/en
Priority claimed from US07032153 external-priority patent/US4801609B1/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO872589D0 publication Critical patent/NO872589D0/no
Publication of NO872589L publication Critical patent/NO872589L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
NO872589A 1986-06-20 1987-06-19 AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon. NO872589L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/876,610 US4749688A (en) 1986-06-20 1986-06-20 Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US07032153 US4801609B1 (en) 1987-03-27 1987-03-27 Mercapto-acylamino acid antihypertensives

Publications (2)

Publication Number Publication Date
NO872589D0 NO872589D0 (no) 1987-06-19
NO872589L true NO872589L (no) 1987-12-21

Family

ID=26708050

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872589A NO872589L (no) 1986-06-20 1987-06-19 AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon.

Country Status (14)

Country Link
US (1) US5061710A (no)
EP (1) EP0254032A3 (no)
JP (3) JP2542620B2 (no)
KR (1) KR940001769B1 (no)
AU (1) AU636423B2 (no)
DK (1) DK313887A (no)
FI (1) FI872720A (no)
HU (1) HU208952B (no)
IL (1) IL82908A (no)
MY (1) MY100641A (no)
NO (1) NO872589L (no)
NZ (1) NZ220753A (no)
OA (1) OA08617A (no)
PT (1) PT85124B (no)

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US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
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Also Published As

Publication number Publication date
AU6851790A (en) 1991-07-18
US5061710A (en) 1991-10-29
JPH08283153A (ja) 1996-10-29
AU636423B2 (en) 1993-04-29
AU602701B2 (en) 1990-10-25
PT85124B (pt) 1990-08-31
JPS6339855A (ja) 1988-02-20
DK313887A (da) 1987-12-21
JP2609443B2 (ja) 1997-05-14
MY100641A (en) 1990-12-29
PT85124A (en) 1987-07-01
FI872720A0 (fi) 1987-06-18
AU7445887A (en) 1987-12-24
IL82908A (en) 1991-09-16
EP0254032A3 (en) 1990-09-05
KR940001769B1 (ko) 1994-03-05
NO872589D0 (no) 1987-06-19
HUT44940A (en) 1988-05-30
EP0254032A2 (en) 1988-01-27
FI872720A (fi) 1987-12-21
HU208952B (en) 1994-02-28
DK313887D0 (da) 1987-06-19
JP2542620B2 (ja) 1996-10-09
OA08617A (fr) 1988-11-30
JPH08176100A (ja) 1996-07-09
IL82908A0 (en) 1987-12-20
KR880000103A (ko) 1988-03-23
NZ220753A (en) 1992-02-25

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