NO872589L - AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon. - Google Patents

AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon.

Info

Publication number
NO872589L
NO872589L NO872589A NO872589A NO872589L NO 872589 L NO872589 L NO 872589L NO 872589 A NO872589 A NO 872589A NO 872589 A NO872589 A NO 872589A NO 872589 L NO872589 L NO 872589L
Authority
NO
Norway
Prior art keywords
talloendopeptidase
ntral
hypertension
preparation
treatment
Prior art date
Application number
NO872589A
Other languages
English (en)
Other versions
NO872589D0 (no
Inventor
Martin F Haslanger
Edmund J Sybertz Jr
Bernard R Neustadt
Elizabeth M Smith
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/876,610 external-priority patent/US4749688A/en
Priority claimed from US07032153 external-priority patent/US4801609B1/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO872589D0 publication Critical patent/NO872589D0/no
Publication of NO872589L publication Critical patent/NO872589L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
NO872589A 1986-06-20 1987-06-19 AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon. NO872589L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/876,610 US4749688A (en) 1986-06-20 1986-06-20 Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US07032153 US4801609B1 (en) 1987-03-27 1987-03-27 Mercapto-acylamino acid antihypertensives

Publications (2)

Publication Number Publication Date
NO872589D0 NO872589D0 (no) 1987-06-19
NO872589L true NO872589L (no) 1987-12-21

Family

ID=26708050

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872589A NO872589L (no) 1986-06-20 1987-06-19 AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon.

Country Status (14)

Country Link
US (1) US5061710A (no)
EP (1) EP0254032A3 (no)
JP (3) JP2542620B2 (no)
KR (1) KR940001769B1 (no)
AU (1) AU636423B2 (no)
DK (1) DK313887A (no)
FI (1) FI872720A (no)
HU (1) HU208952B (no)
IL (1) IL82908A (no)
MY (1) MY100641A (no)
NO (1) NO872589L (no)
NZ (1) NZ220753A (no)
OA (1) OA08617A (no)
PT (1) PT85124B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
JPH02209861A (ja) * 1988-05-06 1990-08-21 Ono Pharmaceut Co Ltd アミノ酸誘導体及び該誘導体を有効成分として含有するエンケファリナーゼ阻害剤
US5202340A (en) * 1988-05-06 1993-04-13 Ono Pharmaceutical Co., Ltd. Amino acid derivatives
EP0429537A4 (en) * 1988-08-18 1991-08-21 California Biotechnology, Inc. Atrial natriuretic peptide clearance inhibitors
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
EP0495822A1 (en) * 1989-10-13 1992-07-29 Schering Corporation Carboxyalkyl dipeptide inhibitors of endopeptidases
FI922867A (fi) * 1991-06-21 1992-12-22 Tanabe Seiyaku Co Dikarbonsyraderivat och foerfarande foer framstaellning av dem
US5225401A (en) * 1991-08-12 1993-07-06 E. R. Squibb & Sons, Inc. Treatment of congestive heart failure
EP0533084A1 (en) * 1991-09-16 1993-03-24 Schering Corporation Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
WO1994007481A1 (en) * 1992-10-02 1994-04-14 Merck & Co., Inc. N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
JPH06199850A (ja) * 1992-12-28 1994-07-19 Tanabe Seiyaku Co Ltd インドール含有ペプチド及びその製法
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
WO1996027585A1 (fr) * 1995-03-07 1996-09-12 Santen Pharmaceutical Co., Ltd. Nouveaux derives aminoacides ayant un groupe n,n-dialkylaminophenyle
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
EP0947502B1 (en) * 1996-09-05 2006-06-21 Santen Pharmaceutical Co., Ltd. Novel sulfur-containing amino acid derivatives
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
WO2003063891A1 (en) * 2002-01-29 2003-08-07 Wyeth Compositions and methods for modulating connexin hemichannels
AU2003291867A1 (en) 2002-12-03 2004-06-23 Biomep Inc. Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
MXPA05011537A (es) * 2003-04-30 2006-01-23 Inst For Pharm Discovery Inc Acidos aminocaboxilicos sustituidos.
ES2297536T3 (es) * 2003-11-18 2008-05-01 Solvay Pharmaceuticals Gmbh Composiciones farmaceuticas para el tratamiento de disfunciones renales.
US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
RU2410118C2 (ru) 2004-12-15 2011-01-27 Зольвай Фармасьютиклз Гмбх ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ НЭП (НЕЙТРАЛЬНОЙ ЭНДОПЕПТИДАЗЫ), ИНГИБИТОРЫ ЭНДОГЕННОЙ ПРОДУЦИРУЮЩЕЙ ЭНДОТЕЛИН СИСТЕМЫ И ИНГИБИТОРЫ ГМГ (ГИДРОКСИМЕТИЛГЛУТАРИЛ)СоА РЕДУКТАЗЫ
ES2443242T3 (es) 2005-12-23 2014-02-18 Zealand Pharma A/S Compuestos modificados miméticos de lisina
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
EP2291182A1 (en) * 2008-05-13 2011-03-09 Genmedica Therapeutics SL Salicylate conjugates useful for treating metabolic disorders
BRPI1011593A2 (pt) * 2009-03-16 2016-03-22 Genmedica Therapeutics Sl "combinação farmacêutica, composição farmaceuticamente aceitavél, e, método para tratar um distúrbio metabólico, para tratar doença pulmonar obstrutiva crônica, e para tratar ou prevenir um ou mais distúrbios metabólicos."
WO2010106082A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
US8993631B2 (en) * 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
EP3087054A4 (en) 2013-12-27 2017-10-25 Novus International Inc. Ethoxylated surfactants
US11324799B2 (en) 2017-05-05 2022-05-10 Zealand Pharma A/S Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
CN108191969B (zh) * 2018-01-19 2021-01-01 渤海大学 两种来源于大西洋鳟鱼胶原蛋白的ace抑制肽

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32153A (en) 1861-04-23 Improvement in steam-plows
US4105776A (en) 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4228077A (en) * 1976-12-03 1980-10-14 E. R. Squibb & Sons, Inc. N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes
CH637374A5 (en) * 1977-12-02 1983-07-29 Squibb & Sons Inc Substituted amino acids
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4256761A (en) 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
JPS56158746A (en) * 1980-04-11 1981-12-07 Wellcome Found Pharmaceutical amide
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0278530A3 (de) 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE3174844D1 (en) 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4470972A (en) 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4374847A (en) 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4462943A (en) 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4610816A (en) 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4820729A (en) 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
US4329495A (en) 1981-05-18 1982-05-11 Pfizer Inc. Enkephalinase enzyme inhibiting compounds
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
DE3226768A1 (de) 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4410520A (en) 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3271043D1 (en) 1981-11-09 1986-06-12 Merck & Co Inc N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
JPS58140065A (ja) * 1982-02-10 1983-08-19 Meito Sangyo Kk メルカプトベンジル脂肪酸誘導体類及びその製法
GB2128984B (en) 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4468519A (en) * 1982-06-14 1984-08-28 E. R. Squibb & Sons, Inc. Esters of phosphinylalkanoyl substituted prolines
US4470973A (en) 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
DE3243370A1 (de) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen Benzoylthioverbindungen, ihre herstellung und verwendung als arzneimittel
PH22224A (en) 1983-01-28 1988-07-01 Schering Corp Phosphorus containing amide compounds and pharmaceutical compositions containing them
DE3467754D1 (de) * 1983-10-03 1988-01-07 Squibb & Sons Inc Enkephalinase inhibitors
JPS61165362A (ja) * 1985-01-18 1986-07-26 Meito Sangyo Kk メルカプト脂肪酸類誘導体およびその利用
US4740499A (en) * 1986-07-28 1988-04-26 Monsanto Company Method of enhancing the bioactivity of atrial peptides
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase

Also Published As

Publication number Publication date
AU6851790A (en) 1991-07-18
US5061710A (en) 1991-10-29
JPH08283153A (ja) 1996-10-29
AU636423B2 (en) 1993-04-29
AU602701B2 (en) 1990-10-25
PT85124B (pt) 1990-08-31
JPS6339855A (ja) 1988-02-20
DK313887A (da) 1987-12-21
JP2609443B2 (ja) 1997-05-14
MY100641A (en) 1990-12-29
PT85124A (en) 1987-07-01
FI872720A0 (fi) 1987-06-18
AU7445887A (en) 1987-12-24
IL82908A (en) 1991-09-16
EP0254032A3 (en) 1990-09-05
KR940001769B1 (ko) 1994-03-05
NO872589D0 (no) 1987-06-19
HUT44940A (en) 1988-05-30
EP0254032A2 (en) 1988-01-27
FI872720A (fi) 1987-12-21
HU208952B (en) 1994-02-28
DK313887D0 (da) 1987-06-19
JP2542620B2 (ja) 1996-10-09
OA08617A (fr) 1988-11-30
JPH08176100A (ja) 1996-07-09
IL82908A0 (en) 1987-12-20
KR880000103A (ko) 1988-03-23
NZ220753A (en) 1992-02-25

Similar Documents

Publication Publication Date Title
NO872589L (no) AnalogifremgangsmŸter for fremstilling av inhibitorer mot ntral me-talloendopeptidase for anvendelse ved behandlin g av hypertensjon.
ZA874413B (en) Neutral metalloendopeptidase inhibitors in the treatment of hypertension
NO894929D0 (no) Verktoey for behandling av undergrunnsbroenner.
NO890103D0 (no) Fremgangsmaate for fremstilling av levende vaksine mot coccidiosis.
NO875045D0 (no) Fremgangsmaate for fremstilling av topiske preparater for behandling av akne.
NO160521C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive 13alfa- alkylgonaner.
NO874869D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO902411D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-hydroksy-n-propylaminer.
NO167859C (no) Fremgangsmaate ved oksydering av alkaner.
DE3788160D1 (de) Plasmabehandlungsvorrichtung.
NO166083C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.
NO894011D0 (no) Fremgangsmaate ved oksydering av alkaner.
AU624067B2 (en) Preparation suitable for use in the treatment of enteric disorders
NO874732D0 (no) Fremgangsmaate for fremstilling av polyolestere av kolofonium.
NO864869D0 (no) Fremgangsmaate for fremstilling av ikke-aromatiske fluorallylamin mao-inhibitorer.
NO894129D0 (no) Fremgangsmaate for fremstilling av polysakkarider ved gjaering.
NO885287L (no) Fremgangsmaate ved behandling av boreslam.
DE68908344D1 (de) Oberflaechenbehandlung von metallen.
NO880292D0 (no) Fremgangsmaate for behandling av humle.
NO893890L (no) Fremgangsmaate for fjerning av sulfider.
IT8819286A0 (it) Procedimento per il trattamento extracorporeo di liquido ascitico.
HU9501218D0 (en) Use of bhap compounds in combination with other non-nucleoside reverse transcriptase inhibitors for the treatment of hiv infection
GB2197199B (en) Medicament for treatment of pregnancy-induced hypertension.
NO890630D0 (no) Fremgangsmaate for behandling av aluminiumholdig avfall.
IT8719010A0 (it) Procedimento di trattamento dimateriali filtranti usati.