IL81611A - N-cycloalkano(1,2-b)indole derivatives of aryl-sulfonamides,their preparation and medicaments containing them - Google Patents

N-cycloalkano(1,2-b)indole derivatives of aryl-sulfonamides,their preparation and medicaments containing them

Info

Publication number
IL81611A
IL81611A IL81611A IL8161187A IL81611A IL 81611 A IL81611 A IL 81611A IL 81611 A IL81611 A IL 81611A IL 8161187 A IL8161187 A IL 8161187A IL 81611 A IL81611 A IL 81611A
Authority
IL
Israel
Prior art keywords
cycloalkano
sulfonamides
aryl
preparation
indole derivatives
Prior art date
Application number
IL81611A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL81611A publication Critical patent/IL81611A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL81611A 1986-02-21 1987-02-18 N-cycloalkano(1,2-b)indole derivatives of aryl-sulfonamides,their preparation and medicaments containing them IL81611A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3605566 1986-02-21
DE19863631824 DE3631824A1 (de) 1986-02-21 1986-09-19 Cycloalkano(1.2-b)indol-sulfonamide

Publications (1)

Publication Number Publication Date
IL81611A true IL81611A (en) 1991-03-10

Family

ID=25841196

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81611A IL81611A (en) 1986-02-21 1987-02-18 N-cycloalkano(1,2-b)indole derivatives of aryl-sulfonamides,their preparation and medicaments containing them

Country Status (19)

Country Link
US (3) US4827032A (ja)
EP (1) EP0242518B1 (ja)
JP (1) JPH075552B2 (ja)
KR (2) KR940007302B1 (ja)
AU (1) AU595855B2 (ja)
CA (1) CA1309414C (ja)
CS (1) CS275837B6 (ja)
DE (2) DE3631824A1 (ja)
DK (1) DK167009B1 (ja)
ES (1) ES2028801T3 (ja)
FI (1) FI86544C (ja)
GR (1) GR3001763T3 (ja)
HU (1) HU198686B (ja)
IE (1) IE59470B1 (ja)
IL (1) IL81611A (ja)
NO (1) NO171633C (ja)
NZ (1) NZ219319A (ja)
PH (1) PH24491A (ja)
PT (1) PT84316B (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) * 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
EP0603432B1 (en) * 1992-12-18 1998-10-21 Smithkline Beecham Plc Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated
DE19507751A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) * 1997-12-24 1999-07-01 Bayer Yakuhin Ltd Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
US7696222B2 (en) * 2005-08-12 2010-04-13 Merck Frosst Canada Ltd Indole derivatives as CRTH2 receptor antagonists
US7662831B2 (en) * 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) * 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
AU2007282949B8 (en) 2006-08-07 2012-10-04 Actelion Pharmaceuticals Ltd. (3-Amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
WO2008075028A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders
CA2675520A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
JP2011526281A (ja) * 2008-06-24 2011-10-06 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のシクロアルカン［ｂ］インドールアンタゴニスト
CN102099342B (zh) * 2008-07-15 2013-07-10 霍夫曼-拉罗奇有限公司 氨基四氢吲唑基乙酸类
MX2011005200A (es) 2008-11-17 2011-06-01 Hoffmann La Roche Acidos naftilaceticos.
CA2740863A1 (en) 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Naphthylacetic acids
CN102216273A (zh) 2008-11-17 2011-10-12 霍夫曼-拉罗奇有限公司 用作crth2拮抗剂或部分激动剂的萘乙酸
TWI562987B (en) 2010-03-22 2016-12-21 Actelion Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
EP2697223B1 (en) 2011-04-14 2016-07-13 Actelion Pharmaceuticals Ltd. 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
PL3119779T3 (pl) 2014-03-17 2019-01-31 Idorsia Pharmaceuticals Ltd Pochodne kwasu azaindolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny d2
JP6484644B2 (ja) 2014-03-18 2019-03-13 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ アザインドール酢酸誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用
MX2018003202A (es) 2015-09-15 2018-06-08 Idorsia Pharmaceuticals Ltd Formas cristalinas.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415322A (fr) * 1963-12-09 1965-10-22 Eastman Kodak Co Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (ja) * 1969-12-18 1972-05-18
CH586678A5 (ja) * 1970-05-25 1977-04-15 Hoffmann La Roche
DE2226702A1 (de) * 1972-05-25 1973-12-13 Schering Ag Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235901A (en) * 1978-05-08 1980-11-25 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

Also Published As

Publication number Publication date
KR870007885A (ko) 1987-09-22
CS8701093A2 (en) 1990-11-14
US4827032A (en) 1989-05-02
AU595855B2 (en) 1990-04-12
US4904797A (en) 1990-02-27
FI870693A0 (fi) 1987-02-19
AU6880887A (en) 1987-08-27
CA1309414C (en) 1992-10-27
DK87187A (da) 1987-08-22
NO870437L (no) 1987-08-24
KR890001982A (ko) 1989-04-07
NO171633B (no) 1993-01-04
EP0242518A1 (de) 1987-10-28
FI86544B (fi) 1992-05-29
IE59470B1 (en) 1994-03-09
JPH0592954A (ja) 1993-04-16
US4965258A (en) 1990-10-23
PH24491A (en) 1990-07-18
DE3631824A1 (de) 1988-03-31
FI86544C (fi) 1992-09-10
NZ219319A (en) 1990-12-21
PT84316A (en) 1987-03-01
NO171633C (no) 1993-04-14
IE870439L (en) 1987-08-21
FI870693A (fi) 1987-08-22
ES2028801T3 (es) 1992-07-16
KR960001914B1 (en) 1996-02-06
HUT44493A (en) 1988-03-28
DE3769191D1 (de) 1991-05-16
PT84316B (pt) 1989-09-14
HU198686B (en) 1989-11-28
KR940007302B1 (ko) 1994-08-12
DK87187D0 (da) 1987-02-20
GR3001763T3 (en) 1992-11-23
DK167009B1 (da) 1993-08-16
EP0242518B1 (de) 1991-04-10
CS275837B6 (en) 1992-03-18
JPH075552B2 (ja) 1995-01-25
NO870437D0 (no) 1987-02-04

Similar Documents

Publication Publication Date Title
IL81611A (en) N-cycloalkano(1,2-b)indole derivatives of aryl-sulfonamides,their preparation and medicaments containing them
IL81201A (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL86877A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL83198A (en) Benzenesulphonamidoindanyl derivatives,their preparation and medicaments containing them
NZ220345A (en) Imidazoquinolinylether derivatives and pharmaceutical compositions containing them
IL80411A0 (en) Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them
IL82246A0 (en) Quinoline derivatives,their preparation and pharmaceutical compositions containing them
IL79309A0 (en) (heterocyclic substituted-phenoxy)alkyl-isoxazoles and-furans,their preparation and pharmaceutical compositions containing them
GR3002636T3 (en) Pyrimidine derivatives, their preparation and medicaments containing these derivatives
IL86798A0 (en) 2,2-dimethylchroman-3-ol derivatives,their preparation and pharmaceutical compositions containing them
IL83432A (en) N-phenylcarboxamide derivatives,their preparation and pharmaceutical compositions containing them
NZ217580A (en) Tetrahydro-2-heterocyclyl alkyl-pyrido(4,3-b)indole derivatives and pharmaceutical compositions
IL82205A0 (en) Substituted alkanesulfonamidophenyl derivatives and pharmaceutical compositions containing them
IL87089A (en) Derivatives of n-aminobutyl-n- phenylarylamides, their preparation and pharmaceutical compositions containing them
IL84098A0 (en) Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
ZA871766B (en) Acetamide derivatives,their preparation and pharmaceutical compositions containing them
IL84128A0 (en) 3-propenylcephem derivatives,their preparation and pharmaceutical compositions containing them
IL88002A0 (en) 2,2-dimethylchromene derivatives,their preparation and pharmaceutical compositions containing them
IL84636A0 (en) Lactam derivatives,their preparation and pharmaceutical compositions containing them
IL80658A0 (en) 6,7,8,9-tetrahydro-10-methyl-pyrido(1,2-a)indol-9-amines and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL83412A0 (en) Pyrimidine derivatives,their preparation and medicaments containing them
IL83753A0 (en) Sulphonamidoethyl derivatives,their preparation and pharmaceutical compositions containing them
EP0256400A3 (en) Pyrimidine derivatives, their preparation and medicaments containing these derivatives
ZA879452B (en) 5-hydroxyethyl derivatives of oxazolidinone-2,their preparation and their therapeutic uses
IL92792A0 (en) Annelated indole derivatives,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
EXP Patent expired