IL80619A - 3-(1,2,4-oxadiazolyl)-and 3-alkoxycarbonyl beta-carboline derivatives and pharmaceutical compositions containing the same - Google Patents
3-(1,2,4-oxadiazolyl)-and 3-alkoxycarbonyl beta-carboline derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL80619A IL80619A IL80619A IL8061986A IL80619A IL 80619 A IL80619 A IL 80619A IL 80619 A IL80619 A IL 80619A IL 8061986 A IL8061986 A IL 8061986A IL 80619 A IL80619 A IL 80619A
- Authority
- IL
- Israel
- Prior art keywords
- oxadiazolyl
- alkoxycarbonyl
- beta
- lower alkyl
- same
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853540653 DE3540653A1 (de) | 1985-11-13 | 1985-11-13 | Neue 3-oxadiazol- und 3-carbonsaeure-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL80619A0 IL80619A0 (en) | 1987-02-27 |
| IL80619A true IL80619A (en) | 1990-11-05 |
Family
ID=6286131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL80619A IL80619A (en) | 1985-11-13 | 1986-11-12 | 3-(1,2,4-oxadiazolyl)-and 3-alkoxycarbonyl beta-carboline derivatives and pharmaceutical compositions containing the same |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4778800A (es) |
| EP (1) | EP0222693B1 (es) |
| JP (1) | JPH0772188B2 (es) |
| AT (1) | ATE62686T1 (es) |
| AU (1) | AU594388B2 (es) |
| CA (1) | CA1332836C (es) |
| DD (1) | DD254007A5 (es) |
| DE (2) | DE3540653A1 (es) |
| DK (1) | DK169270B1 (es) |
| ES (1) | ES2040213T3 (es) |
| FI (1) | FI83961C (es) |
| GR (1) | GR3002051T3 (es) |
| HU (1) | HU195815B (es) |
| IE (1) | IE59343B1 (es) |
| IL (1) | IL80619A (es) |
| NO (1) | NO163735C (es) |
| NZ (1) | NZ218243A (es) |
| PT (1) | PT83725B (es) |
| ZA (1) | ZA868630B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4952584A (en) * | 1986-01-11 | 1990-08-28 | Beecham Group P.L.C. | 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity |
| DE3609699A1 (de) * | 1986-03-20 | 1987-09-24 | Schering Ag | 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester |
| DE3730667A1 (de) * | 1987-09-09 | 1989-03-23 | Schering Ag | Neue ss-carboline |
| DE4212529A1 (de) * | 1992-04-10 | 1993-10-14 | Schering Ag | Verwendung von µ-Carbolinen als nicht-kompetitive Glutamat-Antagonisten |
| HU214331B (hu) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| DE4240672A1 (de) * | 1992-11-24 | 1994-05-26 | Schering Ag | Neues Verfahren zur Herstellung von beta-Carbolinen |
| US20040253891A1 (en) * | 2000-09-12 | 2004-12-16 | Schierenbeck Alan W. | Composite structure for protective garment |
| EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US20050143371A1 (en) * | 2003-07-23 | 2005-06-30 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| WO2010095940A2 (en) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
| FR2953837B1 (fr) * | 2009-12-10 | 2012-03-09 | Sanofi Aventis | Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique |
| FR2953838B1 (fr) * | 2009-12-10 | 2012-02-24 | Sanofi Aventis | Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN112939797A (zh) * | 2021-02-03 | 2021-06-11 | 山东邹平大展新材料有限公司 | 一种法匹拉韦中间体2-胺基丙二酰胺的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
| DE3240511A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinderivaten |
| DE3322895A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s) |
| DE3335323A1 (de) * | 1983-09-27 | 1985-04-04 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DK240184D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
| DK240084D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | New beta-carboline-3-oxadiazolyl derivatives |
| DE3504045A1 (de) * | 1985-02-04 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinen durch dehydrierung |
| DE3540654A1 (de) * | 1985-11-13 | 1987-05-14 | Schering Ag | Phenoxy-substituierte ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
-
1985
- 1985-11-13 DE DE19853540653 patent/DE3540653A1/de not_active Withdrawn
-
1986
- 1986-11-11 DK DK538886A patent/DK169270B1/da not_active IP Right Cessation
- 1986-11-11 EP EP86730187A patent/EP0222693B1/de not_active Expired - Lifetime
- 1986-11-11 AT AT86730187T patent/ATE62686T1/de not_active IP Right Cessation
- 1986-11-11 NZ NZ218243A patent/NZ218243A/xx unknown
- 1986-11-11 ES ES198686730187T patent/ES2040213T3/es not_active Expired - Lifetime
- 1986-11-11 DE DE8686730187T patent/DE3678797D1/de not_active Expired - Lifetime
- 1986-11-12 NO NO864516A patent/NO163735C/no unknown
- 1986-11-12 HU HU864677A patent/HU195815B/hu not_active IP Right Cessation
- 1986-11-12 CA CA000522772A patent/CA1332836C/en not_active Expired - Fee Related
- 1986-11-12 DD DD86296212A patent/DD254007A5/de not_active IP Right Cessation
- 1986-11-12 IL IL80619A patent/IL80619A/xx not_active IP Right Cessation
- 1986-11-12 PT PT83725A patent/PT83725B/pt not_active IP Right Cessation
- 1986-11-13 AU AU65169/86A patent/AU594388B2/en not_active Ceased
- 1986-11-13 US US06/929,866 patent/US4778800A/en not_active Expired - Fee Related
- 1986-11-13 ZA ZA868630A patent/ZA868630B/xx unknown
- 1986-11-13 FI FI864618A patent/FI83961C/fi not_active IP Right Cessation
- 1986-11-13 IE IE299586A patent/IE59343B1/en not_active IP Right Cessation
- 1986-11-13 JP JP61268798A patent/JPH0772188B2/ja not_active Expired - Lifetime
-
1991
- 1991-06-05 GR GR91400602T patent/GR3002051T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6516986A (en) | 1987-05-21 |
| IE862995L (en) | 1987-05-13 |
| FI83961B (fi) | 1991-06-14 |
| ATE62686T1 (de) | 1991-05-15 |
| PT83725B (pt) | 1989-05-12 |
| EP0222693A2 (de) | 1987-05-20 |
| PT83725A (de) | 1986-12-01 |
| CA1332836C (en) | 1994-11-01 |
| FI864618A7 (fi) | 1987-05-14 |
| HUT42094A (en) | 1987-06-29 |
| NO864516D0 (no) | 1986-11-12 |
| HU195815B (en) | 1988-07-28 |
| NO163735B (no) | 1990-04-02 |
| GR3002051T3 (en) | 1992-12-30 |
| NO864516L (no) | 1987-05-14 |
| FI83961C (fi) | 1991-09-25 |
| IL80619A0 (en) | 1987-02-27 |
| DK169270B1 (da) | 1994-09-26 |
| DD254007A5 (de) | 1988-02-10 |
| DE3678797D1 (de) | 1991-05-23 |
| US4778800A (en) | 1988-10-18 |
| DK538886D0 (da) | 1986-11-11 |
| JPS62167779A (ja) | 1987-07-24 |
| DK538886A (da) | 1987-05-14 |
| IE59343B1 (en) | 1994-02-09 |
| ES2040213T3 (es) | 1993-10-16 |
| FI864618A0 (fi) | 1986-11-13 |
| ZA868630B (en) | 1987-06-24 |
| EP0222693B1 (de) | 1991-04-17 |
| NO163735C (no) | 1990-07-11 |
| NZ218243A (en) | 1990-03-27 |
| DE3540653A1 (de) | 1987-05-14 |
| AU594388B2 (en) | 1990-03-08 |
| EP0222693A3 (en) | 1988-01-20 |
| JPH0772188B2 (ja) | 1995-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |