IL77625A - Method of producing high molecular weight sodium hyaluronate by fermentation of streptococcus and a novel streptococcus zooepidemicus strain - Google Patents

Method of producing high molecular weight sodium hyaluronate by fermentation of streptococcus and a novel streptococcus zooepidemicus strain

Info

Publication number
IL77625A
IL77625A IL77625A IL7762586A IL77625A IL 77625 A IL77625 A IL 77625A IL 77625 A IL77625 A IL 77625A IL 7762586 A IL7762586 A IL 7762586A IL 77625 A IL77625 A IL 77625A
Authority
IL
Israel
Prior art keywords
streptococcus
molecular weight
high molecular
sodium hyaluronate
fermentation
Prior art date
Application number
IL77625A
Other languages
English (en)
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/692,692 external-priority patent/US4784990A/en
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Priority to IL9479186A priority Critical patent/IL94791A/xx
Priority to IL9094791A priority patent/IL94791A0/xx
Publication of IL77625A publication Critical patent/IL77625A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/818—Aeration or oxygen transfer technique
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Birds (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL77625A 1985-01-18 1986-01-16 Method of producing high molecular weight sodium hyaluronate by fermentation of streptococcus and a novel streptococcus zooepidemicus strain IL77625A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL9479186A IL94791A (en) 1985-01-18 1986-01-16 High molecular weight sodium hyaluronate
IL9094791A IL94791A0 (en) 1985-01-18 1990-06-19 High molecular weight sodium hyaluronate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/692,692 US4784990A (en) 1985-01-18 1985-01-18 High molecular weight sodium hyaluronate
US06/815,957 US4780414A (en) 1985-01-18 1986-01-09 Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus

Publications (1)

Publication Number Publication Date
IL77625A true IL77625A (en) 1991-04-15

Family

ID=27105017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77625A IL77625A (en) 1985-01-18 1986-01-16 Method of producing high molecular weight sodium hyaluronate by fermentation of streptococcus and a novel streptococcus zooepidemicus strain

Country Status (10)

Country Link
US (1) US4780414A (fr)
EP (2) EP0455263A3 (fr)
JP (2) JP2571908B2 (fr)
AT (1) ATE72835T1 (fr)
AU (1) AU600888B2 (fr)
CA (1) CA1336177C (fr)
DE (1) DE3683969D1 (fr)
HK (1) HK117496A (fr)
IL (1) IL77625A (fr)
WO (1) WO1986004355A1 (fr)

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US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US5102783A (en) * 1990-01-12 1992-04-07 Vetrepharm, Inc. Composition and method for culturing and freezing cells and tissues
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
US5492936A (en) * 1990-11-30 1996-02-20 Allergan, Inc. Bimodal molecular weight hyaluronate formulations and methods for using same
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5496726A (en) * 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
IT1263393B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
DE19712931B4 (de) * 1997-03-27 2004-08-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Gewinnung von Hyaluronsäure
EP1025211B1 (fr) * 1997-10-31 2004-12-15 The Board of Regents of The University of Oklahoma Gene de la synthase de l'hyaluronan et utilisation de ce gene
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
US6521223B1 (en) 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
EP1305064B1 (fr) 2000-07-28 2008-04-23 Anika Therapeutics Inc. Composites bioabsorbables d'acide hyaluronique derive
JP5024497B2 (ja) * 2001-03-27 2012-09-12 キユーピー株式会社 経口用肌改善剤、肌改善方法及び肌改善用食品組成物
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
GB0130603D0 (en) * 2001-12-20 2002-02-06 Renaissance Healthcare Europ L Improvements in or relating to ophthalmic solutions
KR101023049B1 (ko) 2002-06-20 2011-03-24 노보자임스 바이오파마 디케이 에이/에스 2가 염을 사용한 응집 방법
US20040126853A1 (en) * 2002-06-20 2004-07-01 Novozymes A/S Flocculation with divalent salt
EP1543103B1 (fr) * 2002-08-19 2012-02-01 Kolon Life Science, Inc. Micro-organisme produisant de l'acide hyaluronique et procede de purification de l'acide hyaluronique
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
ES2281265B1 (es) 2005-11-24 2008-08-16 Bioiberica, S.A. Composiciones para el tratamiento de la artrosis.
EP3028677A1 (fr) 2005-12-14 2016-06-08 Anika Therapeutics Inc. Traitement de l'arthrite et d'autres troubles musculosquelettiques avec de l'acide hyaluronique réticulé
JPWO2007142285A1 (ja) * 2006-06-07 2009-10-29 協和発酵バイオ株式会社 ヒアルロン酸塩の精製方法
WO2008035372A2 (fr) * 2006-07-06 2008-03-27 Reliance Life Sciences Pvt Ltd Procede efficace de purification d'acide hyaluronique a poids moleculaire eleve
ES2327480B1 (es) 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
US20110130473A1 (en) 2007-11-13 2011-06-02 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
CN102223858B (zh) 2008-10-02 2015-04-01 L.R.R.&D.有限公司 界面层伤口敷料
KR101132114B1 (ko) * 2009-09-15 2012-04-05 일동제약주식회사 히알루론산의 분자량을 조절하는 방법
JP5659483B2 (ja) * 2009-12-01 2015-01-28 三菱化学フーズ株式会社 多糖類の製造方法
FR2963240B1 (fr) * 2010-07-28 2013-03-15 Horus Pharma Composition a usage topique sans conservateur comprenant de l'acide hyaluronique
WO2012169437A1 (fr) 2011-06-09 2012-12-13 三洋化成工業株式会社 Procédé de production de polysaccharide
ES2440390B1 (es) 2012-07-25 2014-11-13 Bioibérica, S.A. Composiciones para el tratamiento del sobrepeso y de la obesidad
CA2896038C (fr) * 2015-07-03 2022-08-09 Glycobiosciences Inc. Compositions de matrice polymere renfermant une concentration elevee d'hyalluonate de sodium bio-fermente et leurs utilisations
ES2638195B1 (es) 2016-04-18 2018-08-02 Bioiberica, S.A. Composiciones para la piel
IT201600079633A1 (it) * 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
WO2018130603A1 (fr) 2017-01-11 2018-07-19 Ferring B.V. Composition pharmaceutique à disintégration rapide
WO2019158541A1 (fr) 2018-02-14 2019-08-22 Frieslandcampina Nederland B.V. Compositions nutritionnelles pour soutien musculo-squelettique pour athlètes
WO2020016820A1 (fr) 2018-07-18 2020-01-23 Bio-Technology General (Israel) Ltd. Procédé de filtration stérile d'un liquide non newtonien et agencement pour celle-ci, et formulation

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US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
JPS5837001A (ja) * 1981-08-27 1983-03-04 Green Cross Corp:The ヒアルロン酸の製造法
JPS5856692A (ja) * 1981-09-26 1983-04-04 Shiseido Co Ltd ヒアルロン酸の製造方法
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
NO160722C (no) * 1983-11-25 1989-05-24 Miles Inc Fremgangsmaate for fremstilling av ultraren hyaluronsyre.
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DE3531612A1 (de) * 1984-09-04 1986-03-27 Chisso Corp., Osaka Verfahren zur herstellung von hyaluronsaeure

Also Published As

Publication number Publication date
US4780414A (en) 1988-10-25
AU600888B2 (en) 1990-08-30
EP0455263A2 (fr) 1991-11-06
AU5359986A (en) 1986-08-13
WO1986004355A1 (fr) 1986-07-31
JP2571908B2 (ja) 1997-01-16
DE3683969D1 (de) 1992-04-02
CA1336177C (fr) 1995-07-04
JPH09143078A (ja) 1997-06-03
ATE72835T1 (de) 1992-03-15
EP0455263A3 (en) 1991-12-11
EP0211037A4 (fr) 1988-09-07
HK117496A (en) 1996-07-12
EP0211037B1 (fr) 1992-02-26
JPH0787962A (ja) 1995-04-04
EP0211037A1 (fr) 1987-02-25
JP3081544B2 (ja) 2000-08-28

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