IL76573A - Synthetic nucleotide sequence coding for a signal sequence for the transport of proteins in expression systems that have a cleavage site for an endonuclease not contained in the natural dna - Google Patents
Synthetic nucleotide sequence coding for a signal sequence for the transport of proteins in expression systems that have a cleavage site for an endonuclease not contained in the natural dnaInfo
- Publication number
- IL76573A IL76573A IL76573A IL7657385A IL76573A IL 76573 A IL76573 A IL 76573A IL 76573 A IL76573 A IL 76573A IL 7657385 A IL7657385 A IL 7657385A IL 76573 A IL76573 A IL 76573A
- Authority
- IL
- Israel
- Prior art keywords
- transport
- endonuclease
- proteins
- contained
- cleavage site
- Prior art date
Links
- 102000004533 Endonucleases Human genes 0.000 title abstract 2
- 108010042407 Endonucleases Proteins 0.000 title abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 title abstract 2
- 238000003776 cleavage reaction Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000007017 scission Effects 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 238000010348 incorporation Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 210000000805 cytoplasm Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843436818 DE3436818A1 (de) | 1984-10-06 | 1984-10-06 | Synthetische signalsequenz zum transport von proteinen in expressionssystemen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL76573A0 IL76573A0 (en) | 1986-02-28 |
| IL76573A true IL76573A (en) | 1992-06-21 |
Family
ID=6247347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL76573A IL76573A (en) | 1984-10-06 | 1985-10-04 | Synthetic nucleotide sequence coding for a signal sequence for the transport of proteins in expression systems that have a cleavage site for an endonuclease not contained in the natural dna |
Country Status (15)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196864A3 (en) * | 1985-03-25 | 1988-03-23 | Cetus Corporation | Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences |
| IT1196484B (it) * | 1986-07-11 | 1988-11-16 | Sclavo Spa | Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe |
| US5426036A (en) * | 1987-05-05 | 1995-06-20 | Hoechst Aktiengesellschaft | Processes for the preparation of foreign proteins in streptomycetes |
| EP0333215B1 (en) * | 1988-03-18 | 1994-08-31 | Wang Laboratories Inc. | Distributed reference and change table for a virtual memory system |
| CA2520415A1 (en) | 2003-03-27 | 2004-10-14 | Ptc Therapeutics, Inc. | Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents |
| WO2004087070A2 (en) | 2003-03-27 | 2004-10-14 | Ptc Therapeutics, Inc. | METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-FUNGAL AGENTS |
| JP4990621B2 (ja) | 2003-07-02 | 2012-08-01 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａプロセシングタンパク質複合体及びその使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5939899A (ja) * | 1982-08-27 | 1984-03-05 | Gakuzo Tamura | 新規ベクタ− |
| US4711844A (en) * | 1983-03-09 | 1987-12-08 | Cetus Corporation | Modified signal peptides |
| NZ207925A (en) * | 1983-04-25 | 1988-05-30 | Genentech Inc | Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture |
| AU3011684A (en) * | 1983-05-19 | 1984-12-04 | Public Health Research Institute Of The City Of New York, Inc., The | Expression and secretion vectors & method of constructing vectors |
| US4663280A (en) * | 1983-05-19 | 1987-05-05 | Public Health Research Institute Of The City Of New York | Expression and secretion vectors and method of constructing vectors |
| JPS6030687A (ja) * | 1983-08-01 | 1985-02-16 | Wakunaga Seiyaku Kk | Ｄνａ遺伝子，その製造法およびそれを含むプラスミド |
| EP0170266B1 (en) * | 1984-07-30 | 1993-03-24 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing protein, and vector, recombinant dna and transformant used therefor |
-
1984
- 1984-10-06 DE DE19843436818 patent/DE3436818A1/de not_active Withdrawn
-
1985
- 1985-09-23 EP EP85112043A patent/EP0177827B1/de not_active Expired - Lifetime
- 1985-09-23 DE DE85112043T patent/DE3587660D1/de not_active Expired - Lifetime
- 1985-09-23 AT AT85112043T patent/ATE97445T1/de not_active IP Right Cessation
- 1985-09-30 HU HU853761A patent/HU197355B/hu unknown
- 1985-10-03 JP JP60221120A patent/JPS6188883A/ja active Pending
- 1985-10-04 PT PT81253A patent/PT81253B/pt unknown
- 1985-10-04 GR GR852405A patent/GR852405B/el unknown
- 1985-10-04 AU AU48333/85A patent/AU595486B2/en not_active Expired
- 1985-10-04 DK DK198504532A patent/DK175511B1/da not_active IP Right Cessation
- 1985-10-04 IL IL76573A patent/IL76573A/xx not_active IP Right Cessation
- 1985-10-04 IE IE244085A patent/IE63262B1/en not_active IP Right Cessation
- 1985-10-04 CA CA000492345A patent/CA1340280C/en not_active Expired - Fee Related
- 1985-10-04 NZ NZ213717A patent/NZ213717A/xx unknown
- 1985-10-04 ES ES547600A patent/ES8605579A1/es not_active Expired
- 1985-10-14 PH PH32879A patent/PH30819A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1340280C (en) | 1998-12-22 |
| DK453285D0 (da) | 1985-10-04 |
| EP0177827B1 (de) | 1993-11-18 |
| DK453285A (da) | 1986-04-07 |
| ATE97445T1 (de) | 1993-12-15 |
| HUT40164A (en) | 1986-11-28 |
| AU4833385A (en) | 1986-04-10 |
| PH30819A (en) | 1997-10-17 |
| JPS6188883A (ja) | 1986-05-07 |
| EP0177827A3 (en) | 1987-12-02 |
| IE63262B1 (en) | 1995-04-05 |
| GR852405B (enrdf_load_stackoverflow) | 1986-02-04 |
| DK175511B1 (da) | 2004-11-15 |
| PT81253A (de) | 1985-11-01 |
| PT81253B (pt) | 1987-11-30 |
| DE3436818A1 (de) | 1986-04-10 |
| IE852440L (en) | 1986-04-06 |
| ES547600A0 (es) | 1986-03-16 |
| DE3587660D1 (de) | 1993-12-23 |
| ES8605579A1 (es) | 1986-03-16 |
| EP0177827A2 (de) | 1986-04-16 |
| IL76573A0 (en) | 1986-02-28 |
| AU595486B2 (en) | 1990-04-05 |
| NZ213717A (en) | 1989-01-06 |
| HU197355B (en) | 1989-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3677685D1 (de) | Signalkodierungsverfahren und zur ausfuehrung dieses verfahrens. | |
| DE3679349D1 (de) | System zur reproduktion von bildern mit gemischtem inhalt. | |
| DE3781548D1 (de) | Verfahren zur verdichtung von materialvorformen. | |
| GR78180B (enrdf_load_stackoverflow) | ||
| FI91160B (fi) | Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi | |
| DE3575550D1 (de) | Verfahren zur umsetzung von alkanen mit niedrigem molekulargewicht. | |
| DE3765799D1 (de) | System zur kodierung und uebertragung von bewegtbildsignalen. | |
| ES547436A0 (es) | Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores | |
| IL76573A (en) | Synthetic nucleotide sequence coding for a signal sequence for the transport of proteins in expression systems that have a cleavage site for an endonuclease not contained in the natural dna | |
| AU5643186A (en) | Recombinant DNA expression vectors and DNA compounds which encode isopenicillin N synthetase | |
| ATE67242T1 (de) | Verfahren zur verbesserung der expression von eukaryontenprotein. | |
| DE3871214D1 (de) | Verfahren zur selektiven alkylierung von biphenyl. | |
| DE3683447D1 (de) | Verfahren zur herstellung von humanlysozym. | |
| FI896261A7 (fi) | Menetelmä proteiinin tai polypeptidin valmistamiseksi, polypeptidiä ko odaava DNA-sekvenssi, DNA-sekvenssin sisältämä mikro-organismi sekä po lypeptidi ja sen käyttö farmaseuttisena valmisteena | |
| FR2528070B1 (fr) | Vecteur d'expression porteur d'un codage genetique pour une proteine liant les phosphates, procede pour sa preparation et procede de production d'un polypeptide en l'utilisant | |
| AU7883887A (en) | Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins | |
| DE3672440D1 (de) | Verfahren zur herstellung teilchenfoermigen materials. | |
| DE3686909D1 (de) | Lymphotoxin-dns, lymphotoxin-expressionsvektor, lymphotoxin-expressionsvektor enthaltender transformant und verfahren zur herstellung von lymphotoxin. | |
| ATE78873T1 (de) | Verfahren zur selektiven spaltung von fusionsproteinen. | |
| DE3584804D1 (de) | Verfahren zur oxydation von alkanen. | |
| ATE83077T1 (de) | Isoelektrisches fokussierverfahren sowie einrichtung zur durchfuehrung dieses verfahrens. | |
| DE3686323D1 (de) | Verfahren zur elektrolyse von kieselerdehaltiger sole. | |
| PL247095A1 (en) | Method of obtaining lignosulfonic coagulate for recovering proteins from waste waters | |
| DE3766105D1 (de) | System zur isolierung von bergbauanlagen und verfahren zur durchfuehrung dieses systems. | |
| PL250409A2 (en) | Method of aerating liquids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |