IL74971A - Preparation of 7-halo-7-deoxylincomycins - Google Patents

Preparation of 7-halo-7-deoxylincomycins

Info

Publication number
IL74971A
IL74971A IL74971A IL7497185A IL74971A IL 74971 A IL74971 A IL 74971A IL 74971 A IL74971 A IL 74971A IL 7497185 A IL7497185 A IL 7497185A IL 74971 A IL74971 A IL 74971A
Authority
IL
Israel
Prior art keywords
halo
adduct
deoxy
deoxylincomycins
preparation
Prior art date
Application number
IL74971A
Other languages
English (en)
Other versions
IL74971A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL74971A0 publication Critical patent/IL74971A0/xx
Publication of IL74971A publication Critical patent/IL74971A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
IL74971A 1984-05-15 1985-04-19 Preparation of 7-halo-7-deoxylincomycins IL74971A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/610,364 US4568741A (en) 1984-05-15 1984-05-15 Synthesis of 7-halo-7-deoxylincomycins

Publications (2)

Publication Number Publication Date
IL74971A0 IL74971A0 (en) 1985-08-30
IL74971A true IL74971A (en) 1991-07-18

Family

ID=24444721

Family Applications (2)

Application Number Title Priority Date Filing Date
IL74971A IL74971A (en) 1984-05-15 1985-04-19 Preparation of 7-halo-7-deoxylincomycins
IL75175A IL75175A0 (en) 1984-05-15 1985-05-13 7-halo-7-deoxylincomycins

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL75175A IL75175A0 (en) 1984-05-15 1985-05-13 7-halo-7-deoxylincomycins

Country Status (18)

Country Link
US (1) US4568741A (es)
EP (1) EP0161794B1 (es)
JP (1) JPS60260591A (es)
KR (1) KR910002224B1 (es)
AT (1) ATE54150T1 (es)
AU (1) AU574453B2 (es)
CA (1) CA1229592A (es)
DE (1) DE3578425D1 (es)
DK (1) DK166390C (es)
ES (1) ES8606877A1 (es)
FI (1) FI78108C (es)
GR (1) GR851150B (es)
HK (1) HK59293A (es)
HU (1) HU196820B (es)
IL (2) IL74971A (es)
MX (1) MX163480B (es)
PT (1) PT80463B (es)
ZA (1) ZA852592B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
TW282399B (es) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
DE4039750A1 (de) * 1990-12-13 1992-06-17 Basf Ag Verfahren zur entfernung von phosgen aus abgasen
JP3202960B2 (ja) 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
JP2005504785A (ja) * 2001-08-28 2005-02-17 ファルマシア・コーポレーション 結晶性クリンダマイシン遊離塩基
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
MXPA05001689A (es) * 2002-08-15 2005-05-27 Vicuron Pharm Inc Derivados de lincomicina que poseen actividad antibacteriana.
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
EP1592420B1 (en) 2003-01-24 2014-01-01 Stiefel Research Australia Pty Ltd Clindamycin phosphate foam
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US8313775B2 (en) * 2003-07-21 2012-11-20 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US8313776B2 (en) * 2003-07-21 2012-11-20 Shionogi Inc. Antibiotic product, use and formulation thereof
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
EP1658034A4 (en) * 2003-08-29 2011-06-22 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
JP2007513869A (ja) * 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005062898A2 (en) * 2003-12-24 2005-07-14 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP2008505124A (ja) * 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8158109B2 (en) 2006-03-31 2012-04-17 Stiefel Research Australia Pty Ltd Foamable suspension gel
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3475407A (en) * 1967-12-22 1969-10-28 Upjohn Co Process for preparing 7(r)- and 7(s)-halolincomycins
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
CA1138443A (en) * 1979-03-09 1982-12-28 Tate & Lyle Patent Holdings Limited Process for the preparation of chloro-deoxysugars
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Also Published As

Publication number Publication date
ATE54150T1 (de) 1990-07-15
DK166390C (da) 1993-09-27
ES542940A0 (es) 1986-05-16
PT80463B (pt) 1987-08-19
FI851941A0 (fi) 1985-05-15
ES8606877A1 (es) 1986-05-16
DK166390B (da) 1993-05-10
EP0161794A2 (en) 1985-11-21
DK196185D0 (da) 1985-05-01
DE3578425D1 (de) 1990-08-02
US4568741A (en) 1986-02-04
AU4095085A (en) 1985-11-21
AU574453B2 (en) 1988-07-07
KR910002224B1 (ko) 1991-04-08
ZA852592B (en) 1985-11-27
JPS60260591A (ja) 1985-12-23
HU196820B (en) 1989-01-30
IL74971A0 (en) 1985-08-30
HK59293A (en) 1993-06-25
IL75175A0 (en) 1985-09-29
EP0161794A3 (en) 1987-07-29
KR850008349A (ko) 1985-12-16
DK196185A (da) 1985-11-16
MX163480B (es) 1992-05-19
CA1229592A (en) 1987-11-24
JPH0533711B2 (es) 1993-05-20
FI851941L (fi) 1985-11-16
FI78108C (fi) 1989-06-12
HUT40805A (en) 1987-02-27
FI78108B (fi) 1989-02-28
GR851150B (es) 1985-11-25
PT80463A (en) 1985-06-01
EP0161794B1 (en) 1990-06-27

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Legal Events

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HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
EXP Patent expired