IL72684A - Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs - Google Patents

Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs

Info

Publication number
IL72684A
IL72684A IL72684A IL7268484A IL72684A IL 72684 A IL72684 A IL 72684A IL 72684 A IL72684 A IL 72684A IL 7268484 A IL7268484 A IL 7268484A IL 72684 A IL72684 A IL 72684A
Authority
IL
Israel
Prior art keywords
anticholinergic
cholinergic
pharmaceutical compositions
transdermal delivery
basic drugs
Prior art date
Application number
IL72684A
Other languages
English (en)
Other versions
IL72684A0 (en
Inventor
Fisher Abraham
Levy Drora
Y Spiegelstein Michael
Grunwald Yaacov
Levy Aharon
Kashnir Moshe
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL72684A priority Critical patent/IL72684A/xx
Application filed by Israel State filed Critical Israel State
Publication of IL72684A0 publication Critical patent/IL72684A0/xx
Priority to JP60075226A priority patent/JPS61186317A/ja
Priority to US06/760,609 priority patent/US4788063A/en
Priority to CA000487829A priority patent/CA1260829A/en
Priority to SE8503664A priority patent/SE462895B/sv
Priority to GB08519530A priority patent/GB2163347B/en
Priority to DK354985A priority patent/DK168585B1/da
Priority to CH3404/85A priority patent/CH667393A5/de
Priority to IT21922/85A priority patent/IT1221024B/it
Priority to DE19853528979 priority patent/DE3528979A1/de
Priority to NO853195A priority patent/NO173486C/no
Priority to FR8512416A priority patent/FR2569112B1/fr
Publication of IL72684A publication Critical patent/IL72684A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL72684A 1984-08-14 1984-08-14 Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs IL72684A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IL72684A IL72684A (en) 1984-08-14 1984-08-14 Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs
JP60075226A JPS61186317A (ja) 1984-08-14 1985-04-09 経皮吸収製剤組成物
US06/760,609 US4788063A (en) 1984-08-14 1985-07-30 Drug delivery system
CA000487829A CA1260829A (en) 1984-08-14 1985-07-31 Drug delivery system
SE8503664A SE462895B (sv) 1984-08-14 1985-08-01 Transdermal farmaceutisk komposition bestaaende av ett kolinergt eller antikolinergt medel och en laagmolekylaer fettsyra samt ett foerband eller en kompress innehaallande kompositionen
GB08519530A GB2163347B (en) 1984-08-14 1985-08-02 Transdermal drug delivery system
DK354985A DK168585B1 (da) 1984-08-14 1985-08-05 Farmaceutisk komposition til transdermal applikation samt forbinding eller pude omfattende samme
CH3404/85A CH667393A5 (de) 1984-08-14 1985-08-08 Pharmazeutische zusammensetzung zur transdermalen verabreichung von basis-arzneimitteln von hoher eigenen spezifischen aktivitaet sowie mittel zu deren verabreichung.
IT21922/85A IT1221024B (it) 1984-08-14 1985-08-12 Sistema di somministrazione di farmaci
DE19853528979 DE3528979A1 (de) 1984-08-14 1985-08-13 Arzneimittelfreigabesystem
NO853195A NO173486C (no) 1984-08-14 1985-08-13 Fremgangsmaate for fremstilling av et farmasoeytisk preparat for transdermal administrasjon av legemidler
FR8512416A FR2569112B1 (fr) 1984-08-14 1985-08-14 Systeme distributeur de medicaments par voie transcutanee

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL72684A IL72684A (en) 1984-08-14 1984-08-14 Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs

Publications (2)

Publication Number Publication Date
IL72684A0 IL72684A0 (en) 1984-11-30
IL72684A true IL72684A (en) 1989-02-28

Family

ID=11055266

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72684A IL72684A (en) 1984-08-14 1984-08-14 Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs

Country Status (12)

Country Link
US (1) US4788063A (da)
JP (1) JPS61186317A (da)
CA (1) CA1260829A (da)
CH (1) CH667393A5 (da)
DE (1) DE3528979A1 (da)
DK (1) DK168585B1 (da)
FR (1) FR2569112B1 (da)
GB (1) GB2163347B (da)
IL (1) IL72684A (da)
IT (1) IT1221024B (da)
NO (1) NO173486C (da)
SE (1) SE462895B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0205247A2 (en) 1985-05-10 1986-12-17 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680172A (en) * 1985-03-05 1987-07-14 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4765985A (en) * 1985-03-05 1988-08-23 Ciba-Geigy Corporation Devices and methods for treating memory impairment
US4666926A (en) * 1986-02-27 1987-05-19 Warner-Lambert Company Transdermal formulations
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4861800A (en) * 1987-08-18 1989-08-29 Buyske Donald A Method for administering the drug deprenyl so as to minimize the danger of side effects
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
US5994392A (en) 1988-02-26 1999-11-30 Neuromedica, Inc. Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
GB8807504D0 (en) * 1988-03-29 1988-05-05 Sandoz Ltd Improvements in/relating to organic compounds
US5075312A (en) * 1988-10-27 1991-12-24 Leitman Esther M Novel anti-micturition composition and method
US5075314A (en) * 1988-10-27 1991-12-24 Leitman Esther M Antimicturition composition and novel method
DE3843238C1 (da) * 1988-12-22 1990-02-22 Lohmann Therapie Syst Lts
DE3843239C1 (da) * 1988-12-22 1990-02-22 Lohmann Therapie Syst Lts
CA2012192A1 (en) * 1989-03-28 1990-09-28 Munir A. Hussain Intranasal administration of physostigmine and arecoline
NZ237241A (en) * 1990-03-02 1993-11-25 Pharmetrix Corp Method for increasing the storage stability of physostigmine
WO1991015176A1 (en) * 1990-04-06 1991-10-17 Pharmetrix Corporation Device and method for enhanced administration of physostigmine
US5429582A (en) * 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
US5931774A (en) * 1991-06-14 1999-08-03 Proxima Therapeutics, Inc. Inflatable devices for tumor treatment
GB9118028D0 (en) * 1991-08-21 1991-10-09 Secr Defence Brit Improved transdrmal formulations
TW224048B (da) * 1992-03-30 1994-05-21 Hoechst Roussel Pharma
US5596007A (en) * 1992-05-18 1997-01-21 Pharmaco Behavioral Associates, Inc. Therapeutic method to alleviate the craving associated with cessation of tobacco with cotinine
US5643928A (en) * 1992-10-21 1997-07-01 Pharmaco Behavioral Associates, Inc. Human body weight management
US5612357A (en) * 1992-05-18 1997-03-18 Pharmaco Behavioral Associates, Inc. Use of cotinine to assist in the cessation of tobacco smoking
US5869505A (en) * 1993-02-02 1999-02-09 Keenan; Robert M. Nicotine metabolites and nicotine dependence
DE4238223C1 (de) * 1992-11-12 1994-05-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung
US5573774A (en) * 1993-02-02 1996-11-12 Keenan; Robert M. Nicotine metabolites, nicotine dependence and human body weight
DE4313928C2 (de) * 1993-04-28 1996-09-19 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur kontrollierten Abgabe von Pilocarpin an die Haut, Verfahren zu seiner Herstellung und seine Verwendung
DE4342174C1 (de) * 1993-12-10 1995-05-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung
JP3908795B2 (ja) * 1994-11-29 2007-04-25 久光製薬株式会社 ケトチフェン含有経皮投与製剤
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
DE19533089C1 (de) * 1995-09-07 1997-05-22 Hexal Ag Tacrin-Pflaster
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US6146656A (en) * 1998-01-22 2000-11-14 Nitto Denko Corporation Percutaneous absorption preparation
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
JP3987655B2 (ja) * 1998-03-03 2007-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬を含有した経皮適用製剤又は坐剤
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
ES2248107T3 (es) 1999-08-31 2006-03-16 Incyte San Diego Incorporated Benciliden-tiazolidindionas y analogos y su utilizacion en el tratamiento de la diabetes.
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
AU2002252227A1 (en) 2001-03-07 2002-09-24 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
CA2473156A1 (en) * 2001-03-08 2002-09-19 Incyte San Diego, Inc. Rxr activating molecules
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
EP1423107B1 (en) 2001-03-23 2012-05-09 Luitpold Pharmaceuticals, Inc. Fatty alcohol drug conjugates
US8552054B2 (en) * 2001-03-23 2013-10-08 Luitpold Pharmaceuticals, Inc. Fatty amine drug conjugates
EP1421061A4 (en) * 2001-08-17 2004-12-22 Incyte San Diego Inc OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA
JPWO2003028723A1 (ja) * 2001-09-27 2005-01-13 埼玉第一製薬株式会社 縮合イミダゾピリジン誘導体を含む経皮吸収用医薬組成物
JP2005513026A (ja) * 2001-11-15 2005-05-12 インサイト サン ディエゴ インコーポレイテッド 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
WO2003059542A1 (en) 2002-01-17 2003-07-24 Lts Lohmann Therapie-Systeme Ag Method for neutralizing or recycling carrier materials for film-like coatings
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US20040087576A1 (en) * 2002-11-05 2004-05-06 Haracz John L. Antimnemonic therapy for hypermemory syndromes
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
MXPA05011242A (es) * 2003-04-18 2006-07-06 Incyte San Diego Inc Compuestos isocromanos sustituidos para el tratamiento de trastornos metabolicos, cancer y otras enfermedades.
DE10338174A1 (de) 2003-08-20 2005-03-24 Lts Lohmann Therapie-Systeme Ag Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20050182044A1 (en) * 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (en) * 2004-06-01 2005-12-01 Axonyx, Inc. Transdermal delivery system for treatment of cognitive disorders
EP1604686A1 (en) * 2004-06-08 2005-12-14 Axonyx, Inc. Use of phenserine and a HMG CoA reductase inhibitor for delaying Alzheimer's disease progression
WO2006053186A2 (en) * 2004-11-10 2006-05-18 The Trustees Of Columbia University In The City Of New York Method for treatment of movement disorders
JP2007308403A (ja) * 2006-05-17 2007-11-29 Kenji Yoshida 皮膚外用剤
US20070287727A1 (en) * 2006-06-08 2007-12-13 Jacob Hiller Anti-Nicotine Treatment
WO2009142968A2 (en) * 2008-05-20 2009-11-26 Olema Pharmaceuticals, Inc. Valproic acid salts
US9732324B2 (en) 2008-10-23 2017-08-15 Cornell University Anti-viral method
HRP20240648T1 (hr) 2013-03-15 2024-08-02 Tonix Pharma Holdings Limited Eutektičke formulacije ciklobenzaprin hidroklorida i manitola
CN118267382A (zh) 2017-12-11 2024-07-02 通尼克斯制药控股有限公司 用于痴呆和神经变性病况中的激越、精神病和认知衰退的环苯扎林治疗

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE521851A (da) *
GB469526A (en) * 1936-10-02 1937-07-27 Earl Barger Putt Acetyl-salicylic acid composition
AR207805A1 (es) * 1975-02-06 1976-10-29 Alza Corp Substrato apropiado para formar apositos para la dispensacion continua de escopolamina base por via transdermica
NL7806048A (nl) * 1978-06-02 1979-12-04 Kali Chemie Pharma Gmbh Geneesmiddel met betere resorptie-eigenschappen en werkwijze voor de bereiding daarvan.
GB2051574B (en) * 1979-05-10 1984-01-18 Kyoto Pharma Ind Adjuvant for promoting absorption of pharmacologically active substances through the rectum
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
NL8104929A (nl) * 1980-11-12 1982-06-01 Alza Corp Anticholinergische preparaten, alsmede de bereiding en de toepassing ervan.
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
DE3204551A1 (de) * 1982-02-10 1983-08-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films
JPS58172312A (ja) * 1982-04-02 1983-10-11 Toa Eiyou Kagaku Kogyo Kk ニフエジピン外用剤
EP0127426A1 (en) * 1983-05-23 1984-12-05 Takeda Chemical Industries, Ltd. Percutaneous pharmaceutical compositions for external use
JPS59216825A (ja) * 1983-05-23 1984-12-06 Takeda Chem Ind Ltd 経皮吸収外用製剤
DK243084A (da) * 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd Perkutane farmaceutiske praeparater til udvortes brug
JPS60199834A (ja) * 1984-03-23 1985-10-09 Takeda Chem Ind Ltd 経皮吸収外用製剤
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0205247A2 (en) 1985-05-10 1986-12-17 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine

Also Published As

Publication number Publication date
US4788063A (en) 1988-11-29
GB8519530D0 (en) 1985-09-11
SE462895B (sv) 1990-09-17
NO173486B (no) 1993-09-13
SE8503664L (sv) 1986-02-15
IT1221024B (it) 1990-06-21
CH667393A5 (de) 1988-10-14
FR2569112B1 (fr) 1988-10-07
DE3528979A1 (de) 1986-02-27
NO853195L (no) 1986-02-17
DK168585B1 (da) 1994-05-02
IT8521922A0 (it) 1985-08-12
JPS61186317A (ja) 1986-08-20
GB2163347A (en) 1986-02-26
DK354985D0 (da) 1985-08-05
NO173486C (no) 1993-12-22
SE8503664D0 (sv) 1985-08-01
GB2163347B (en) 1989-01-25
IL72684A0 (en) 1984-11-30
DK354985A (da) 1986-02-15
CA1260829A (en) 1989-09-26
DE3528979C2 (da) 1989-12-07
FR2569112A1 (fr) 1986-02-21

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