IL68964A - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Info

Publication number
IL68964A
IL68964A IL68964A IL6896483A IL68964A IL 68964 A IL68964 A IL 68964A IL 68964 A IL68964 A IL 68964A IL 6896483 A IL6896483 A IL 6896483A IL 68964 A IL68964 A IL 68964A
Authority
IL
Israel
Prior art keywords
sub
hydrogen
lower alkyl
same
benzazepines
Prior art date
Application number
IL68964A
Other languages
English (en)
Other versions
IL68964A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL68964A0 publication Critical patent/IL68964A0/xx
Publication of IL68964A publication Critical patent/IL68964A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL68964A 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments IL68964A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof

Publications (2)

Publication Number Publication Date
IL68964A0 IL68964A0 (en) 1983-10-31
IL68964A true IL68964A (en) 1988-03-31

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68964A IL68964A (en) 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Country Status (17)

Country Link
US (1) US4988690A (enExample)
EP (1) EP0096838B1 (enExample)
JP (1) JPS595165A (enExample)
KR (1) KR900001214B1 (enExample)
AT (1) ATE26263T1 (enExample)
AU (1) AU570920B2 (enExample)
CA (1) CA1214460A (enExample)
DE (1) DE3370621D1 (enExample)
DK (1) DK270983A (enExample)
ES (1) ES8503666A1 (enExample)
FI (1) FI78473C (enExample)
GR (1) GR78291B (enExample)
HU (1) HU190902B (enExample)
IE (1) IE55404B1 (enExample)
IL (1) IL68964A (enExample)
PT (1) PT76864B (enExample)
ZA (1) ZA834309B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
US7115766B2 (en) * 2000-11-30 2006-10-03 Indiana University Research & Technology Corp. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CA2529320C (en) * 2003-06-17 2013-03-05 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
MXPA05013364A (es) 2003-06-17 2006-03-17 Arena Pharm Inc Procedimiento para preparar 3-benzazepinas.
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
ATE442359T1 (de) 2004-12-21 2009-09-15 Arena Pharm Inc Kristalline formen von (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-be zazepinhydrochlorid
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
WO2007120517A2 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
CA2670285A1 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
AU2008251558B2 (en) * 2007-05-10 2012-12-20 Albany Molecular Research, Inc. Aryloxy-and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
CA3050049A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
MX2015004532A (es) 2012-10-09 2016-01-20 Arena Pharm Inc Metodo de control del peso.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
DK270983A (da) 1983-12-15
AU1576483A (en) 1983-12-22
FI832092L (fi) 1983-12-15
FI78473B (fi) 1989-04-28
HU190902B (en) 1986-12-28
KR900001214B1 (ko) 1990-02-28
IE831384L (en) 1983-12-14
EP0096838B1 (en) 1987-04-01
ZA834309B (en) 1984-03-28
ATE26263T1 (de) 1987-04-15
PT76864B (en) 1986-02-27
US4988690A (en) 1991-01-29
EP0096838A1 (en) 1983-12-28
GR78291B (enExample) 1984-09-26
DE3370621D1 (en) 1987-05-07
IE55404B1 (en) 1990-09-12
KR840005103A (ko) 1984-11-03
ES523191A0 (es) 1985-03-01
ES8503666A1 (es) 1985-03-01
JPS595165A (ja) 1984-01-12
CA1214460A (en) 1986-11-25
PT76864A (en) 1983-07-01
IL68964A0 (en) 1983-10-31
FI832092A0 (fi) 1983-06-10
JPH0365342B2 (enExample) 1991-10-11
FI78473C (fi) 1989-08-10
DK270983D0 (da) 1983-06-13
AU570920B2 (en) 1988-03-31

Similar Documents

Publication Publication Date Title
DE3370621D1 (en) 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
MY109937A (en) Substituted azoles, processes for the preparation thereof, agents containing these, and the use thereof.
CA1262357A (en) N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
PT82854A (en) Process for the preparation of pyridonocarboxylic acid derivatives
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
ES8401961A1 (es) Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
HUT40101A (en) Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
GB8714371D0 (en) Process
ES8601201A1 (es) Procedimiento para preparar derivados de imidazolina
YU217181A (en) Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles
ES8704914A1 (es) Un procedimiento para la preparacion de derivados de 1,5-benzotiazepina'
ES8502122A1 (es) Procedimiento para la preparacion de nuevos compuestos carboxamidicos de pirrol ortocondensado.
ES8401068A1 (es) Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.
DE3160909D1 (en) 5,6,8,9-tetrahydro-7h-dibenz(d,f)azonine derivatives, the production thereof and compositions containing them
ES8601099A1 (es) Procedimiento para la preparacion de nuevos derivados de n-(metoxifenacil)-amina
ES8405020A1 (es) Un procedimiento para la preparacion de derivados de fosfolipidos.
HUT34185A (en) Process for preparing isoquinoline derivatives
HUT43568A (en) Process for preparing novel 2-pyridiyl-acetic acid derivatives and pharmaceutics comprising the same
EP0195374A3 (en) N-substituted 3,4-dihydropyrimidine derivatives, process for the production thereof and composition containing same for treating disorders of cardiovascular system
JPS5636414A (en) Anticonvulsant agent containing omega-aminoalkoxystilbene or its acid addition salt as active constituent
ZA862348B (en) Diamine derivatives
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.
ES8702877A1 (es) Un metodo para producir un derivado de acido benzoico.
ES472897A1 (es) Metodo de preparar derivados de antraquinona
KR840002374A (ko) 디옥산 진통제의 합성방법