IL67455A - Preparation of optically active 2-(6-methoxy-2-naphthyl)propionic acids and derivatives thereof and the novel 1-(6-methoxy-2-naphthyl)-(2-substituted-1-propanone)intermediates therefor - Google Patents

Preparation of optically active 2-(6-methoxy-2-naphthyl)propionic acids and derivatives thereof and the novel 1-(6-methoxy-2-naphthyl)-(2-substituted-1-propanone)intermediates therefor

Info

Publication number
IL67455A
IL67455A IL67455A IL6745582A IL67455A IL 67455 A IL67455 A IL 67455A IL 67455 A IL67455 A IL 67455A IL 6745582 A IL6745582 A IL 6745582A IL 67455 A IL67455 A IL 67455A
Authority
IL
Israel
Prior art keywords
naphthyl
methoxy
optically active
chem
formula
Prior art date
Application number
IL67455A
Other languages
English (en)
Original Assignee
Syntex Pharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23286496&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL67455(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Pharma Int filed Critical Syntex Pharma Int
Priority to IL8431482A priority Critical patent/IL84314A/xx
Priority to IL84314A priority patent/IL84314A0/xx
Priority to IL86920A priority patent/IL86920A0/xx
Publication of IL67455A publication Critical patent/IL67455A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/02—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2
    • C07D317/06—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 2 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Luminescent Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
IL67455A 1981-12-11 1982-12-10 Preparation of optically active 2-(6-methoxy-2-naphthyl)propionic acids and derivatives thereof and the novel 1-(6-methoxy-2-naphthyl)-(2-substituted-1-propanone)intermediates therefor IL67455A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL8431482A IL84314A (en) 1981-12-11 1982-12-10 Single stereoisomers of 1-(6-methoxy-2-naphthyl)-propanone ketals and their use in preparing optically active 2-(6-methoxy-2-naphthyl)propionic acid
IL84314A IL84314A0 (en) 1981-12-11 1987-10-29 Ketals of 1-(6-methoxy-2-naphthyl)-propanones
IL86920A IL86920A0 (en) 1981-12-11 1988-06-30 Cyclic ketals of 1-(6-methoxy-2-naphthyl)-propanones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32967281A 1981-12-11 1981-12-11

Publications (1)

Publication Number Publication Date
IL67455A true IL67455A (en) 1992-09-06

Family

ID=23286496

Family Applications (1)

Application Number Title Priority Date Filing Date
IL67455A IL67455A (en) 1981-12-11 1982-12-10 Preparation of optically active 2-(6-methoxy-2-naphthyl)propionic acids and derivatives thereof and the novel 1-(6-methoxy-2-naphthyl)-(2-substituted-1-propanone)intermediates therefor

Country Status (29)

Country Link
EP (1) EP0081993B1 (de)
JP (4) JPS58135833A (de)
KR (1) KR890000375B1 (de)
AT (1) ATE36517T1 (de)
AU (1) AU560800B2 (de)
CA (2) CA1259627A (de)
CS (1) CS259510B2 (de)
DD (1) DD206372A5 (de)
DE (1) DE3278907D1 (de)
DK (6) DK551782A (de)
ES (1) ES8501732A1 (de)
FI (2) FI82680C (de)
GR (1) GR77059B (de)
HK (1) HK51489A (de)
HU (1) HU191621B (de)
IE (1) IE53922B1 (de)
IL (1) IL67455A (de)
IN (1) IN156354B (de)
IT (1) IT1155421B (de)
MX (1) MX159862A (de)
NO (1) NO156650C (de)
NZ (1) NZ202773A (de)
PH (5) PH20529A (de)
PL (1) PL142997B1 (de)
PT (1) PT75973B (de)
RO (1) RO87021B (de)
SG (1) SG3089G (de)
SU (1) SU1577694A3 (de)
ZA (1) ZA829101B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
DE3461525D1 (en) * 1984-02-02 1987-01-15 Zambon Spa Process for preparing alpha-arylalkanoic acids
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
IT1174084B (it) * 1984-05-10 1987-07-01 Blaschim Spa Procentimento per preparare il naproxen
US4670586A (en) * 1984-09-12 1987-06-02 Nippon Chemicals Co., Ltd. Method for the production of α-aryl-alkanoic acid
IT1190362B (it) * 1985-05-30 1988-02-16 Zambon Spa Preparazione del (6-metossi-2-naftil)-(1-bormoetil)-chetone e dei suoi derivati
IT1188181B (it) * 1985-07-31 1988-01-07 Zambon Spa Processo per la preparazione di acidi carbossilici otticamente attivi e relativi intermedi
IT1198237B (it) * 1986-12-23 1988-12-21 Zambon Spa Intermedi per la sintesi di composti organici
WO1989010350A1 (en) * 1988-04-21 1989-11-02 Ici Australia Operations Proprietary Limited Preparation of an epoxide
IT1240228B (it) * 1989-01-25 1993-11-27 Syntex Inc Preparazione di acidi alfa-metilarenacetici.
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
AU2420395A (en) * 1994-06-08 1996-01-04 Shionogi & Co., Ltd. Process for producing 4-oxo-2-alkenoic ester
JP3744060B2 (ja) * 1996-06-20 2006-02-08 ダイソー株式会社 アシルオキシスルホン酸エステル誘導体の製造法
US20050245764A1 (en) * 2001-08-08 2005-11-03 Koki Yamashita Process for producing optically active 2-substituted carboxylic acid
JP4529119B2 (ja) 2001-08-09 2010-08-25 小野薬品工業株式会社 カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤
SK16482002A3 (sk) * 2002-11-20 2004-06-08 Slovakofarma, A. S. Spôsob prípravy substituovaných derivátov 2-aryl alkánových kyselín
CN106496092B (zh) * 2016-08-30 2019-03-29 江苏宇田医药有限公司 一种用于合成西洛多辛的中间体的制备方法
CN112110801B (zh) * 2020-10-09 2022-07-19 浙江工业大学 一种γ-芳基取代酮类化合物的合成方法
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637767A (en) * 1968-07-30 1972-01-25 Syntex Corp 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
ES455064A1 (es) * 1977-01-17 1978-02-01 Valles Quimica Nuevo procedimiento para la obtencion del acido (d)-2(6-me- toxi-2-naftil)-propionico.
JPS54115358A (en) * 1978-02-25 1979-09-07 Daito Koeki Manufacture of 22*6**substituted naphthoo2**yl* propionic acid
JPS5519214A (en) * 1978-07-27 1980-02-09 Ono Pharmaceut Co Ltd 2-acyl-6-aminomethylphenol derivative and its preparation
JPS55130934A (en) * 1979-03-31 1980-10-11 Masao Sato Ketone synthesis from grignard reagent and acid halide
IE50898B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphthyl)-propan-1-one
IT1212408B (it) * 1980-02-26 1989-11-22 Blaschim Spa Processo per la produzione di acidi alcanoici alfa sostituiti.
JPS5798232A (en) * 1980-11-10 1982-06-18 Sagami Chem Res Center 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
IL65629A (en) * 1981-04-30 1987-08-31 Syntex Pharma Int Preparation of alpha-arylalkanoic acids and esters and salts thereof
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法

Also Published As

Publication number Publication date
NO824175L (no) 1983-06-13
DK461288A (da) 1988-08-17
KR890000375B1 (en) 1989-03-15
HK51489A (en) 1989-07-07
IT8224665A0 (it) 1982-12-10
KR840002764A (ko) 1984-07-16
RO87021A (ro) 1985-05-20
ZA829101B (en) 1984-07-25
JPS58135833A (ja) 1983-08-12
IE822945L (en) 1983-06-11
FI82680C (fi) 1991-04-10
IN156354B (de) 1985-06-29
SU1577694A3 (ru) 1990-07-07
DK461188A (da) 1988-08-17
PH21336A (en) 1987-10-13
DK461188D0 (da) 1988-08-17
DK461288D0 (da) 1988-08-17
DK461388D0 (da) 1988-08-17
CS259510B2 (en) 1988-10-14
PL239456A1 (en) 1984-03-12
RO87021B (ro) 1985-05-31
JPH0420901B2 (de) 1992-04-07
AU9146482A (en) 1983-06-16
JPH02262532A (ja) 1990-10-25
CA1338433C (en) 1996-07-02
CA1259627A (en) 1989-09-19
NZ202773A (en) 1985-12-13
PH20169A (en) 1986-10-09
CS903882A2 (en) 1988-03-15
FI824203A0 (fi) 1982-12-07
GR77059B (de) 1984-09-05
JPH0354652B2 (de) 1991-08-20
ES518086A0 (es) 1984-12-16
JPH02262533A (ja) 1990-10-25
AU560800B2 (en) 1987-04-16
DK461488D0 (da) 1988-08-17
MX159862A (es) 1989-09-21
PH20529A (en) 1987-02-09
PT75973B (en) 1985-10-04
FI82680B (fi) 1990-12-31
PH22187A (en) 1988-06-28
IE53922B1 (en) 1989-04-12
DE3278907D1 (en) 1988-09-22
NO156650B (no) 1987-07-20
PH20059A (en) 1986-09-18
IT8224665A1 (it) 1984-06-10
IT1155421B (it) 1987-01-28
PL142997B1 (en) 1987-12-31
ES8501732A1 (es) 1984-12-16
JPH02270840A (ja) 1990-11-05
EP0081993B1 (de) 1988-08-17
DK551782A (da) 1983-09-26
DK461388A (da) 1988-08-17
ATE36517T1 (de) 1988-09-15
EP0081993A2 (de) 1983-06-22
DK461588A (da) 1988-08-17
SG3089G (en) 1989-06-02
DD206372A5 (de) 1984-01-25
HU191621B (en) 1987-03-30
DK461488A (da) 1988-08-17
EP0081993A3 (en) 1984-01-11
FI824203L (fi) 1983-06-12
FI901487A0 (fi) 1990-03-26
NO156650C (no) 1987-10-28
DK461588D0 (da) 1988-08-17

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