JPS55130934A - Ketone synthesis from grignard reagent and acid halide - Google Patents

Ketone synthesis from grignard reagent and acid halide

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Publication number
JPS55130934A
JPS55130934A JP3770079A JP3770079A JPS55130934A JP S55130934 A JPS55130934 A JP S55130934A JP 3770079 A JP3770079 A JP 3770079A JP 3770079 A JP3770079 A JP 3770079A JP S55130934 A JPS55130934 A JP S55130934A
Authority
JP
Japan
Prior art keywords
acid halide
grignard reagent
carboxylic acid
formula
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3770079A
Other languages
Japanese (ja)
Inventor
Masao Sato
Fumie Satou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP3770079A priority Critical patent/JPS55130934A/en
Publication of JPS55130934A publication Critical patent/JPS55130934A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a ketone useful for preparing various reagents, medicines, agricultural chemicals and dyes, in high yield by reacting a Grignard reagent with a carboxylic acid halide, which are easily available, in a specific solvent at a specified temperature.
CONSTITUTION: A Grignard reagent (G) of the formula R1MgX is reacted with a carboxylic acid halide of the formula R2COX (R1 and R2 are the same or different organic groups selected from straight or branched chain alkyl, cycloalkyl, aryl, and aralkyl groups, and may have a substituent which is inert to the reactants and product; X is halogen) in a solvent which has a great coordination force with G, e.g. tetrahydrofuran or diethylene glycol dimethyl ether, at 0°C or below, preferably -30W-78°C, to give the objective compund. The method is applicable to a wide combination of raw materials, and useful for the synthesis of a number of ketones.
COPYRIGHT: (C)1980,JPO&Japio
JP3770079A 1979-03-31 1979-03-31 Ketone synthesis from grignard reagent and acid halide Pending JPS55130934A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3770079A JPS55130934A (en) 1979-03-31 1979-03-31 Ketone synthesis from grignard reagent and acid halide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3770079A JPS55130934A (en) 1979-03-31 1979-03-31 Ketone synthesis from grignard reagent and acid halide

Publications (1)

Publication Number Publication Date
JPS55130934A true JPS55130934A (en) 1980-10-11

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ID=12504804

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3770079A Pending JPS55130934A (en) 1979-03-31 1979-03-31 Ketone synthesis from grignard reagent and acid halide

Country Status (1)

Country Link
JP (1) JPS55130934A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081993A2 (en) * 1981-12-11 1983-06-22 Syntex Pharmaceuticals International Limited Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids
JPS5920955A (en) * 1982-07-27 1984-02-02 Sony Corp Deflecting yoke
US4450296A (en) * 1980-09-18 1984-05-22 International Flavors & Fragrances Inc. Process for the production of arylalkanone and intermediate
US4605758A (en) * 1981-12-11 1986-08-12 Syntex Pharmaceuticals International Ltd. Preparation of α-arylalkanoic acids
US4827044A (en) * 1987-03-11 1989-05-02 Societe Nationale Elf Aquitaine Process of preparation of ketones
US5210258A (en) * 1981-12-11 1993-05-11 Syntex Pharmaceuticals International Ltd. Optically active alpha-naththylalkyl ketones
JP2007153785A (en) * 2005-12-02 2007-06-21 Sanei Gen Ffi Inc Method for producing 2-acetyl-1-pyrroline
JP2009298715A (en) * 2008-06-11 2009-12-24 Central Glass Co Ltd Method for producing high purity 2'-trifluoromethylpropiophenone
JP2012519192A (en) * 2009-03-04 2012-08-23 ディーエスエム アイピー アセッツ ビー．ブイ． Method for preparing acylbenzene
JP2014009170A (en) * 2012-06-28 2014-01-20 Toray Fine Chemicals Co Ltd Production method of silicon compound

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450296A (en) * 1980-09-18 1984-05-22 International Flavors & Fragrances Inc. Process for the production of arylalkanone and intermediate
JPH0354652B2 (en) * 1981-12-11 1991-08-20
JPS58135833A (en) * 1981-12-11 1983-08-12 シンテツクス・フア−マシユ−テイカルズ・インタ−ナシヨナル・リミテツド Manufacture of alpha-arylalkane
US4605758A (en) * 1981-12-11 1986-08-12 Syntex Pharmaceuticals International Ltd. Preparation of α-arylalkanoic acids
EP0081993A2 (en) * 1981-12-11 1983-06-22 Syntex Pharmaceuticals International Limited Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids
US5210258A (en) * 1981-12-11 1993-05-11 Syntex Pharmaceuticals International Ltd. Optically active alpha-naththylalkyl ketones
JPS5920955A (en) * 1982-07-27 1984-02-02 Sony Corp Deflecting yoke
US4827044A (en) * 1987-03-11 1989-05-02 Societe Nationale Elf Aquitaine Process of preparation of ketones
JP2007153785A (en) * 2005-12-02 2007-06-21 Sanei Gen Ffi Inc Method for producing 2-acetyl-1-pyrroline
JP4643424B2 (en) * 2005-12-02 2011-03-02 三栄源エフ・エフ・アイ株式会社 Method for producing 2-acetyl-1-pyrroline
JP2009298715A (en) * 2008-06-11 2009-12-24 Central Glass Co Ltd Method for producing high purity 2'-trifluoromethylpropiophenone
JP2012519192A (en) * 2009-03-04 2012-08-23 ディーエスエム アイピー アセッツ ビー．ブイ． Method for preparing acylbenzene
US8642800B2 (en) 2009-03-04 2014-02-04 Dsm Ip Assets B.V. Preparation method of acylbenzenes
JP2014009170A (en) * 2012-06-28 2014-01-20 Toray Fine Chemicals Co Ltd Production method of silicon compound

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