IL67445A - Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids - Google Patents
Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acidsInfo
- Publication number
- IL67445A IL67445A IL67445A IL6744582A IL67445A IL 67445 A IL67445 A IL 67445A IL 67445 A IL67445 A IL 67445A IL 6744582 A IL6744582 A IL 6744582A IL 67445 A IL67445 A IL 67445A
- Authority
- IL
- Israel
- Prior art keywords
- steroidal anti
- carboxylic acids
- ethyl esters
- esters
- inflammatory carboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Fats And Perfumes (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL67445A IL67445A (en) | 1982-12-09 | 1982-12-09 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
AU21056/83A AU563459B2 (en) | 1982-12-09 | 1983-11-08 | Ethoxycarbonyloxy ethyl esters |
ZA838591A ZA838591B (en) | 1982-12-09 | 1983-11-17 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
DE8383307490T DE3369972D1 (en) | 1982-12-09 | 1983-12-08 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use |
JP58230741A JPS59112944A (ja) | 1982-12-09 | 1983-12-08 | 非ステロイド抗炎症カルボン酸のエトキシカルボニルオキシエチルエステル、その製造方法および該エトキシカルボニルオキシエチルエステルを有効成分とする医薬組成物 |
AT83307490T ATE25665T1 (de) | 1982-12-09 | 1983-12-08 | Aethoxycarbonyloxyaethylester von nichtsteroiden entzuendungshemmenden carbonsaeuren, ihre herstellung und anwendung. |
EP83307490A EP0112130B1 (en) | 1982-12-09 | 1983-12-08 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use |
US06/810,393 US4851426A (en) | 1982-12-09 | 1986-02-12 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids and pharmaceutical compositions thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL67445A IL67445A (en) | 1982-12-09 | 1982-12-09 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
IL67445A0 IL67445A0 (en) | 1983-05-15 |
IL67445A true IL67445A (en) | 1985-11-29 |
Family
ID=11053929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL67445A IL67445A (en) | 1982-12-09 | 1982-12-09 | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
Country Status (8)
Country | Link |
---|---|
US (1) | US4851426A (xx) |
EP (1) | EP0112130B1 (xx) |
JP (1) | JPS59112944A (xx) |
AT (1) | ATE25665T1 (xx) |
AU (1) | AU563459B2 (xx) |
DE (1) | DE3369972D1 (xx) |
IL (1) | IL67445A (xx) |
ZA (1) | ZA838591B (xx) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL67623A (en) * | 1983-01-05 | 1984-09-30 | Teva Pharma | 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it |
US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
DK8502611A (xx) * | 1985-08-08 | 1986-12-12 | ||
ES8605220A1 (es) * | 1985-10-25 | 1986-03-16 | Espanola Prod Quimicos | Procedimiento de preparacion de esteres del dietilenglicol |
US4912248A (en) * | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
JPH06501448A (ja) * | 1989-12-26 | 1994-02-17 | ノバ ファーマシューティカル コーポレイション | 無水物プロドラッグ組成物 |
GB9001405D0 (en) * | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
EP0577725A4 (en) * | 1991-03-29 | 1996-04-17 | Univ Florida | Targeted drug delivery via mixed phosphate derivatives |
JPH06509099A (ja) * | 1991-07-03 | 1994-10-13 | サノ・コーポレーシヨン | ジクロフエナツクの経皮デリバリーに対する組成物及び方法 |
AU674330B2 (en) * | 1992-06-30 | 1996-12-19 | Howard K. Shapiro | Composition containing amine and amine-related derivatives of benzoic acid and uses therefor including treating inflammatory diseases |
IT1274175B (it) * | 1994-11-22 | 1997-07-15 | Lab Alchemia Srl | Procedimento per la preparazione di una combinazione chimica farmacologicamente attiva |
USRE40546E1 (en) * | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
ES2225879T3 (es) * | 1995-05-01 | 2005-03-16 | Scarista Limited | Esteres de acido nicotinico y composiciones farmaceuticas que los contienen. |
US7109326B2 (en) * | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
US6762182B1 (en) | 1999-01-07 | 2004-07-13 | Vanderbilt University | Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors |
US6207700B1 (en) | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
TWI262791B (en) * | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6927239B1 (en) * | 2000-08-02 | 2005-08-09 | Pharmanutrients | Methods and compositions for the attenuation and/or prevention of stress/catabolic responses |
US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
US20030060465A1 (en) * | 2000-12-19 | 2003-03-27 | Jilani Jamal A. | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds |
PL348487A1 (en) * | 2001-07-06 | 2003-01-13 | Pan | New esters of the acetylisalicylic acid with oligomers of the 3-hydrobutyric acid, method of their manufacture and preparations containing these esters |
WO2005002293A2 (en) * | 2003-06-25 | 2005-01-06 | Vanderbilt University | Cox-2-targeted imaging agents |
JP2007534702A (ja) * | 2004-04-26 | 2007-11-29 | バンダービルト・ユニバーシティ | 胃腸毒性の低い治療薬としてのインドール酢酸、及びインデン酢酸誘導体 |
US20070053984A1 (en) * | 2005-03-03 | 2007-03-08 | Monique Spann-Wade | Topical gels compositions |
JP4938771B2 (ja) | 2005-06-20 | 2012-05-23 | ゼノポート,インコーポレーテッド | トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用 |
CN101528222A (zh) | 2006-06-19 | 2009-09-09 | 范德比尔特大学 | 用于诊断性和治疗性靶向cox-2的方法和组合物 |
US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
CA2740087C (en) | 2008-10-08 | 2019-07-23 | Kyphia Pharmaceuticals, Inc. | Gaba conjugates and methods of use thereof |
WO2010056919A2 (en) * | 2008-11-12 | 2010-05-20 | Kyphia Pharmaceuticals, Inc. | Eflornithine prodrugs, conjugates and salts, and methods of use thereof |
US20110060040A1 (en) * | 2009-09-04 | 2011-03-10 | Xenoport, Inc. | Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid |
US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
US20230000812A1 (en) * | 2020-08-13 | 2023-01-05 | Nanjing Heron Pharmaceutical Science And Technology Co., Ltd. | Ibuprofen ester prodrug, pharmaceutical composition, preparation method and application |
US20230126556A1 (en) * | 2021-06-29 | 2023-04-27 | Nanjing Heron Pharmaceutical Science And Technology Co., Ltd. | Ibuprofen ester derivative and emulsion preparation thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3412131A (en) * | 1966-08-02 | 1968-11-19 | Smith Kline French Lab | Alkyl carbonates of salicylic acid |
US3646201A (en) * | 1969-07-31 | 1972-02-29 | Liggett & Myers Inc | Salicylate carbonate compounds |
US3873521A (en) * | 1970-09-17 | 1975-03-25 | Astra Laekemedel Ab | Esters of {60 -amino penicillins |
JPS5562049A (en) * | 1978-10-31 | 1980-05-10 | Bago Sa Labor | Novel ester of phenyll and pyridinee33carboxylic acid and its manufacture |
US4412994A (en) * | 1980-04-24 | 1983-11-01 | Interx Research Corporation | Mannich-base hydroxamic acid prodrugs, compositions and use |
EP0079872B1 (en) * | 1981-11-17 | 1985-03-20 | KabiVitrum AB | Antifibrinolytically active compounds |
US4542158A (en) * | 1981-12-21 | 1985-09-17 | Merck & Co., Inc. | Prodrug esters of diflunisal and related compounds |
CA1191153A (en) * | 1981-12-21 | 1985-07-30 | Conrad P. Dorn | Forms of diflunisal and related compounds |
US4426391A (en) * | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
-
1982
- 1982-12-09 IL IL67445A patent/IL67445A/xx unknown
-
1983
- 1983-11-08 AU AU21056/83A patent/AU563459B2/en not_active Ceased
- 1983-11-17 ZA ZA838591A patent/ZA838591B/xx unknown
- 1983-12-08 DE DE8383307490T patent/DE3369972D1/de not_active Expired
- 1983-12-08 AT AT83307490T patent/ATE25665T1/de not_active IP Right Cessation
- 1983-12-08 JP JP58230741A patent/JPS59112944A/ja active Pending
- 1983-12-08 EP EP83307490A patent/EP0112130B1/en not_active Expired
-
1986
- 1986-02-12 US US06/810,393 patent/US4851426A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2105683A (en) | 1984-06-14 |
ATE25665T1 (de) | 1987-03-15 |
DE3369972D1 (en) | 1987-04-09 |
JPS59112944A (ja) | 1984-06-29 |
AU563459B2 (en) | 1987-07-09 |
EP0112130A1 (en) | 1984-06-27 |
IL67445A0 (en) | 1983-05-15 |
US4851426A (en) | 1989-07-25 |
EP0112130B1 (en) | 1987-03-04 |
ZA838591B (en) | 1984-07-25 |
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