IL66580A - 1,5-diphenyl-2-piperazinylalkyl-pyrazolin-3-one compounds,their preparation and pharmaceutical compositions containing them - Google Patents
1,5-diphenyl-2-piperazinylalkyl-pyrazolin-3-one compounds,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL66580A IL66580A IL66580A IL6658082A IL66580A IL 66580 A IL66580 A IL 66580A IL 66580 A IL66580 A IL 66580A IL 6658082 A IL6658082 A IL 6658082A IL 66580 A IL66580 A IL 66580A
- Authority
- IL
- Israel
- Prior art keywords
- halogen atom
- group
- hydrogen
- carbon atoms
- lower alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 methylenedioxy Chemical group 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813132915 DE3132915A1 (de) | 1981-08-20 | 1981-08-20 | 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL66580A0 IL66580A0 (en) | 1982-12-31 |
| IL66580A true IL66580A (en) | 1985-10-31 |
Family
ID=6139713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL66580A IL66580A (en) | 1981-08-20 | 1982-08-19 | 1,5-diphenyl-2-piperazinylalkyl-pyrazolin-3-one compounds,their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4442102A (en, 2012) |
| EP (1) | EP0072960B1 (en, 2012) |
| JP (1) | JPS5839668A (en, 2012) |
| AT (1) | ATE43841T1 (en, 2012) |
| AU (1) | AU555215B2 (en, 2012) |
| CA (1) | CA1208643A (en, 2012) |
| DD (1) | DD202563A5 (en, 2012) |
| DE (2) | DE3132915A1 (en, 2012) |
| DK (1) | DK149947C (en, 2012) |
| ES (1) | ES8306143A1 (en, 2012) |
| FI (1) | FI73673C (en, 2012) |
| GR (2) | GR78228B (en, 2012) |
| HU (1) | HU187572B (en, 2012) |
| IE (1) | IE55377B1 (en, 2012) |
| IL (1) | IL66580A (en, 2012) |
| NO (1) | NO158185C (en, 2012) |
| NZ (1) | NZ201643A (en, 2012) |
| PH (1) | PH19107A (en, 2012) |
| PT (1) | PT75353B (en, 2012) |
| ZA (1) | ZA825381B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3442860A1 (de) * | 1984-11-24 | 1986-05-28 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| PT1309591E (pt) * | 2000-08-14 | 2007-04-30 | Ortho Mcneil Pharm Inc | Pirazoles substituídos |
| WO2003105853A1 (en) | 2002-06-12 | 2003-12-24 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| WO2011051958A1 (en) * | 2009-10-30 | 2011-05-05 | E.I. Du Pont De Nemours And Company | Fungicidal pyrazolones |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE66610C (de) * | FARBWERKE VORM. MEISTER LUCIUS & BRÜNING in Höchst a. M | Verfahren zur Darstellung von Oxaethylmethylphenylpyrazolon | ||
| DE74912C (en, 2012) * | ||||
| GB666578A (en) * | 1948-01-10 | 1952-02-13 | Luxema | Process for the preparation of derivatives of 1, 2, 3 substituted pyrazolones and derivatives obtained by this process |
| US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
| DE2824764A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung |
| DE2828529A1 (de) * | 1978-06-29 | 1980-01-17 | Kali Chemie Pharma Gmbh | Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel |
-
1981
- 1981-08-20 DE DE19813132915 patent/DE3132915A1/de not_active Withdrawn
-
1982
- 1982-07-27 ZA ZA825381A patent/ZA825381B/xx unknown
- 1982-07-30 PT PT75353A patent/PT75353B/pt not_active IP Right Cessation
- 1982-08-09 EP EP82107193A patent/EP0072960B1/de not_active Expired
- 1982-08-09 AT AT82107193T patent/ATE43841T1/de not_active IP Right Cessation
- 1982-08-09 DE DE8282107193T patent/DE3279756D1/de not_active Expired
- 1982-08-10 CA CA000409072A patent/CA1208643A/en not_active Expired
- 1982-08-17 DD DD82242578A patent/DD202563A5/de unknown
- 1982-08-18 GR GR69059A patent/GR78228B/el unknown
- 1982-08-18 PH PH27741A patent/PH19107A/en unknown
- 1982-08-18 GR GR69057A patent/GR76272B/el unknown
- 1982-08-18 HU HU822675A patent/HU187572B/hu not_active IP Right Cessation
- 1982-08-19 US US06/409,631 patent/US4442102A/en not_active Expired - Fee Related
- 1982-08-19 IL IL66580A patent/IL66580A/xx unknown
- 1982-08-19 ES ES515107A patent/ES8306143A1/es not_active Expired
- 1982-08-19 NZ NZ201643A patent/NZ201643A/xx unknown
- 1982-08-19 AU AU87424/82A patent/AU555215B2/en not_active Ceased
- 1982-08-19 IE IE2002/82A patent/IE55377B1/en unknown
- 1982-08-19 DK DK372382A patent/DK149947C/da not_active IP Right Cessation
- 1982-08-19 NO NO822827A patent/NO158185C/no unknown
- 1982-08-19 FI FI822883A patent/FI73673C/fi not_active IP Right Cessation
- 1982-08-20 JP JP57143479A patent/JPS5839668A/ja active Granted
-
1983
- 1983-12-22 US US06/564,399 patent/US4515944A/en not_active Expired - Fee Related
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