IL58038A0 - Pyrazine derivatives their production and pharmaceutical compositions containing them - Google Patents

Pyrazine derivatives their production and pharmaceutical compositions containing them

Info

Publication number
IL58038A0
IL58038A0 IL58038A IL5803879A IL58038A0 IL 58038 A0 IL58038 A0 IL 58038A0 IL 58038 A IL58038 A IL 58038A IL 5803879 A IL5803879 A IL 5803879A IL 58038 A0 IL58038 A0 IL 58038A0
Authority
IL
Israel
Prior art keywords
production
pharmaceutical compositions
compositions containing
pyrazine derivatives
pyrazine
Prior art date
Application number
IL58038A
Other languages
English (en)
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of IL58038A0 publication Critical patent/IL58038A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL58038A 1978-08-15 1979-08-13 Pyrazine derivatives their production and pharmaceutical compositions containing them IL58038A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7833431 1978-08-15
GB7848348 1978-12-13

Publications (1)

Publication Number Publication Date
IL58038A0 true IL58038A0 (en) 1979-12-30

Family

ID=26268543

Family Applications (1)

Application Number Title Priority Date Filing Date
IL58038A IL58038A0 (en) 1978-08-15 1979-08-13 Pyrazine derivatives their production and pharmaceutical compositions containing them

Country Status (9)

Country Link
US (1) US4296114A (de)
EP (1) EP0008864A1 (de)
AU (1) AU4985379A (de)
DK (1) DK338379A (de)
FI (1) FI792507A (de)
GR (1) GR69706B (de)
IL (1) IL58038A0 (de)
NO (1) NO792653L (de)
PT (1) PT70064A (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030795A3 (de) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Chinoxalinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Zusammensetzungen und Benzenderivate
DE3032994A1 (de) * 1980-09-02 1982-04-22 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyrazino-azepine, deren herstellung und diese sie enthaltende arzneimittel
JPS62198671A (ja) * 1986-02-25 1987-09-02 Toyo Jozo Co Ltd １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体
JPS62281878A (ja) * 1986-02-26 1987-12-07 Taisho Pharmaceut Co Ltd アザアントラセン化合物
JPH0678319B2 (ja) * 1986-03-11 1994-10-05 東ソー株式会社 キノキサリノン誘導体
JPS6450868A (en) * 1987-08-21 1989-02-27 Toyo Jozo Kk 1-substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivative
JPH0276860A (ja) * 1987-10-05 1990-03-16 Toyo Jozo Co Ltd ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
GB9413975D0 (en) 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
FR2696456B1 (fr) * 1992-10-07 1995-01-06 Pf Medicament Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique.
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
WO1995018616A2 (en) * 1994-01-03 1995-07-13 Acea Pharm Inc 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor
GB2291422A (en) * 1994-07-18 1996-01-24 Fujisawa Pharmaceutical Co 4-phenyl-pyrido[2,3-b]pyrazin-4-ones
FR2731221B1 (fr) * 1995-03-01 1997-05-30 Pf Medicament Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
EP1380298A3 (de) * 1996-05-23 2004-04-07 Bristol-Myers Squibb Pharma Company Tetrahydropteridines und Pyridylpiperazine zur Behandlung von neurologischen Krankheiten, Anorexia, Entzündungen
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
US5869487A (en) * 1996-10-24 1999-02-09 Merck & Co., Inc. Pyrido 3,4-B!pyrazines for use as thrombin inhibitors
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
CN1328555A (zh) * 1998-09-29 2001-12-26 藤泽药品工业株式会社 吡啶并吡嗪化合物的新的盐及其结晶
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
JP2003501389A (ja) 1999-06-04 2003-01-14 メルク エンド カムパニー インコーポレーテッド トロンビン阻害物質
EE200300546A (et) * 2001-05-14 2004-04-15 Bristol-Myers Squibb Pharma Company Asendatud pürasinoonid, püridiinid ja pürimidiinid kui kortikotropiini vabastava faktori ligandid
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
CN1886389B (zh) * 2003-09-30 2010-07-21 詹森药业有限公司 喹喔啉化合物
WO2005042501A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
CN1901917A (zh) * 2004-01-06 2007-01-24 詹森药业有限公司 作为糖原磷酸化酶抑制剂用于治疗糖尿病和肥胖症的(3－氧代－3，4－二氢－喹喔啉－2－基－氨基)－苯甲酰胺衍生物和相关化合物
JP2008509212A (ja) * 2004-08-09 2008-03-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 中枢神経系障害の治療のための新規なキノキサリノンノルエピネフリン再吸収阻害剤
US7601716B2 (en) * 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
DE102007050673A1 (de) 2007-10-19 2009-04-23 Friedrich-Schiller-Universität Jena Neue Hexaaza-acene und Verfahren zu ihrer Herstellung
MX2010004673A (es) 2007-11-06 2010-05-27 Astrazeneca Ab Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos.
BRPI0908569B8 (pt) 2008-03-05 2021-05-25 Merck Patent Gmbh estimuladores de secreção de insulina derivados de piridopirazinonas, seu uso, e composição farmacêutica
EA021325B1 (ru) * 2008-03-05 2015-05-29 Мерк Патент Гмбх Производные пиразинона как стимуляторы секреции инсулина, способы их получения и их применение для лечения диабетов
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
KR101738491B1 (ko) 2009-06-26 2017-05-22 이하라케미칼 고교가부시키가이샤 케토말론산 화합물 또는 그 수화물의 제조방법
WO2011039528A1 (en) 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
JP5921500B2 (ja) 2013-07-19 2016-05-24 イハラケミカル工業株式会社 ケトマロン酸化合物の製造方法
AU2015216279B2 (en) 2014-02-17 2018-01-18 Kumiai Chemical Industry, Co., Ltd. Method for continuously producing ketomalonic acid compound using flow reactor
EP3394046B1 (de) * 2015-12-24 2022-03-09 The Regents Of The University Of California Cftr-regulatoren und verfahren zur verwendung davon
EP3672598A4 (de) 2017-08-24 2021-04-28 The Regents of The University of California Arzneimittelzusammensetzungen für das auge

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189552B (de) * 1959-07-03 1965-03-25 Donau Pharmazie Ges M B H Verfahren zur Herstellung von 2-Oxo-1, 2-dihydrochinoxalinen und von deren Salzen und quaternaeren Ammoniumverbindungen
US4077955A (en) * 1977-02-17 1978-03-07 E. R. Squibb & Sons, Inc. Amino derivatives of 1,2,3,4-tetrahydro-2-oxopyrido[2,2-b]-pyrazine carboxylic acids and esters

Also Published As

Publication number Publication date
EP0008864A1 (de) 1980-03-19
NO792653L (no) 1980-02-18
PT70064A (en) 1979-09-01
FI792507A (fi) 1980-02-16
DK338379A (da) 1980-02-16
US4296114A (en) 1981-10-20
GR69706B (de) 1982-07-09
AU4985379A (en) 1980-02-21

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